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TB and vitamin D

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Nnoaham KE. et al. Low serum vitamin D levels and tuberculosis: a systematic review and meta-analysis. Int J Epidemiol. 2008 Feb;37(1):113–9.

Wejse C. et al. Vitamin D as supplementary treatment for tuberculosis: a double-blind, randomized, placebo-controlled trial. Am J Respir Crit Care Med. 2009 May 1;179(9):843–50.

Martineau AR. et al. A single dose of vitamin D enhances immunity to mycobacteria. Am J Respir Crit Care Med. 2007 Jul 15;176(2):208–13.

Published online by Cambridge University Press:  11 September 2013

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In a nutshell

Vitamin D levels are lower in TB, and linked with resistance to and recovery from the clinical disease. This is most likely related to the vitamin's immunological functions.

Vitamin D has been used as part of clinical treatment for TB for over 50 years, but the few good quality RCTs do not collectively provide any clear answer on whether it is effective in this role.

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Type
Brief Report
Copyright
Copyright © Cambridge University Press 2009

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