To the Editor—We thank Eric Schlote, CEO of Synexis Biodefense Systems, for his letter regarding our article, “Evaluation of dilute hydrogen peroxide technology for continuous room decontamination of multidrug-resistant organisms.”^{Reference Rutala, Kanamori, Gergen, Sickbert-Bennett, Anderson, Sexton and Weber1} As noted in our paper, hospital room environmental surfaces are frequently contaminated and serve as a source for healthcare MDROs. Contact with these contaminated surfaces may result in hand or glove contamination of healthcare personnel that can be transferred to patients. Development of a validated effective method for continuous room disinfection method would provide an important tool for decreasing surface contamination with MDROs and healthcare-associated pathogens.

We acknowledge that the device we tested may not be the device currently marketed by Synexis Biodefense Systems. However, when we conducted our study, we were told that we were studying the device that would be marketed.

We take exception with Mr Schloteʼs claim that the dilute hydrogen peroxide system marketed by Synexis Biodefense Systems has been validated. Only a single abstract has been published,^{Reference Herman, Hess and Cerra2} and no-peer reviewed, published studies have validated that use of this device can effectively provide continuous decontamination of the environment (eg, surfaces). Furthermore, the one abstract that has been published has substantial limitations: (1) the study used a before–after study design, a relatively weak epidemiologic method; (2) the study assessed the device for only 7 days after installation; (3) the researchers did not measure the concentration of the hydrogen peroxide in the test rooms; and (4) no statistical evaluation was provided. The authors of this abstract recommended further study. Even if a statistical reduction of surface contamination is demonstrated, this method of continuous room disinfection needs to be validated (1) to decrease healthcare-associated infections (HAIs), (2) to be safe for patients and healthcare personnel, and (3) to be cost-effective.

Although we were unable to perform additional studies due to the lack of laboratory capabilities, we have been in contact with colleagues interested in further studies of this methodology. We made several recommendations to them: (1) install the test device consistent with the manufacturerʼs recommendations; (2) monitor the concentration of hydrogen peroxide at a low concentration produced both at the unit exhaust and at room surfaces; (3) assess relevant healthcare-associated pathogens; (4) use appropriate controls (eg, similar rooms without the test device); (5) monitor microbial reduction quantitatively; (6) monitor compliance with room disinfection (for clinical trials) using a method such as fluorescent dye; (7) perform room cleaning and disinfection per CDC recommendations; and finally (8) assess the impact of HAI rates.

We agree that further studies of self-disinfecting and continuous room disinfection methods are highly important to public health.