Hostname: page-component-6766d58669-76mfw Total loading time: 0 Render date: 2026-05-24T13:13:41.835Z Has data issue: false hasContentIssue false
  • English
  • Français

Ossifying fibromyxoid tumour of the sphenoid sinus

Published online by Cambridge University Press:  20 October 2009

S D Shetty ,
R J Salib ,
S B Nair ,
N Mathad  and
J Theaker
S D Shetty
Affiliation:
Department of Otorhinolaryngology, Southampton University Hospitals NHS Trust, UK
R J Salib*
Affiliation:
Department of Otorhinolaryngology, Southampton University Hospitals NHS Trust, UK
S B Nair
Affiliation:
Department of Otorhinolaryngology, Southampton University Hospitals NHS Trust, UK
N Mathad
Affiliation:
Department of Neurosurgery, Southampton University Hospitals NHS Trust, UK
J Theaker
Affiliation:
Department of Histopathology, Southampton University Hospitals NHS Trust, UK
*
Address for correspondence: Mr R J Salib, ENT Department, Southampton University Hospitals NHS Trust, Tremona Road, Southampton SO16 6YD, UK. Fax: 02380794868 E-mail: rjs4@soton.ac.uk
Get access Rights & Permissions [Opens in a new window]

Abstract

Introduction:

Ossifying fibromyxoid tumour is a recently described, rare but morphologically distinctive soft tissue neoplasm characterised by a combination of myxoid and/or fibrous stroma with areas of ossification. Although most authors postulate a neuroectodermal origin for this peculiar tumour, there is no agreement in the literature regarding its histopathogenesis. To our knowledge, this is the first reported case of ossifying fibromyxoid tumour involving the sphenoid sinus.

Histological findings:

Tumour of low cell density, composed of small, spindle-shaped or stellate cells with small, irregular nuclei set in a fibromyxoid stroma.

Management:

Following discussion at the skull base multidisciplinary team meeting, a combined surgical team including an otorhinolaryngologist and a neurosurgeon carried out resection of the lesion, using an endoscopic transnasal approach, followed by reconstruction of the defect.

Conclusions:

An awareness of the distinctive histopathological features of ossifying fibromyxoid tumour, and of its clinical effects, is crucial to establishing a definitive diagnosis and thereby instituting appropriate management. This case report also reinforces the evolving role of the endoscopic transnasal approach in the management of inflammatory and neoplastic disease involving the skull base. This is increasingly being made possible by close collaboration between multiple surgical specialties, including otorhinolaryngology and neurosurgery.

Keywords

NasalParanasal SinusesTumourSkull BasePathologyTreatmentEndoscopic Surgery

Information

Type
Clinical Records
Information
The Journal of Laryngology & Otology , Volume 124 , Issue 4 , April 2010 , pp. 437 - 440
Copyright
Copyright © JLO (1984) Limited 2009

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

Article purchase

Temporarily unavailable

References

1 Enzinger, FM, Weiss, SW, Liang, CY. Ossifying fibromyxoid tumor of soft parts. Am J Surg Pathol 1989;13:817–27CrossRefGoogle ScholarPubMed
2 Fisher, C, Hedges, M, Weiss, SW. Ossifying fibromyxoid tumor of soft parts with stromal cyst formation and ribosome-lamella complexes. Ultrastruct Pathol 1994;18:593–600CrossRefGoogle ScholarPubMed
3 Williams, SB, Ellis, GL, Meis, JM, Heffner, DK. Ossifying fibromyxoid tumour (of soft parts) of the head and neck: a clinicopathological and immunohistochemical study of nine cases. J Laryngol Otol 1993;107:75–80CrossRefGoogle ScholarPubMed
4 Folpe, AL, Weiss, SW. Ossifying fibromyxoid tumor of soft parts: a clinicopathologic study of 70 cases with emphasis on atypical and malignant variants. Am J Surg Pathol 2003;27:421–31CrossRefGoogle Scholar
5 Blum, A, Back, W, Naim, R, Hormann, K, Riedal, F. Ossifying fibromyxoid tumor of the nasal septum. Auris Nasus Larynx 2006;33:325–7CrossRefGoogle ScholarPubMed
6 Al-Mazrou, KA, Mansoor, A, Payne, M, Richardson, MA. Ossifying fibromyxoid tumor of the ethmoid sinus in a newborn: report of a case and literature review. Int J Pediatr Otorhinolaryngol 2004;68:225–30CrossRefGoogle Scholar
7 Sovani, V, Velagaleti, GVN, Filipowicz, E, Gatalica, Z, Knisely, AS. Ossifying fibromyxoid tumor of soft parts: report of a case with novel cytogenetic findings. Cancer Genet Cytogenet 2001;127:1–6CrossRefGoogle ScholarPubMed
8 Nishio, J, Iwaski, H, Ohjimi, Y, Ishiguro, M, Isayama, T, Naito, M et al. Ossifying fibromyxoid tumor of soft parts, cytogenetic findings. Cancer Genet Cytogenet 2002;133:124–8CrossRefGoogle ScholarPubMed
9 Kilpatrick, SE, Ward, WG, Mozes, M, Miettinen, M, Fukunaga, M, Fletcher, CDM. Atypical and malignant variants of ossifying fibromyxoid tumor: clinicopathological analysis of six cases. Am J Surg Pathol 1995;19:1039–46CrossRefGoogle ScholarPubMed
10 Schofield, JB, Krausz, T, Stamp, GWH, Fletcher, CDM, Fisher, C, Azzopardi, JG. Ossifying fibromyxoid tumor of soft parts: immunohistochemical and ultrastructural analysis. Histopathology 1993;22:101–12CrossRefGoogle Scholar
11 Thompson, J, Castillo, M, Reddick, RL, Smith, JK, Shockley, W. Nasopharyngeal nonossifying variant of ossifying fibromyxoid tumor: CT and MR findings. AJNR Am J Neuroradiol 1995;16:1132–4Google ScholarPubMed
12 Oda, N, Yasui, W, Ito, H, Tahara, E. Ossifying fibromyxoid tumour of soft parts: a case report. Jpn J Clin Oncol 1993;23:64–8Google ScholarPubMed
13 Carrau, RL, Kassam, AB, Snyderman, CH, Duvvuri, U, Mintz, A, Gardner, P. Endoscopic transnasal anterior skull base resection for the treatment of sinonasal malignancies. Operative Techniques in Otolaryngology 2006;17:102–10CrossRefGoogle Scholar
14 Snyderman, CH, Carrau, RL, Kassam, AB, Zanation, A, Prevedello, D, Gardner, P et al. Endoscopic skull base surgery: principles of endonasal oncological surgery. J Surg Oncol 2008;97:658–64CrossRefGoogle ScholarPubMed