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Syphilis resembling human papilloma virus associated oropharyngeal cancer: case report and literature review of recent incidence trends

Published online by Cambridge University Press:  12 January 2022

D Maki Open the ORCID record for D Maki [Opens in a new window] ,
K Ebisumoto ,
A Sakai  and
K Okami
D Maki*
Affiliation:
Department of Otolaryngology – Head and Neck Surgery, Tokai University School of Medicine, Isehara, Japan
K Ebisumoto
Affiliation:
Department of Otolaryngology – Head and Neck Surgery, Tokai University School of Medicine, Isehara, Japan
A Sakai
Affiliation:
Department of Otolaryngology – Head and Neck Surgery, Tokai University School of Medicine, Isehara, Japan
K Okami
Affiliation:
Department of Otolaryngology – Head and Neck Surgery, Tokai University School of Medicine, Isehara, Japan
*
Author for correspondence: Dr Daisuke Maki, Department of Otolaryngology – Head and Neck Surgery, Tokai University School of Medicine, 143 Shimokasuya, Isehara, Kanagawa 259-1193, Japan E-mail: d.maki@tokai.ac.jp Fax: +81 463 941 611
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Abstract

Background

The yearly incidence of syphilis has risen markedly in Japan and worldwide. There has also been an increased incidence of human papilloma virus associated oropharyngeal cancer, which presents with clinical features similar to those of syphilis.

Objective

A case of syphilis with clinical manifestation resembling that of human papilloma virus associated oropharyngeal cancer is reported, along with a literature review of similar cases.

Methods

Clinical case reports and review of previous literature.

Conclusion

Syphilis may cause irregular mucosal lesions of the oropharynx and cystic lymphadenopathy. It is difficult to diagnose syphilis only by examining pathological specimens, without clinical information such as Treponema pallidum antibody findings. It is necessary to correctly understand the characteristics of syphilis and human papilloma virus associated oropharyngeal cancer to ensure prompt diagnosis and treatment.

Keywords

SyphilisHuman Papilloma VirusOropharyngeal CancerLymphadenopathyCystic Changes

Information

Type
Main Article
Information
The Journal of Laryngology & Otology , Volume 137 , Issue 2 , February 2023 , pp. 200 - 204
Copyright
Copyright © The Author(s), 2022. Published by Cambridge University Press on behalf of J.L.O. (1984) LIMITED

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Footnotes

Dr D Maki takes responsibility for the integrity of the content of the paper

References

Cerchione, C, Maraolo, AE, Marano, L, Pugliese, N, Nappi, D, Tosone, G et al. Secondary syphilis mimicking malignancy: a case report and review of literature. J Infect Chemother 2017;23:576–8CrossRefGoogle ScholarPubMed
Ministry of Health, Labour and Welfare. Number of reported sexually transmitted diseases. In: https://www.mhlw.go.jp/topics/2005/04/tp0411-1.html [26 August 2019]Google Scholar
Chaturvedi, AK, Engels, EA, Pfeiffer, RM, Hernandez, BY, Xiao, W, Kim, E et al. Human papillomavirus and rising oropharyngeal cancer incidence in the United States. J Clin Oncol 2011;29:4294–301CrossRefGoogle ScholarPubMed
Näsman, A, Attner, P, Hammarstedt, L, Du, J, Eriksson, M, Giraud, G et al. Incidence of human papillomavirus (HPV) positive tonsillar carcinoma in Stockholm, Sweden; an epidemic of viral-induced carcinoma? Int J Cancer 2009;125:362–6CrossRefGoogle ScholarPubMed
Hama, T, Tokumaru, Y, Fujii, M, Yane, K, Okami, K, Kato, K et al. Prevalence of human papillomavirus in oropharyngeal cancer: a multicenter study in Japan. Oncology 2014;87:173–82CrossRefGoogle ScholarPubMed
Hamlyn, E, Marriott, D, Gallagher, RM. Secondary syphilis presenting as tonsillitis in three patients. J Laryngol Otol 2006;120:602–4CrossRefGoogle ScholarPubMed
Ikenberg, K, Springer, E, Bräuninger, W, Kerl, K, Mihic, D, Schmid, S et al. Oropharyngeal lesions and cervical lymphadenopathy: syphilis is a differential diagnosis that is still relevant. J Clin Pathol 2010;63:731–6CrossRefGoogle ScholarPubMed
Tamura, S, Takimoto, Y, Hoshida, Y, Okada, K, Yoshimura, M, Uji, K et al. A case of primary oropharyngeal and gastric syphilis mimicking oropharyngeal cancer. Endoscopy 2008;40(suppl 2):E235–6CrossRefGoogle ScholarPubMed
Jategaonkar, A, Klimczak, J, Agarwal, J, Badhey, A, Portnoy, WM, Damiano, A et al. Syphilis of the oropharynx: case series of “The Great Masquerader”. Am J Otolaryngol 2019;40:143–6CrossRefGoogle Scholar
Oddo, D, Carrasco, G, Capdeville, F, Ayala, MF. Syphilitic tonsillitis presenting as an ulcerated tonsillar tumor with ipsilateral lymphadenopathy. Ann Diagn Pathol 2007;11:353–7CrossRefGoogle ScholarPubMed
Sato, J, Tsubota, H, Himi, T. Syphilitic cervical lymphadenopathy. Eur Arch Otorhinolaryngol 2003;260:283–5CrossRefGoogle ScholarPubMed
Ripoll, E, Montironi, C, Alos, L, Pujol, T, Berenguer, J, Oleaga, L. Oropharyngeal syphilis: imaging and pathologic findings in two patients. Head Neck Pathol 2017;11:399–403CrossRefGoogle ScholarPubMed
Ebisumoto, K, Okami, K, Sakai, A, Sugimoto, R, Iida, M. Successful detection of a minute tonsillar cancer lesion on transoral examination with narrow band imaging: a report of 2 cases. Head Neck 2016;38:E2421–4CrossRefGoogle ScholarPubMed
Goldenberg, D, Begum, S, Westra, WH, Khan, Z, Sciubba, J, Pai, SA et al. Cystic lymph node metastasis in patients with head and neck cancer: an HPV-associated phenomenon. Head Neck 2008;30:898–903CrossRefGoogle ScholarPubMed
Komeno, Y, Ota, Y, Koibuchi, T, Imai, Y, Iihara, K, Ryu, T. Secondary syphilis with tonsillar and cervical lymphadenopathy and a pulmonary lesion mimicking malignant lymphoma. Am J Case Rep 2018;19:238–43CrossRefGoogle Scholar