Hostname: page-component-8448b6f56d-mp689 Total loading time: 0 Render date: 2024-04-23T18:23:30.089Z Has data issue: false hasContentIssue false
  • English
  • Français

Benzodiazepines in the treatment of tinnitus

Published online by Cambridge University Press:  27 May 2011

Richard Lechtenberg  and
Abraham Shulman
Richard Lechtenberg
Affiliation:
(New York)
Abraham Shulman
Affiliation:
(New York)
Get access Rights & Permissions [Opens in a new window]

Abstract

A randomized controlled study using benzodiazepines to treat patients with chronic subjective tinnitus was performed to determine if these drugs could suppress intractable tinnitus. Trials with the antihistames meclizine, chlorpheniramine, and dexchlorpheniramine were used as the controls in the evaluation of diazepam, flurazepam, carbamazepine, oxazepam, and clonazepam. Of all the benzodiazepines studied, only oxazepam and clonazepam were significantly more effective than antihistamines in suppressing chronic tinnitus, but these two drugs alleviated the symptom in 52 per cent and 69 per cent of the individuals treated respectively. Oxazepam 30 milligrams daily or clonazepam 0.5 milligrams three times daily provides substantial control of chronic tinnitus.

Type
Session V. Treatment Methods and Results (Chairman: A. Shulman)
Information
The Journal of Laryngology & Otology , Volume 98 , supplement S9: Proceedings of the II International Tinnitus Seminar. New York, 10 and 11 June 1983 , June 1984 , pp. 271 - 276
Copyright
Copyright © JLO (1984) Limited 1984

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

1.Cathcart, J-M. (1982) Assessment of the value of tocainide hydrochloride in the treatment of tinnitus. Journal of Laryngology and Otology, 96: 981–984.CrossRefGoogle ScholarPubMed
2.Douek, E. (1981) Classification of tinnitus. In Tinnitus (Ciba Foundation Symposium 85). London, Pitman Books Ltd, pp. 4–15.Google ScholarPubMed
3.Goldstein, A. (1964) Biostatistics. New York, Macmillan Publishing Co., p. 272.Google Scholar
4.Goodey, R. J. (1981) Drugs in the treatment of tinnitus. In Tinnitus (Ciba Foundation Symposium 85). London, Pitman Books Ltd., pp. 263–278.Google ScholarPubMed
5.Goodhill, V. (1981) Panel on tinnitus control: Comment. Annals of Otology, Rhinology and Laryngology, 90: 607–609.CrossRefGoogle Scholar
6.House, J. W. (1981) Management of the tinnitus patient. Annals of Otology, Rhinology and Laryngology, 90:597–601.CrossRefGoogle ScholarPubMed
7.Israel, J. M., Connelly, J. S., McTigue, S. T.et at. (1982) Lidocaine in the treatment of tinnitus aurium. Archives of Otolaryngology, 108: 471–473.CrossRefGoogle ScholarPubMed
8.Ouaknine, G. E., Robert, R., Molina-Negro, P. and Hardy, J. (1980) Geniculate neuralgia and audio-vestibular disturbances due to compression of the intermediate and eighth nerves by the postero-inferior cerebellar artery. Surgical Neurology, 13: 147–150.Google ScholarPubMed
9.Schleuning, A. (1981) Neurotologic evaluation of subjective idiopathic tinnitus. Journal of Laryngology and Otology, Supplement 4: 99–101.Google Scholar
10.Shea, J. J., Emmett, J. R., Orchik, D. J. et al. (1981) Medical treatment of tinnitus. Annals of Otology, Rhinology and Laryngology, 90: 601–606.CrossRefGoogle ScholarPubMed
11.Shulman, A. (1981) Vasodilator-Antihistamine Therapy and Tinnitus Control. Transactions of First International Tinnitus Seminar. Journal of Laryngology and Otology, Supplement 4: 123–129.Google Scholar
12.Shulman, A. (1981) Acoustic tumor and tinnitus. Transactions of First International Tinnitus Seminar. Journal of Laryngology and Otology, Supplement 4: 143–148.Google Scholar
13.Shulman, A. andSeitz, M. R. (1981) Central tinnitus—Diagnosis and treatment. Observations simultaneous binaural auditory brain responses with monaural stimulation in the tinnitus patient. Laryngoscope, 91: 2025–2035.CrossRefGoogle ScholarPubMed