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TP53 mutation may underlie increasing incidence of external auditory canal carcinoma
Published online by Cambridge University Press: 11 November 2024
Abstract
Background
Primary neoplasm of the external auditory canal has historically been documented to have a low incidence rate of between one and six per million internationally, with UK incidence yet to be officially cited.
Methods
Here, we report a rise in incidence at a single UK trust with seven carcinomas (six T4 external auditory canal squamous cell and one T4 basal cell) reported within an 18-month period. All tumours underwent next generation sequencing.
Results
The cases recorded represented a twofold rise in incidence in reference to international literature from a population-adjusted estimate of 0.5–3 cases for the catchment area to seven cases. All cases were treated with temporal bone resections (n = 7) and with post-operative radiotherapy in six cases. Tumour analysis showed all were TP53 mutant and human papilloma virus (HPV)/P16 negative.
Conclusion
We suggest chronic inflammation and genetic alterations as putative contributory factors in our case series and outline clinical strategies for timely detection of external auditory canal neoplasms.
Information
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- Copyright
- © The Author(s), 2024. Published by Cambridge University Press on behalf of J.L.O. (1984) LIMITED.
Footnotes
Aashish Pandya takes responsibility for the integrity of the content of the paper
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