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Does severe water deprivation affect the inner ear?

An experimental study of the gerbilline endolyphatic sac

Published online by Cambridge University Press:  29 June 2007

M. Barbara ,
D. Bagger-Sjöbäck ,
H. Rask-Andersen  and
R. Filipo
M. Barbara*
Affiliation:
Department of Otolaryngology, University ‘La Sapienza’, Rome, Italy
D. Bagger-Sjöbäck
Affiliation:
Department of Otolaryngology, Karolinska Hospital, Stockhom, Sweden
H. Rask-Andersen
Affiliation:
Department of Otolaryngology, Akademiska Hospital, Uppsala, Sweden.
R. Filipo
Affiliation:
Department of Otolaryngology, University ‘La Sapienza’, Rome, Italy
*
Dr. Maurizio Barbara, Department of Otolaryngology, University “La Sapienza”, 00185 Rome, Italy.
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Abstract

Through an ultrastructural study of the endolymphatic duct (ED) and sac (ES) system, the effects of an impaired body fluid metabolism on the inner ear fluid environment in the mongolian gerbil has been evaluated. A dehydrative state has been determined depriving of water for both five and twelve days this desert animal, which is known to withstand long periods of water abstinence. The morphological changes of the ED and ES under these circumstances have been compared with those induced by ethacrynic acid intoxication. Although the cochlear partition did not show signs of damage, the ED and ES system seems to be negatively influenced by the dehydrative state and displays a marked imbibition of the subepithelial tissue, which at places shows accumulation of an organic matrix.

A regulating role for the antidiuretic hormone on the inner ear fluids of the mongolian gerbil is also proposed and discussed.

Information

Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 103 , Issue 1 , January 1989 , pp. 22 - 29
Copyright
Copyright © JLO (1984) Limited 1989

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References

Angelborg, C., Klockhoff, I. and Stahle, J. (1973) Serum osmolality in patients with Meniere's disease. Acta Otolaryngologica, 76: 450–454.CrossRefGoogle ScholarPubMed
Baddouri, K., Buten, D., Imbert-Teboul, M., Le Bouffant, F., Marchetti, J., Chabardes, D. and Morel, F. (1984) Plasma antidiuretic hormone levels and kidney responsiveness to vaso pressin in the jerboa, Jaculus orientalis. General Comparative Endocrinology, 54: 203–215.CrossRefGoogle Scholar
Baddouri, K., El Hilali, M., Marchetti, J. and Menard, J. (1987) Renal excretion capacity in hydrated desert rodents (Jaculus orientalis and Jaculus deserti). Journal of Comparative Physiology B, 157: 237–240.CrossRefGoogle ScholarPubMed
Bagger-Sjöbäck, D. and Rask-Andersen, H. (1986) The permeability of the endolymphatic sac. A hypothesis of fluid and electrolyte exchange based on freeze fracturing. American Journal of Otology, 7: 134–140.Google ScholarPubMed
Bagger-Sjöbäck, D., Rask-Andersen, H. and Lundquist, P. G. (1980) Intercellular junctions in the epithelium of the endolymphatic sac. In Vosteen, K. H., Schuknecht, H. F., Pfaltz, C. R. et al. (eds.): Meniere's disease. Pathogenesis, diagnosis and treatment. Stuttgart, New York, George Thieme, 127–140.Google Scholar
Barbara, M., Rask-Andersen, H. and Bagger-Sjöbäck, D. (1987) Ultrastructure of the endolymphatic sac in the mongolian gerbil. Archives of Otorhinolaryngology, 244: 284–287.CrossRefGoogle ScholarPubMed
Barbara, M., Rask-Andersen, H. and Bagger-Sjöbäck, D. (1988a) Morphology of the endolymphatic duct and sac of the mongolian gerbil (Meriones unguiculatus). Acta Otolaryngologica, 105: 31–38.CrossRefGoogle Scholar
Barbara, M., Rask-Andersen, H. and Bagger-Sjöbäck, D. (1988b) The surface morphology of the endolymphatic sac of the mongolian gerbil (Meriones unguiculatus). Journal of Laryngology and Otology, 102: 308–313.CrossRefGoogle ScholarPubMed
Bosher, S. K., Smith, C. and Warren, R. L. (1973) The effect of ethacrynic acid on the cochlear endolymph and stria vascularis. Acta Otolaryngologica, 75: 184–191.CrossRefGoogle ScholarPubMed
Buchanan, J. G. and Stewart, A. D. (1974) Neurohypophysial store of vasopressin in the normal and the dehydrated gerbil (Meriones unguiculatus), with a note on kidney structure. Journal of Endocrinology, 60: 381–382.CrossRefGoogle ScholarPubMed
Donaldson, K. and Edwards, B. A. (1981) A comparison of the effects of saline imbibition and water deprivation on the composition of the blood, urine and pituitary neural lobe of the gerbil (Meriones unguiculatus). Comparative Biochemistry and Physiology, 68A: 31–35.CrossRefGoogle Scholar
Duvall, A. J., Santi, P. A. and Hukee, M. J. (1980) Cochlear fluid balance. A clinical/research overview. Annals of Otology, Rhinology and Laryngology, 89: 335–341.CrossRefGoogle ScholarPubMed
Erwall, C., Friberg, U., Bagger-Sjöbäck, D. and Rask-Andersen, H. (1988). Effects of ototoxic diuretics (Loop Diruetics) on the endolymphatic sac. ORL, 50: 42–53.CrossRefGoogle Scholar
Erwall, C., Friberg, U. and Rask-Andersen, H. (in press) General effects of hyperosmolar agents on the endolymphatic sac.Google Scholar
Friberg, U., Rask-Andersen, H. and Bagger-Sjöbäck, D. (1986) Human endolymphatic duct. An ultrastructural study. Archives of Otolaryngology, 110: 421–428.CrossRefGoogle Scholar
Ganote, C. E., Grantham, J. J., Moses, H. L., Burg, M. B. and Orloff, J. (1968) Ultrastructural studies of vasopressin effect on isolated perfused renal collecting tubules of the rabbit. Journal of Cell Biology, 36: 355–367.CrossRefGoogle ScholarPubMed
Guild, S. R. (1927) Circulation of endolymph. American Journal of Anatomy, 39: 57–81.CrossRefGoogle Scholar
Hallpike, C. S. and Cairns, H. (1938) Observations on the pathology of Meniere's syndrome. Journal of Laryngology and Otology, 53: 625–655.CrossRefGoogle Scholar
Harrison, M. S. and Naftalin, L. (1968) Meniere's disease: mechanism and management. Charles C. Thomas, Springfield, Illinois.Google Scholar
Juhn, S. K. and Ryback, L. (1981) Nature of blood-labyrinth barrier. In Vosteen, K. H., Pfaltz, C. R. et al. (eds.): Meniere's disease. Pathogenesis, diagnosis and treatment. Stuttgart, New York, George Thieme, 59–67.Google Scholar
Juhn, S. K. (1984) Inner ear fluids dynamics and endolymphatic hydrops. Acta Otolaryngologica Supplement 406: 26–30.Google ScholarPubMed
Kimura, R. S. and Schuknecht, H. F. (1965) Membranous hydrops of the inner ear of the guinea-pig after obliteration of the endolymphatic sac. Practical Otorhinolaryngology, 27: 343–354.Google Scholar
Lundquist, P.-G., Kimura, R. S. and Wersäll, J. (1964) Experiments in endolymph circulation. Acta Otolaryngologica Supplement, 188: 198–201.CrossRefGoogle ScholarPubMed
Lundquist, P.-G. (1965) The endolymphatic duct and sac in the guinea-pig. An electron microscopic and experimental investigation. Acta Otolaryngologica, Supplement 201: 1–108.Google Scholar
Lundquist, P.-G. (1976) Aspects on endolymphatic sac morphology and function. Archives of Otorhinolaryngology, 212: 231–240.CrossRefGoogle ScholarPubMed
Oufara, S., Barr, H., Rouanet, J.-L. and Chatonnet, J. (1987) Adaptation to extreme ambient temperatures in cold-acclimated gerbils and mice. The American Journal of Physiology, R39–R45.Google ScholarPubMed
Rask-Andersen, H., Bredberg, G. and Stahle, J. (1981a) Structure and function of the endolymphatic duct, in Vosteen, K. H., Shuknecht, H. F., Pfaltz, C. R. et al. , (eds.): Meniere's disease. Pathogenesis, diagnosis and treatment. stuttgart, New York, George Thieme, 99–109.Google Scholar
Rask Andersen, H., Bredberg, G., Lyttkens, L. and Loof, G. (1981b) The function of the endolymphatic duct. An experimental study using ionic lanthanum as a tracer. A preliminary report. Annals of New York Academy of Sciences, 374: 11–19.CrossRefGoogle ScholarPubMed
Rask-Andersen, H., Erwall, C., Steel, K. P. and Friberg, U. (1987) The endolymphatic sac in a mouse mutant with cochleosaccular degeneration. Electrophysiological and ultrastructural correlations. Hearing Research, 26: 177–190.CrossRefGoogle Scholar
Schuknecht, H. F., Northop, B. A. and Igarashi, M. (1968) Cochlear pathology after destruction of the endolymphatic sac in the cat. Acta Otolaryngologica, 65: 479–487.CrossRefGoogle ScholarPubMed
Sziklai, I., Ferrary, E., Sterkers, O. and Amiel, C. (1987) Vasopressin entry into the inner ear fluids of the rat. Hearing Research, 29: 245–250.CrossRefGoogle ScholarPubMed
Thompson, C. J., Bland, J., Burd, J. and Baylis, P. H. (1986) The osmotic thresholds for thirst and vasopressin release are similar in healthy man. Clinical Science, 71: 651–656.CrossRefGoogle ScholarPubMed
Wackym, P. A., Friberg, U., Bagger-Sjöbäck, D. and Rask-Andersen, H. (1986) Human endolymphatic duct: possible mechanisms of endolymph outflow. Annals of Otology, Rhinology and Laryngology, 95: 409–414.CrossRefGoogle ScholarPubMed
Woolf, N. K. and Ryan, A. F. (1984) The development of auditory function in the cochlea of the mongolian gerbil. Hearing Research, 13: 277–283.CrossRefGoogle ScholarPubMed