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Expression of cluster of differentiation 9 glycoprotein in benign and malignant parotid gland tumours

Published online by Cambridge University Press:  22 May 2009

K Sakamoto ,
T Ono ,
Y Nakamura ,
H Harada  and
T Nakashima
K Sakamoto*
Affiliation:
Department of Otolaryngology-Head & Neck Surgery, Kurume University School of Medicine, Kurume, Japan
T Ono
Affiliation:
Department of Otolaryngology-Head & Neck Surgery, Kurume University School of Medicine, Kurume, Japan
Y Nakamura
Affiliation:
Department of Pathology, St Mary's Hospital, Kurume, Japan.
H Harada
Affiliation:
Department of Pathology, Kurume University School of Medicine, Kurume, Japan
T Nakashima
Affiliation:
Department of Otolaryngology-Head & Neck Surgery, Kurume University School of Medicine, Kurume, Japan
*
Address for correspondence: Dr Kikuo Sakamoto, Department of Otolaryngology-Head and Neck Surgery, Kurume University School of Medicine, 67 Asahi-machi, Kurume 830-0011, Japan. Fax: +81 942 37 1200 E-mail: orlkaku@med.kurume-u.ac.jp
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Abstract

Objectives:

This study aimed to clarify the significance of cluster of differentiation 9 glycoprotein gene expression in human parotid gland tumours.

Methods:

We retrospectively analysed immunohistochemical staining for cluster of differentiation 9 glycoprotein in parotid gland tumours.

Results:

Cluster of differentiation 9 glycoprotein was consistently detected in the normal parotid gland. Regarding benign parotid gland tumours, cluster of differentiation 9 glycoprotein was present in 13 of 18 pleomorphic adenomas, in all Warthin tumours tested (21/21) and in all cases of basal cell adenoma tested (four of four). In contrast, positive staining for cluster of differentiation 9 glycoprotein was less often observed in malignant parotid tumours. Cluster of differentiation 9 glycoprotein was present in 11 of 14 mucoepidermoid carcinomas, in two of five acinic cell carcinomas and in two of five adenoid cystic carcinomas.

Conclusions:

There was a statistically significantly reduced expression of cluster of differentiation 9 glycoprotein in malignant parotid gland tumours, compared with benign parotid gland tumours (p < 0.05). These results suggest that a low level of cluster of differentiation 9 glycoprotein expression in parotid gland tumours may be associated with malignancy.

Keywords

Parotid Gland TumorsCD9Immunohistochemistry

Information

Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 123 , Supplement S31 , May 2009 , pp. 58 - 63
Copyright
Copyright © JLO (1984) Limited 2009

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