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Oncogenic impact of human papilloma virus in head and neck cancer

Published online by Cambridge University Press:  02 June 2010

C B Heffernan ,
J P O'Neill  and
C Timon
C B Heffernan*
Affiliation:
The Royal Victoria Eye and Ear Hospital, Adelaide Road, Dublin, Ireland
J P O'Neill
Affiliation:
The Royal Victoria Eye and Ear Hospital, Adelaide Road, Dublin, Ireland
C Timon
Affiliation:
The Royal Victoria Eye and Ear Hospital, Adelaide Road, Dublin, Ireland
*
Address for correspondence: Ms Colleen Heffernan, 172 Viewmount Park, Waterford, Ireland. E-mail: Heffernan_colleen@hotmail.com
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Abstract

There is considerable debate within the literature about the significance of human papilloma virus in head and neck squamous cell carcinoma, and its potential influence on the prevention, diagnosis, grading, treatment and prognosis of these cancers. Cigarette smoking and alcohol consumption have traditionally been cited as the main risk factors for head and neck cancers. However, human papilloma virus, normally associated with cervical and other genital carcinomas, has emerged as a possible key aetiological factor in head and neck squamous cell carcinoma, especially oropharyngeal cancers. These cancers pose a significant financial burden on health resources and are increasing in incidence. The recent introduction of vaccines targeted against human papilloma virus types 16 and 18, to prevent cervical cancer, has highlighted the need for ongoing research into the importance of human papilloma virus in head and neck squamous cell carcinoma.

Keywords

Human Papilloma VirusHead And Neck NeoplasmsPharynx NeoplasmsSquamous Carcinoma

Information

Type
Review Article
Information
The Journal of Laryngology & Otology , Volume 124 , Issue 9 , September 2010 , pp. 941 - 944
Copyright
Copyright © JLO (1984) Limited 2010

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References

1Vokes, EE, Weichselbaum, RR, Lippman, SM, Hong, WK. Head and Neck Cancer. N Engl J Med 1993;328:184–94Google Scholar
2Kreimer, AR, Clifford, GM, Boyle, P, Franceschi, S. Human papillomavirus types in head and neck squamous cell carcinomas worldwide: a systematic review. Cancer Epidemiol Biomarkers Prev 2005;14:467–75Google Scholar
3Hu, D, Goldie, SJ. The economic burden of noncervical human papillomavirus disease in the United States. Am J Obstet Gynecol 2008;198;487–8Google Scholar
4Mineta, H, Ogino, T, Amano, HM, Ohkawa, Y, Araki, K, Takebayashi, S et al. Human papilloma virus (HPV) type 16 and 18 detected in head and neck squamous cell carcinoma. Anticancer Res 1998;18:4765–8Google Scholar
5Franceschi, S, Munoz, N, Bosch, XF, Snijders, PJ, Walboomers, JM. Human papillomavirus and cancers of the upper aerodigestive tract: a review of epidemiological and experimental evidence. Cancer Epidemiol Biomarkers Prev 1995;5:567–75Google Scholar
6Syrjanen, S. HPV infections and tonsillar carcinoma. J Clin Pathol 2004;57:449–55Google Scholar
7Fakhry, C, Westra, WH, Li, S, Cmelak, A, Ridge, JA, Pinto, H et al. Improved survival of patients with human papillomavirus-positive head and neck squamous cell carcinoma in a prospective clinical trial. J Natl Cancer Inst 2008;100:261–9Google Scholar
8Campisi, G, Giovannelli, L. Controversies surrounding human papilloma virus infection, head & neck vs oral cancer, implications for prophylaxis and treatment. Head Neck Oncol 2009;1:8Google Scholar
9Yamada, T, Manos, MM, Peto, J, Greer, CE, Munoz, N, Bosch, FX et al. Human papillomavirus type 16 sequence variation in cervical cancers: a worldwide perspective. J Virol 1997;71:2463–72Google Scholar
10Slebos, RJ, Yi, Y, Ely, K, Carter, J, Evjen, A, Zhang, X et al. Gene expression differences associated with human papillomavirus status in head and neck squamous cell carcinoma. Clin Cancer Res 2006;12:701–9Google Scholar
11Chaudhary, A, Singh, M, Sundaram, S, Mehrotra, R. Role of human papillomavirus and its detection in potentially malignant and malignant head and neck lesions: updated review. Head Neck Oncol 2009;1:22Google Scholar
12Hafkamp, HC, Speel, EJ, Haesevoets, A, Bot, FJ, Dinjens, WN, Ramaekers, FC, Hopman, AH, Manni, JJ. A subset of head and neck squamous cell carcinomas exhibits integration of HPV 16/18 DNA and overexpression of p16 and p53 in the absence of mutations in p53 exons 5-8. Int J Cancer 2003;107:394–400Google Scholar
13Mork, J, Lie, AK, Glattre, E, Hallmans, G, Jellum, E, Koskela, P, Møller, B, Pukkala, E, Schiller, JT, Youngman, L, Lehtinen, M, Dillner, J. Human papillomavirus infection as a risk factor for squamous-cell carcinoma of the head and neck. N Engl J Med 2001;344:1125–31Google Scholar
14Ringstrom, E, Peters, E, Hasegawa, M, Posner, M, Liu, M, Kelsey, KT. Human papillomavirus type 16 and squamous cell carcinoma of the head and neck. Clin Cancer Res 2002;8:3187–92Google Scholar
15Gillison, ML, D'Souza, G, Westra, W, Sugar, E, Xiao, W, Begum, S, Viscidi, R. Distinct risk factor profiles for human papillomavirus type 16-positive and human papillomavirus type 16-negative head and neck cancers. J Natl Cancer Inst 2008;100:407–20CrossRefGoogle ScholarPubMed
16Giovannelli, L, Campisi, G, Lama, A, Giambalvo, O, Osborn, J, Margiotta, V et al. Human papillomavirus DNA in oral mucosal lesions. J Infect Dis 2002;185:833–6Google Scholar
17Ha, PK, Pai, SI, Westra, WH, Gillison, ML, Tong, BC, Sidransky, D et al. Real-time quantitative PCR demonstrates low prevalence of human papillomavirus type 16 in premalignant and malignant lesions of the oral cavity. Clin Cancer Res 2002;8:1203–9Google ScholarPubMed
18Devaraj, K, Gillison, ML, Wu, TC. Development of HPV vaccines for HPV-associated head and neck squamous cell carcinoma. Crit Rev Oral Biol Med 2003;14:345–62Google Scholar
19D'Souza, G, Agrawal, Y, Halpern, J, Bodison, S, Gillison, ML. Oral sexual behaviors associated with prevalent oral human papillomavirus infection. J Infect Dis 2009;199:1263–9Google Scholar
20Gillison, ML. Human papillomavirus-related diseases: oropharynx cancers and potential implications for adolescent HPV vaccination. J Adolesc Health 2008;43 (suppl 1):S52–60CrossRefGoogle ScholarPubMed
21Yan, J, Reichenbach, DK, Corbitt, N, Hokey, DA, Ramanathan, MP, McKinney, KA et al. Induction of antitumor immunity in vivo following delivery of a novel HPV-16 DNA vaccine encoding an E6/E7 fusion antigen. Vaccine 2009;27:431–40Google Scholar
22Lee, DW, Anderson, ME, Wu, S, Lee, JH. Development of an adenoviral vaccine against E6 and E7 oncoproteins to prevent growth of human papillomavirus-positive cancer. Arch Otolaryngol Head Neck Surg 2008;134:1316–23Google Scholar
23Klozar, J, Kratochvil, V, Salakova, M, Smahelova, J, Vesela, E, Hamsikova, E et al. HPV status and regional metastasis in the prognosis of oral and oropharyngeal cancer. Eur Arch Otorhinolaryngol 2008;265:S75–82Google Scholar
24Mendenhall, WM, Logan, HL. Human papillomavirus and head and neck cancer. Am J Clin Oncol 2009 Jul 31. [Epub ahead of print]Google Scholar