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Analysis of lectin receptors in normal nasal mucosa, nasal polyp, inverted papilloma and papillary adenocarcinoma

Published online by Cambridge University Press:  29 June 2007

Hai Huang ,
Desheng Jing ,
Zhaoji Li ,
Shuimiao Zhou ,
Shizhi Xiao ,
Dalie Ma  and
Rongzhou Zhang
Hai Huang*
Affiliation:
Department of Otolaryngology, Changhai Hospital, Shanghai, China.
Desheng Jing
Affiliation:
Department of Otolaryngology, Changhai Hospital, Shanghai, China.
Zhaoji Li
Affiliation:
Department of Otolaryngology, Changhai Hospital, Shanghai, China.
Shuimiao Zhou
Affiliation:
Department of Otolaryngology, Changhai Hospital, Shanghai, China.
Shizhi Xiao
Affiliation:
Department of Otolaryngology, Changhai Hospital, Shanghai, China.
Dalie Ma
Affiliation:
Department of Pathology, Changhai Hospital, Shanghai, China.
Rongzhou Zhang
Affiliation:
Department of Pathology, Changhai Hospital, Shanghai, China.
*
Hai Huang, Department of Otolaryngology, Changhai Hospital. 174 Changhai Road, Shanghai, PR China 200433.
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Abstract

In order to investigate the changes in glycoprotein structure in the process of cellular differentiation of the nasal mucosa, formalin-fixed, paraffin-embedded biopsy specimens of normal nasal mucosae, nasal polyps, inverted papillomas and papillary adenocarcinomas were analysed by the Avidin Biotin-Peroxidase Complex technique for the demonstration of peanut agglutinin (PNA) receptors, concanavalin ensifomis agglutinin (ConA) receptors, ulex europeaus agglutinin (UEA-I) receptors, wheat germ agglutinin (WGA) receptors, carcino-embryonic antigen (CEA) and keratin. The quantity and distribution of PNA receptors, ConA receptors, UEA-I receptors and CEA were different, in relation to the varying pathological changes. The results suggest that the glycoprotein structure in the cells of the nasal mucosa will change following their differentiation and malignant transformation, which may be helpful in establishing the diagnosis.

Keywords

Receptors, mitogenNasal neoplasms

Information

Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 107 , Issue 7 , July 1993 , pp. 600 - 602
Copyright
Copyright © JLO (1984) Limited 1993

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