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Resilience of DNA chains to molecular fracture after PCR heating cycles and implications on PCR reliability – EXPRESSION OF CONCERN

Published online by Cambridge University Press:  04 August 2025

Roberto Serpieri Open the ORCID record for Roberto Serpieri [Opens in a new window]  and
Fabio Franchi
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Abstract

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Information

Type
Expression Of Concern
Information
Quarterly Reviews of Biophysics , Volume 58 , 2025 , e16
Copyright
© The Author(s), 2025. Published by Cambridge University Press

The Editor in Chief wishes to alert readers about limitations and concerns regarding the above article. Whilst the Editor in Chief still considers the article to provide a valuable contribution to the scientific discourse from a historical perspective, readers should be aware that some of the claims made in the article may not reflect current understanding of PCR DNA amplification. The authors have clearly set out to review older studies and have shone a light on some important concerns for the structural integrity of DNA, but have not included more recent studies. A more detailed critique of the article has been published by Beyer and Konrad.

(Konrad H, Beyer A. How reliable is PCR? A mini review. Quarterly Reviews of Biophysics. 2025;58:e15. doi:10.1017/S0033583525100024).

The authors do not agree with this Expression of Concern.

References

Serpieri, R and Franchi, F (2024) Resilience of DNA chains to molecular fracture after PCR heating cycles and implications on PCR reliability. Quarterly Reviews of Biophysics 57, e8. https://doi.org/10.1017/S0033583524000064CrossRefGoogle ScholarPubMed