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Integrating safety planning, problem-solving therapy and peer support for suicide prevention among adolescents living with HIV in Malawi: An application of the ADAPT-ITT adaptation framework

Published online by Cambridge University Press:  18 May 2026

Melissa Ann Stockton*
Affiliation:
University of Pennsylvania , USA The University of North Carolina at Chapel Hill , USA
Katherine Waddell
Affiliation:
UNC Project-Malawi, Malawi
Nivedita L. Bhushan
Affiliation:
RTI International, USA
Steven Mphonda
Affiliation:
UNC Project-Malawi, Malawi
Victoria Constantine
Affiliation:
University of Pennsylvania , USA
Charles Masulani-Mwale
Affiliation:
Saint John of God College of Health Sciences, Malawi
James January
Affiliation:
Psychiatry, University of KwaZulu-Natal, South Africa Psychiatry & Mental Health, Kamuzu University of Health Sciences , Malawi
Greg Brown
Affiliation:
University of Pennsylvania , USA
Michael Udedi
Affiliation:
Government of Malawi Ministry of Health, Malawi
Jeromy Nyirenda
Affiliation:
UNC Project-Malawi, Malawi
Ezekiel Mahuka
Affiliation:
UNC Project-Malawi, Malawi
Brian Pence
Affiliation:
The University of North Carolina at Chapel Hill , USA
Bradley Gaynes
Affiliation:
The University of North Carolina at Chapel Hill , USA
Matthew T. K. Owusu
Affiliation:
The University of North Carolina at Chapel Hill , USA
Ruth Verhey
Affiliation:
Friendship Bench, Zimbabwe
Kazione Kulisewa
Affiliation:
Kamuzu University of Health Sciences , Malawi
*
Corresponding author: Melissa Ann Stockton; Email: melissaann.stockton@pennmedicine.upenn.edu
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Abstract

There are few evidence-based suicide prevention interventions tailored for adolescents living with HIV (ALWH) in sub-Saharan Africa. The safety planning intervention targets acute suicidal behavior through co-creation of actionable coping strategies for use at the onset of suicide-related distress. We utilized the Assessment-Decision-Adaptation-Production-Topical Experts-Integration-Training–Testing framework to adapt and integrate safety planning into an existing Friendship Bench + peer support model for depressed ALWH in Malawi. We conducted interviews with ALWH who reported suicidal ideation or behaviors, their caregivers, healthcare facility leadership and police officers, and focus group discussions with healthcare facility staff, community and religious leaders and teachers in Lilongwe. The study team produced adapted manuals, sought and integrated expert topical feedback, trained interventionists using a training-of-trainers model and theater tested the protocol. Formative data yielded insights into acceptability, feasibility, delivery, content and implementation of safety planning. The final safety planning + Friendship Bench + peer support program consists of one safety planning session, five problem-solving sessions with suicide risk assessment and six peer support sessions. We revised the written Safety Plan to account for limited emergency services, modified the protocol for engaging guardians, integrated suicide assessment into the problem-solving sessions and incorporated suicide prevention activities into the peer support sessions.

Information

Type
Research Article
Creative Commons
Creative Common License - CCCreative Common License - BY
This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0), which permits unrestricted re-use, distribution and reproduction, provided the original article is properly cited.
Copyright
© The Author(s), 2026. Published by Cambridge University Press
Figure 0

Table 1. Activities by ADAPT-ITT phaseTable 1. long description.

Figure 1

Table 2. Formative study participantsTable 2. long description.

Figure 2

Table 3. Phase 3 formative feedback and implications for adaptationTable 3. long description.

Figure 3

Table 4. Overview of intervention adaptationsTable 4. long description.

Figure 4

Figure 1. Adaptions to Written Safety Plan.Figure 1. long description.

Author comment: Integrating safety planning, problem-solving therapy and peer support for suicide prevention among adolescents living with HIV in Malawi: An application of the ADAPT-ITT adaptation framework — R0/PR1

Comments

21 August 2025

Submission of a manuscript for review, Cambridge Prisms: Global Mental Health

Dear Drs. Galea, Kosyluk, Onie, and Martinez-Ales,

I would be grateful if you would consider the following manuscript by Stockton et al. “Integrating Safety Planning, Problem-Solving Therapy, and Peer Support for Suicide Prevention among Adolescents Living with HIV in Malawi: An Application of the ADAPT-ITT Adaptation Framework” for publication in the “Self-harm and Suicide: A Global Priority” collection within Cambridge Prisms: Global Mental Health.

In this manuscript, we describe how we used the ADAPT-ITT framework to adapt the Safety Planning Intervention and generated a comprehensive suicide prevention program complete with Safety Planning, Friendship Bench problem-solving therapy, and peer support. Our application of ADAPT-ITT proved useful, and allowed for a discussion of lessons for adapting Safety Planning in low-resource settings as well as the challenges and successes we encountered using ADAPT-ITT to guide the process. If published, our manuscript will support the continued growth of suicide prevention research in the sub-Saharan region, and provide useful insights into the implementation of mental health programming for adolescents living with HIV. We believe that our manuscript is a good fit for the “Self-harm and Suicide: a Global Priority” collection.

All authors have approved the manuscript. We confirm that this manuscript has not been published elsewhere and is not under consideration by another journal. Should you have any queries, please do not hesitate to contact me via email.

On behalf of all authors, I look forward to hearing from you soon.

Yours sincerely,

Melissa Stockton, PhD

Assistant Professor

Psychiatry Department

Perelman School of Medicine

University of Pennsylvania

Review: Integrating safety planning, problem-solving therapy and peer support for suicide prevention among adolescents living with HIV in Malawi: An application of the ADAPT-ITT adaptation framework — R0/PR2

Conflict of interest statement

Reviewer declares none.

Comments

Suicide among adolescents is a global health crisis, is the second leading cause of death for adolescents and young adults,

occurs predominantly in low- and middle-income countries (LMICs)

The opening sentence highlights an important global concern; however, the phrasing could be improved for clarity and flow. I recommend rewording it to read more smoothly and to align with current WHO terminology. ‘’ Suicide among adolescents is a major global public health concern and remains the second leading cause of death among adolescents and young adults, with the majority of cases occurring in low- and middle-income countries (LMICs)

World Health Organization. Adolescent and young adult health [Fact sheet]. WHO; 26 Nov 2024. Available from: https://www.who.int/news-room/fact-sheets/detail/adolescents-health-risks-and-solutions

Gould M. Suicide and Suicide Attempts in Adolescents. Pediatrics. 2016;138(1):e20161420. doi:10.1542/peds.2016-142

In Malawi, the estimated past-year prevalence of thinking about suicide among adolescents is above

10%.(Shaikh et al. 2016) While data on suicidal ideation and behaviors (SIBs) in Malawi is sparse,(MacLean et al. 2018;

Malava 2018; Pengpid and Peltzer 2021) an estimated 18-26% of Malawian adolescents living with HIV (ALWH) are

affected by depression,(Kim et al. 2015a) an underlying risk factor for SIBs.(Kemigisha et al. 2019; Necho et al. 2021;

The paragraph presents important contextual data; however, the sentence structure and referencing need refinement for clarity and accuracy. The current version reads as a long, complex sentence with inconsistent citation formatting and an incomplete closing parenthesis. I recommend breaking it into shorter sentences and using consistent reference punctuation (e.g., “Shaikh et al., 2016; MacLean et al., 2018”). Additionally, it would strengthen the paragraph to clearly link depression to suicidal ideation and behaviors, since that connection is central to the argument. A suggested revision could be:

“In Malawi, the estimated past-year prevalence of suicidal thoughts among adolescents exceeds 10% (Shaikh et al., 2016). However, data on suicidal ideation and behaviors (SIBs) in the country remain sparse (MacLean et al., 2018; Malava, 2018; Pengpid & Peltzer, 2021). Among adolescents living with HIV (ALWH), an estimated 18–26% experience depression (Kim et al., 2015a), which is a well-established risk factor for suicidal ideation and behaviors (Kemigisha et al., 2019; Necho et al., 2021)

The Friendship Bench, a problem-solving therapy model for depression treatment increasingly used among adults inMalawi,(Bengtson et al. 2023b; Chibanda et al. 2011; Pence et al. 2024; Pierce 2012; Udedi et al. 2019) was recently

adapted and enhanced to meet the needs of ALWH.(Dao et al. 2025)

It is important that you double check your ethical tone and descriptions ‘’ Saying “used among adults” is correct but if the statement implies exclusively adults, you’d need to check what you mean by “adults” (e.g., 18+)

. Methods

Our multi-disciplinary team included both Malawian and US-based researchers, psychiatric specialists, and representatives from the Malawi Ministry of Health

consider clarifying the specific expertise or roles of each group (e.g., “Malawian and US-based researchers, including psychiatric specialists and Ministry of Health representatives”) to make the contribution of each partner clearer.

Glossary of Terms and Abbrreviations(Annex

Not sure about your word counts but i see value in uploading a table of the often used abbreviations

Our multi-disciplinary team included both Malawian and US-based researchers, psychiatric specialists, and

representatives from the Malawi Ministry of Health. Together, we employed the eight stages of the ADAPT-ITT

framework to adapt Safety Planning and develop the Safety Planning + Friendship Bench + Peer Support (SP+FB+PS)

protocol. (Table 1) We built on the existing youth-friendly FB+PS model, which had already been adapted for ALWH in

Malawi using ADAPT-ITT.(Dao et al. 2025) The existing FB+PS model included two protocolized manuals: one for the

psychosocial counsellor-delivered Friendship Bench problem-solving therapy sessions and one for the peer supporterdelivered peer support sessions. Our new adaptation efforts focused heavily on adapting the Safety Planning Intervention

and integrating suicide prevention activities into the existing FB+PS model.

Phase 1: Assessment

We assessed ALWH’s SIBs prevention and treatment needs through a literature review (as summarized in the

introduction) and through discussion of our team’s vast prior research experience on adolescent mental health and HIV

care in Malawi. We conducted additional formative research as part of Phase 3 & 4 (described below) that confirmed this

assessment.

The section presents a well-structured overview of the adaptation process and demonstrates a strong multidisciplinary collaboration. However, the use of the terms “peer support” and “psychosocial support” appears somewhat overlapping and may cause conceptual ambiguity. Since the Safety Planning intervention already contains psychosocial support components, it would be helpful if the authors could clarify what they specifically mean by “psychosocial support” in this context for example, what type or modality of support was provided, by whom, and how it differs from peer support within the integrated SP+FB+PS model.

We then conducted interviews with ALWH aged 13-19 who reported SIBs (n=10), their guardians or caregivers (n=9), and healthcare facility leadership (n=6) and focus group discussions with healthcare providers (HCPs) (n=3) recruited from three public health facilities in Lilongwe. (Table 2). ALWH were screened for SIBs using item 9 of the Patient Health Questionnaire-9 (PHQ-9) and Ask Suicide-Screening Questions (ASQ) Toolkit,(Horowitz et al. 2012; Mutumba et al. 2014; Thompson et al. 2025) and suicide risk was assessed with the Suicide Risk Assessment Protocol (SRAP).(Landrum et al. 2023) All ALWH (regardless of study enrolment) who reported SIBs received supportive counselling and follow-up from a nurse trained in suicide safety management. Of the 10 ALWH, nine allowed a caregiver to be interviewed. Caregivers were predominantly women, including five mothers, one father, two sisters, and one aunt. Healthcare facility leadership included nurses and clinicians in coordinator or leadership roles related to adolescent HIV care. HCPs included seven nurses, five clinicians, two HIV testing and counseling counselors, two treatment supporters, one laboratory technician and one clerk. Additionally, we conducted interviews with police officers (n=6) and focus group discussions with teachers (n=1) and community leaders (n=1), and religious leaders (n=2) from Lilongwe.

clarify recruitment and sampling logic – briefly explain why specific groups (e.g., police officers, teachers, and religious leaders) were included and how their perspectives contributed to the study’s objectives.

Distinguish between participant groups and data collection methods – for example, using separate sentences or subparagraphs for adolescents/caregivers, healthcare providers, and community stakeholders.

Simplify or tabulate participant characteristics – some information (e.g., caregiver composition, HCP roles) could be presented more clearly in Table 2 rather than in-text.

Ensure terminology consistency – it would be useful to specify whether all groups were interviewed or if some participated in focus groups only, as the mix of “interviews” and “FGDs” currently reads ambiguously

ADAPTATIONS

While the use of the ADAPT-ITT framework is commendable and demonstrates a strong application of adaptation science, the manuscript does not clearly articulate the cultural and linguistic adaptation processes undertaken. Cultural adaptation goes beyond procedural modification it requires consideration of language, idioms of distress, local beliefs about mental health and suicide, and the broader sociocultural context in which ALWH live.

I recommend that the authors elaborate on how the intervention was culturally and linguistically tailored for Malawian adolescents for instance, how key concepts were translated or localized, how cultural explanatory models of distress were integrated, and whether any steps were taken to ensure cultural validity (e.g., community consultations, pre-testing of translated tools).

RESULTS

The distinction between an acute suicide crisis and a recent suicidal episode or event needs clearer operational definitions. How did the authors determine thresholds for inclusion (e.g., what constitutes “less severe suicidal ideation”)?

It would be useful to explain whether the adapted “narrative assessment” maintained the original SPI’s therapeutic structure and risk monitoring components, or if it functioned primarily as an exploratory interview.

Review: Integrating safety planning, problem-solving therapy and peer support for suicide prevention among adolescents living with HIV in Malawi: An application of the ADAPT-ITT adaptation framework — R0/PR3

Conflict of interest statement

Reviewer declares none.

Comments

The authors are commended for a comprehensive adaptation of a suicide prevention plan for adolescents living with HIV. The manuscript is well written with methodological rigor following the ADAPT-ITT model.

A few minor comments below;

1. In the phase 1 assessment methodology, it should have a structured approach, i.e what areas were assessed, how were they ranked etc?

2. The methods section can start with the study setting, who the participants were before the overview.

3. In phase 5 and 6, Who were the external experts, how were they chosen? Was the Ministry of Health included for scaling up?

Recommendation: Integrating safety planning, problem-solving therapy and peer support for suicide prevention among adolescents living with HIV in Malawi: An application of the ADAPT-ITT adaptation framework — R0/PR4

Comments

Dear Dr. Stockton and Co-Authors,

We have received reviews for your manuscript, with both reviewers recommending minor revisions. If you can address the reviewer comments thoroughly, we would be happy to consider a revised manuscript. Thank you for considering the special issue on Self-harm and Suicide: A Global Priority as an outlet for your work.

Kristin Kosyluk

Guest Editor

Decision: Integrating safety planning, problem-solving therapy and peer support for suicide prevention among adolescents living with HIV in Malawi: An application of the ADAPT-ITT adaptation framework — R0/PR5

Comments

No accompanying comment.

Author comment: Integrating safety planning, problem-solving therapy and peer support for suicide prevention among adolescents living with HIV in Malawi: An application of the ADAPT-ITT adaptation framework — R1/PR6

Comments

Dear Editors,

We greatly appreciate your thoughtful reviews. We have responded to the comments as requested and made all changes to the manuscript in tracked changes. We’ve uploaded a response to reviewers document that includes a detailed write-up of our point-by-point responses.

Sincerely,

Authors

Recommendation: Integrating safety planning, problem-solving therapy and peer support for suicide prevention among adolescents living with HIV in Malawi: An application of the ADAPT-ITT adaptation framework — R1/PR7

Comments

Dear Dr. Stockton and Colleagues,

I have had a chance to review your revised manuscript and response to reviewer comments. You did a nice job addressing reviewer comments, and we are pleased to accept your manuscript for publication in the special issue. Editorial staff will work with you to address some formatting problems, specifically with regard to in-text citations. Thank you for your important work.

Best,

Kristin Kosyluk

Guest Editor

Decision: Integrating safety planning, problem-solving therapy and peer support for suicide prevention among adolescents living with HIV in Malawi: An application of the ADAPT-ITT adaptation framework — R1/PR8

Comments

No accompanying comment.