Hostname: page-component-6766d58669-r8qmj Total loading time: 0 Render date: 2026-05-20T01:45:28.727Z Has data issue: false hasContentIssue false
  • English
  • Français

Sudden sensorineural hearing loss in a patient with primary antiphospholipid syndrome

Published online by Cambridge University Press:  10 April 2007

K-T Kang  and
Y-H Young
K-T Kang
Affiliation:
Department of Otolaryngology, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan
Y-H Young*
Affiliation:
Department of Otolaryngology, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan
*
Address for correspondence: Dr Yi-Ho Young, Department of Otolaryngology, National Taiwan University Hospital, 1 Chang-Te St, Taipei, Taiwan. Fax: +886 2 23946674 E-mail: youngyh@ha.mc.ntu.edu.tw
Get access Rights & Permissions [Opens in a new window]

Abstract

Objective:

Despite multiple systemic manifestations, sudden sensorineural hearing loss in a patient with antiphospholipid syndrome is rarely reported.

Patient:

A 46-year-old man with primary antiphospholipid syndrome had a sudden onset of hearing loss and tinnitus in the right ear in December 2005, because he discontinued use of warfarin and acetylsalicylic acid for a few days.

Results:

Audiometry revealed saucer-type sensorineural hearing loss with a pure tone average of 73 dB in the right ear, and flat-type hearing loss with a pure tone average of 25 dB in the left ear. Electronystagmography displayed multiple central signs and bilateral canal paresis, while a vestibular evoked myogenic potential test revealed bilateral delayed responses. After admission, the patient was re-treated with warfarin and acetylsalicylic acid. Follow-up audiometry showed recovery of right-sided hearing, with a pure tone average of 12 dB, three days after presentation.

Conclusion:

Consensus exists on the effectiveness of anticoagulant agents in aiding a favourable outcome of sudden sensorineural hearing loss in patients with antiphospholipid syndrome.

Keywords

Antiphospholipid SyndromeSensorineural DeafnessWarfarin

Information

Type
Clinical Records
Information
The Journal of Laryngology & Otology , Volume 122 , Issue 2 , February 2008 , pp. 204 - 206
Copyright
Copyright © JLO (1984) Limited 2007

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

Article purchase

Temporarily unavailable

References

1 Toubi, E, Ben-David, J, Kessel, A, Halas, K, Sabo, E, Luntz, M. Immune-mediated disorders associated with idiopathic sudden sensorineural hearing loss. Ann Otol Rhinol Laryngol 2004;113:445–9CrossRefGoogle ScholarPubMed
2 Khamashta, MA, Bertolaccini, ML, Hughes, GRV. Antiphospholipid (Hughes) syndrome. Autoimmunity 2004;37:309–12CrossRefGoogle ScholarPubMed
3 Sammaritano, LR. Antiphospholipid syndrome: review. South Med J 2005;98:617–25Google Scholar
4 Behbehani, R, Sergott, RC, Savino, PJ. The antiphospholipid antibody syndrome: diagnostic aspects. Curr Opin Ophthalmol 2004;15:483–5CrossRefGoogle ScholarPubMed
5 Wong, M, Sangle, S, Jan, W, Hughes, GR, D'Cruz, DP. Intracerebral arterial stenosis with neurological events associated with antiphospholipid syndrome. Rheumatol 2005;44:948–9Google Scholar
6 Marai, I, Zandman-Goddard, G, Shoenfeld, Y. The systemic nature of the antiphospholipid syndrome. Scand J Rheumatol 2004;33:365–72CrossRefGoogle ScholarPubMed
7 Compadretti, GC, Brandolini, C, Tasca, I. Sudden sensorineural hearing loss in lupus erythematosus associated with antiphospholipid syndrome: case report and review. Ann Otol Rhinol Laryngol 2005;114:214–18Google Scholar
8 Bir, LS, Esmeli, FO, Ardic, FN. Sudden sensorineural hearing loss in a patient with primary antiphospholipid syndrome. J Thromb Thrombolysis 2006;21:277Google Scholar
9 de Groot, PG, Derksen, RHMW. The antiphospholipid syndrome: clinical characteristics, laboratory features and pathogenesis. Curr Opin Infect Dis 2005;18:205–10CrossRefGoogle ScholarPubMed
10 Noguchi, Y, Komatsuzaki, A, Nishida, H. Electrocochleographic study in patients with vestibular schwannomas and U-shaped audiograms. Audiology 2000;39:19–23Google Scholar
11 Chen, CH, Young, Y-H. Vestibular evoked myogenic potentials in brainstem stroke. Laryngoscope 2003;113:990–3CrossRefGoogle ScholarPubMed
12 Galli, M, Barbui, T. Antiphospholipid syndrome: definition and treatment. Semin Thromb Hemost 2003;29:195–204CrossRefGoogle ScholarPubMed
13 Green, L, Miller, EB. Sudden sensorineural hearing loss as a first manifestation of systemic lupus erythematosus: association with anticardiolipin antibodies. Clin Rheumatol 2001;20:220–2CrossRefGoogle ScholarPubMed
14 Wilson, A, Gharavi, AE, Koike, T, Lockshin, MD, Branch, DW, Piette, JC et al. International consensus statement on preliminary classification criteria for definite antiphospholipid syndrome. Arthritis Rheum 1999;42:1309–11Google Scholar
15 Mouadeb, DA, Ruckenstein, MJ. Antiphospholipid inner ear syndrome. Laryngoscope 2005;115:879–83CrossRefGoogle ScholarPubMed
16 Bachor, E, Kremmer, S, Kreuzfelder, E, Jahnke, K, Seidahmadi, S. Antiphospholipid antibodies in patients with sensorineural hearing loss. Eur Arch Otorhinolaryngol 2005;262:622–6CrossRefGoogle ScholarPubMed
17 Digiovanni, JJ, Nair, P. Spontaneous recovery of sudden sensorineural hearing loss: possible association with autoimmune disorder. J Am Acad Audiol 2006;17:498–505Google Scholar