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Serum antibodies against respiratory tract viruses: A prospective three-year follow-up from birth

Published online by Cambridge University Press:  29 June 2007

G. Harsten ,
K. Prellner ,
B. Löfgren ,
J. Heldrup ,
O. Kalm  and
R. Kornfält
G. Harsten*
Affiliation:
Department of Oto-Rhino-Laryngology, University Hospital, Lund, Sweden.
K. Prellner
Affiliation:
Department of Oto-Rhino-Laryngology, University Hospital, Lund, Sweden.
B. Löfgren
Affiliation:
Department of Medical Mircobiology, University Hospital, Lund, Sweden.
J. Heldrup
Affiliation:
Department of Paediatrics, University Hospital, Lund, Sweden.
O. Kalm
Affiliation:
Department of Oto-Rhino-Laryngology, University Hospital, Lund, Sweden.
R. Kornfält
Affiliation:
Department of Paediatrics, University Hospital, Lund, Sweden.
*
Dr. Göran Harsten, M.D., Department of Oto-Rhino-Laryngology, University Hospital, S-221 85 LUND, Sweden.
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Abstract

Acute otitis media (AOM) has been epidemiologically related to viral respiratory tract infections, and viral antigens have also been detected in middle ear secretion in some AOM episodes. Successive serum samples from children followed prospectively for three years from birth were analysed for IgG antibodies against respiratory syncytial virus (RSV), adenoviruses and influenza A virus.

Values from serum antibody activity gradually decreased during the first six months of life, followed by a gradual increase. Various relationships were found to obtain between age and the increases of antibody activity against the different viruses. Thus, three quarters of those tested had manifested increased antibody activity against RSV by 18 months of age, and against adenoviruses by 30 months of age. No increase of antibody activity against influenza A was noted before 12 months of age, and then only seen in two thirds of those tested during the entire three-year observation period. With regard to age, however, the proportion of children with increased antibody activity to RSV, adenoviruses or influenza A virus did not differ between otitis-prone and non-otitis-prone children. Thus, as compared to non-otitis-prone children, development of the ability to produce antibodies against these viruses was not found to be delayed in otitis-prone children.

Information

Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 103 , Issue 10 , October 1989 , pp. 904 - 908
Copyright
Copyright © JLO (1984) Limited 1989

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References

Blomberg, J., Nilsson, I. and Andersson, M. (1983) Viral antibody screening system that uses a standardized single dilution immunoglobulin G enzyme immunoassay with multiple antigens. Journal of Clinical Microbiology, 17: 1081–1091.CrossRefGoogle ScholarPubMed
Freijd, A., Hammarström, L., Persson, M. A. A. and Smith, C. I. E. (1984) Plasma antipneumococcal antibody activity of the IgG class and subclasses in otitis prone children. Clinical and Experimental Immunology, 56: 233–238.Google ScholarPubMed
Harsten, G., Prellner, K., Heldrup, J., Kalm, O. and Kornfält, R. (1989) Recurrent acute otitis media. A prospective study of children during the first three years of life. Acta OtoLaryngologica, 107: 111–119.CrossRefGoogle ScholarPubMed
Henderson, F. W., Collier, A. M., Sanyal, M. A., Watkins, J. M., Fairclough, D. L., Clyde, W. A. and Denny, F. W. (1982) A longitudinal study of respiratory viruses and bacteria in the etiology of acute otitis media with effusion. New England Journal of Medicine, 306: 1377–1383.CrossRefGoogle ScholarPubMed
Hornsleth, A., Bech-Thomsen, N. and Friis, B. (1985) Detection of RS-virus IgG-subclass-specific antibodies: variation according to age in infants and small children and diagnostic value in RS-virus-infected small infants. Journal of Medical Virology, 16: 329–335.CrossRefGoogle ScholarPubMed
Johansson, S. G. O. and Berg, T. (1967) Immunoglobulin levels in healthy children. Acta Paediatrica Scandinavica, 56: 572–579.CrossRefGoogle ScholarPubMed
Kalm, O., Prellner, K. and Pedersen, F. K. (1984) Pneumococcal antibodies in families with recurrent otitis media. International Archives of Allergy and Applied Immunology, 75: 139–142.CrossRefGoogle ScholarPubMed
Kalm, O., Prellner, K., Freijd, A. and Rynnel-Dagöö, B. (1986) Antibody activity before and after pneumococcal vaccination of otitis-prone and non-otitis-prone children. Acta Oto-Laryngologica, 101: 467–474.CrossRefGoogle ScholarPubMed
Karma, P., Palva, T., Kouvalainen, K., Kärjä, J., Mäkelä, P. H., Prinssi, V-P., Ruuskanen, O. and Launiala, K. (1987) Finnish approach to the treatment of acute otitis media. Report of the Finnish consensus conference. Annals of Otology, Rhinology and Laryngology, 96 (Supplement 129).CrossRefGoogle Scholar
Klein, J. O. (1980) Microbiology of otitis media. Annals of Otology, Rhinology and Laryngology, 89 (Supplement 68): 98–101.CrossRefGoogle ScholarPubMed
Klein, B. S., Dollete, F. R. and Yolken, R. H. (1982) The role of respiratory syncytial virus and other viral pathogens in acute otitis media. Journal of Pediatrics, 101: 16–20.CrossRefGoogle ScholarPubMed
Parrott, R. H., Kim, H. W., Arrobio, J. O., Hodes, D. S., Murphy, B. R., Brandt, C. D., Camargo, E. and Chanock, R. M. (1973) Epidemiology of respiratory syncytial virus infection in Washington D.C.II. Infection and disease with respect to age, immunologic status, race and sex. American Journal of Epidemiology, 98: 289–300.CrossRefGoogle ScholarPubMed
Pelton, S. I., Sjber, G. R. and Teele, D. W. (1987) Immunoglobulin levels and immunoglobulin allotypes in children with recurrent otitis media. In: Abstracts of the Fourth International Symposium on Recent Advances in Otitis Media, p. 44.Google Scholar
Prellner, K., Kalm, O. and Pedersen, F. K. (1984) Pneumococcal antibodies and complement during and after periods of recurrent otitis. International Journal of Pediatric Otorhinolaryngology, 7: 39–49.CrossRefGoogle ScholarPubMed
Prellner, K., Kalm, O., Harsten, G., Heldrup, J. and Oxelius, V-A.Pneumococcal serum antibody concentrations during the first three years of life: a study of otitis-prone and non-otitis-prone children. International Journal of Pediatric Otorhinolaryngology (accepted for publication).Google Scholar
Prellner, K., Harsten, G.Löfgren, B., Christenson, B. and Heldrup, J.Responses to rubella, tetanus and diphtheria vaccines compared in otitis-prone and non-otitis-prone children. Annals of Otology, Rhinology and Laryngology (submitted for publication).Google Scholar
Sarkkinen, H., Ruuskanen, O., Meurman, O., Puhakka, H., Virolainen, E. and Eskola, J. (1985) Identification of respiratory virus antigens in middle ear fluids of children with acute otitis media. Journal of Infectious Diseases, 151: 444–448.CrossRefGoogle ScholarPubMed
Schopfer, K., Germann, D., Eggenberger, K., Bächler, A. and Wunderli, W. (1986) Virale respiratorische Infekionen bei Kinder: neue diagnostische Methode zur Früherfassung. Schweizerische Medizinische Wochenschrift, 116: 502–507 (in German, summary in English).Google Scholar
Shurin, P. A., Pelton, S. I., Tager, I. B. and Kasper, D. L. (1980) Bacterial antibody and susceptibility to otitis media caused by nontypable strains Haemophilus influenzae. Journal of Pediatrics, 97: 364–369.CrossRefGoogle ScholarPubMed
Shurin, P. A., Marchant, C. D. and Howie, V. M. (1984) Bactericidal antibody to antigenically distinct nontypable strains of Hemophilus influenzae isolated from acute otitis media. In: Recent Advances in Otitis Media with Effusion (Lim, D. J., Bluestone, C. D., Klein, J. O. and Nelson, J. D., eds.), pp. 155–157, B.C. Decker Inc., Philadelphia, Toronto.Google Scholar