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Chapter 7 - Understanding the Use of Antimicrobial Agents

Published online by Cambridge University Press:  19 December 2019

Luke S. P. Moore
Affiliation:
Imperial College London
James C. Hatcher
Affiliation:
Great Ormond Street Hospital for Children
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Summary

A basic understanding of the mechanism of action and indication for antimicrobials is held by most prescribers. The key properties of different classes of antimicrobials, their anticipated side effects and the spectrum of activity against different pathogens is inherent in most undergraduate and post-graduate medical curricula. Practitioners in the fields of infectious diseases, microbiology and virology must have a firm grasp of this knowledge, and should be able to apply it to patients with bacterial, viral, fungal or parasitic infections. They must be able to integrate this knowledge with the pharmacokinetic properties of the antimicrobials, and should be able to adapt this in differing patient populations including those with renal impairment or on renal replacement therapy and those with allergies or other host factors.

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