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Biophysics of viral infectivity: matching genome length with capsid size

Published online by Cambridge University Press:  21 April 2008

Elmar Nurmemmedov ,
Martin Castelnovo ,
Carlos Enrique Catalano  and
Alex Evilevitch
Elmar Nurmemmedov
Affiliation:
Department of Biochemistry, Center for Chemistry and Chemical Engineering, Lund University, Lund, Sweden
Martin Castelnovo
Affiliation:
Laboratoire Joliot-Curie – Laboratoire de Physique, Ecole Normale Superieure de Lyon, Lyon, France
Carlos Enrique Catalano
Affiliation:
Department of Medicinal Chemistry, University of Washington School of Pharmacy, Seattle, WA, USA
Alex Evilevitch*
Affiliation:
Department of Biochemistry, Center for Chemistry and Chemical Engineering, Lund University, Lund, Sweden
*
*Author for correspondence: Dr A. Evilevitch, Department of Biochemistry, Center for Chemistry and Chemical Engineering, Lund University, Box 124, S-221 00, Lund, Sweden.  Tel.: +46 46 222 3291; Fax: +46 46 222 4116; Email: Alex.Evilevitch@biochemistry.lu.se
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Abstract

In this review, we discuss recent advances in biophysical virology, presenting experimental and theoretical studies on the physical properties of viruses. We focus on the double-stranded (ds) DNA bacteriophages as model systems for all of the dsDNA viruses both prokaryotic and eukaryotic. Recent studies demonstrate that the DNA packaged into a viral capsid is highly pressurized, which provides a force for the first step of passive injection of viral DNA into a bacterial cell. Moreover, specific studies on capsid strength show a strong correlation between genome length, and capsid size and robustness. The implications of these newly appreciated physical properties of a viral particle with respect to the infection process are discussed.

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Type
Review Article
Information
Quarterly Reviews of Biophysics , Volume 40 , Issue 4 , November 2007 , pp. 327 - 356
Copyright
Copyright © Cambridge University Press 2008

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