Skip to main content Accessibility help
×
Hostname: page-component-89b8bd64d-72crv Total loading time: 0 Render date: 2026-05-10T02:06:50.431Z Has data issue: false hasContentIssue false

Chapter 10 - Tubulointerstitial Diseases with Crystal and Pigment Deposits

from Section 3 - Tubulointerstitial Diseases

Published online by Cambridge University Press:  10 August 2023

By
Joris J. Roelofs  and
Tri Q. Nguyen
Edited by
Helen Liapis
Helen Liapis
Affiliation:
Ludwig Maximilian University, Nephrology Center, Munich, Adjunct Professor and Washington University St Louis, Department of Pathology and Immunology, Retired Professor
Get access

Summary

Tubulointerstitial diseases with crystal and pigment deposits are important histopathological disease entities that occur in pediatric patients and that are associated with acute and chronic kidney injury. Tubulointerstitial diseases with crystal deposits include oxalate nephropathy, nephrocalcinosis and 2,8-dihydroxyadenine (DHA) nephropathy. Tubulointerstitial diseases with pigment deposits include myoglobin cast nephropathy, hemoglobin cast nephropathy, red blood cell casts and bile cast nephropathy.

Although some of these tubulointerstitial diseases may show overlapping histopathological features, it is important to distinguish them as separate entities, since each of them is associated with distinct clinical symptoms, etiologies, therapies and prognosis.

Keywords

Oxalate nephropathynephrocalcinosisadenine phosphoribosyltransferase deficiencyDHA nephropathymyoglobin cast nephropathyhemoglobin cast nephropathyred blood cell castsbile cast nephropathypigment nephropathy

Information

Type
Chapter
Information
Pediatric Nephropathology & Childhood Kidney Tumors , pp. 197 - 212
Publisher: Cambridge University Press
Print publication year: 2023

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

Book purchase

Temporarily unavailable

References

Buysschaert, B., Aydin, S., Morelle, J., Gillion, V., Jadoul, M., Demoulin, N.. Etiologies, clinical features, and outcome of oxalate nephropathy. Kidney International Reports 2020; 5: 1503–9.CrossRefGoogle ScholarPubMed
Lumlertgul, N., Siribamrungwong, M., Jaber, B. L., Susantitaphong, P.. Secondary oxalate nephropathy: A systematic review. Kidney International Reports 2018; 3: 1363–72.CrossRefGoogle ScholarPubMed
Cochat, P., Rumsby, G.. Primary hyperoxaluria. New England Journal of Medicine 2013; 369: 649–58.Google Scholar
Lieske, J. C., Monico, C. G., Holmes, W. S., Bergstralh, E. J., Slezak, J. M., Rohlinger, A. L., et al. International registry for primary hyperoxaluria. American Journal of Nephrology 2005; 25: 290–6.CrossRefGoogle ScholarPubMed
Hopp, K., Cogal, A. G., Bergstralh, E. J., Seide, B. M., Olson, J. B., Meek, A. M., et al. Phenotype-genotype correlations and estimated carrier frequencies of primary hyperoxaluria. Journal of the American Society of Nephrology 2015; 26: 2559–70.CrossRefGoogle ScholarPubMed
Markowitz, G. S., Nasr, S. H., Klein, P., Anderson, H., Stack, J. I., Alterman, L., et al. Renal failure due to acute nephrocalcinosis following oral sodium phosphate bowel cleansing. Human Pathology 2004; 35: 675–84.CrossRefGoogle ScholarPubMed
Schell-Feith, E. A., Kist-van Holthe, J. E., van Zwieten, P. H. T., Zonderland, H. M., Holscher, H. C., Swinkels, D. W., et al. Preterm neonates with nephrocalcinosis: Natural course and renal function. Pediatric Nephrology 2003; 18: 1102–8.Google Scholar
Sikora, P., Roth, B., Kribs, A., Michalk, D. V., Hesse, A., Hoppe, B.. Hypocitraturia is one of the major risk factors for nephrocalcinosis in very low birth weight (VLBW) infants. Kidney International 2003; 63: 2194–9.CrossRefGoogle ScholarPubMed
Gimpel, C., Krause, A., Franck, P., Krueger, M., von Schnakenburg, C.. Exposure to furosemide as the strongest risk factor for nephrocalcinosis in preterm infants. Pediatrics International 2010; 52: 51–6.CrossRefGoogle ScholarPubMed
Harambat, J., Bollée, G., Daudon, M., Ceballos-Picot, I., Bensman, A.; APRT Study Group. Adenine phosphoribosyltransferase deficiency in children. Pediatric Nephrology 2012; 27: 571–9.CrossRefGoogle ScholarPubMed
Runolfsdottir, H. L., Palsson, R., Agustsdottir, I. M., Indridason, O. S., Edvardsson, V. O.. Long-term renal outcomes of APRT deficiency presenting in childhood. Pediatric Nephrology 2019; 34: 435–42.CrossRefGoogle ScholarPubMed
Gaut, J. P., Liapis, H., Acute kidney injury pathology and pathophysiology: A retrospective review. Clinical Kidney Journal 2020; 1–11.CrossRefGoogle Scholar
Najafian, B., Fogo, A. B., Lusco, M. A., Alpers, C. E.. AJKD Atlas of Renal Pathology: Myoglobin cast nephropathy. American Journal of Kidney Diseases 2017; 69: e7–e8.CrossRefGoogle ScholarPubMed
Liapis, H., Boils, C., Hennigar, R., Silva, F.. Myoglobin casts in renal biopsies: Immunohistochemistry and morphologic spectrum. Human Pathology 2016; 54: 25–30.CrossRefGoogle ScholarPubMed
Chen, C. Y., Lin, Y. R., Zhao, L. L., Yang, W. C., Chang, Y. J., Wu, K. H., et al. Clinical spectrum of rhabdomyolysis presented to pediatric emergency department. BMC Pediatrics 2013; 13: 134.Google Scholar
Dvanajscak, Z., Cossey, L. N., Larsen, C. P., A practical approach to the pathology of renal intratubular casts. Seminars in Diagnostic Pathology 2020; 37: 127–34.Google Scholar
Park, Y., Song, J. Y., Kim, S. Y., Kim, S. H.. Clinical characteristics of rhabdomyolysis in children: Single center experience. Childhood Kidney Diseases 2018; 22: 52–7.CrossRefGoogle Scholar
Dvanajscak, Z., Walker, P. D., Cossey, L. N., Messias, N. C., Boils, C. L., Kuperman, M. B., et al. Hemolysis-associated hemoglobin cast nephropathy results from a range of clinicopathologic disorders. Kidney International 2019; 96: 1400–7.CrossRefGoogle ScholarPubMed
González, I., Rais, R., Gaut, J. P., Dehner, L. P.. Evans syndrome complicated by intratubular hemoglobin cast nephropathy. Case Reports in Pediatrics 2017; 2017: 1–3.CrossRefGoogle ScholarPubMed
Brodsky, S. V., Satoskar, A., Chen, J., Nadasdy, G., Eagen, J. W., Hamirani, M., et al. Acute kidney injury during warfarin therapy associated with obstructive tubular red blood cell casts: A report of 9 cases. American Journal of Kidney Diseases 2009; 54: 1121–6.CrossRefGoogle Scholar
Mukherjee, T., Khan, I. D., Guha, R., Ganguly, T.. Cholemic nephrosis (bile cast nephropathy) with severe liver dysfunction. Medical Journal Armed Forces India 2019; 75: 216–18.Google Scholar
Lusco, M. A., Fogo, A. B., Najafian, B., Alpers, C. E.. AJKD Atlas of Renal Pathology: Bile nephrosis. American Journal of Kidney Diseases 2017; 69: e9.Google Scholar
Van Slambrouck, C. M., Salem, F., Meehan, S. M., Chang, A.. Bile cast nephropathy is a common pathologic finding for kidney injury associated with severe liver dysfunction. Kidney International 2013; 84: 192–7.CrossRefGoogle ScholarPubMed
Sood, V., Lal, B. B., Lata, S., Rastogi, A., Alam, S.. Cholemic or bile cast nephropathy in a child with liver failure. Journal of Clinical and Experimental Hepatology 2017; 7: 373–5.CrossRefGoogle ScholarPubMed
Bokor, J., Danics, K., Keller, E., Szollosi, Z.. Time-dependent changes in kidney histopathology in ethylene glycol poisoning. Medicine, Science and the Law 2018; 58: 257–60.Google Scholar
Snijders, M. L. H., Hesselink, D. A., Clahsen-van Groningen, M. C., Roodnat, J. I.. Oxalate deposition in renal allograft biopsies within 3 months after transplantation is associated with allograft dysfunction. PLOS ONE 2019; 14: e0214940.Google Scholar
Wiech, T., Hopfer, H., Gaspert, A., Banyai-Falger, S., Hausberg, M., Schroder, J., et al. Histopathological patterns of nephrocalcinosis: A phosphate type can be distinguished from a calcium type. Nephrology Dialysis Transplantation 2012; 27: 1122–31.CrossRefGoogle ScholarPubMed
Nasr, S. H., Sethi, S., Cornell, L. D., Milliner, D. S., Boelkins, M., Broviac, J., et al. Crystalline nephropathy due to 2,8-dihydroxyadeninuria: An under-recognized cause of irreversible renal failure. Nephrology Dialysis Transplantation 2010;25(6):1909–15.CrossRefGoogle ScholarPubMed
Uribe-Uribe, N., Herrera, G.. Ultrastructure of tubular casts. Ultrastructural Pathology 2006; 30: 159–66.CrossRefGoogle ScholarPubMed
Harambat, J., Fargue, S., Acquaviva, C., Gagnadoux, M.-F., Janssen, F., Liutkus, A., et al. Genotype–phenotype correlation in primary hyperoxaluria type 1: The p.Gly170Arg AGXT mutation is associated with a better outcome. Kidney International 2010: 77: 443–9.CrossRefGoogle ScholarPubMed
Harambat, J., van Stralen, K. J., Espinosa, L., Groothoff, J. W., Hulton, S.-A., Cerkauskiene, R., et al. Characteristics and outcomes of children with primary oxalosis requiring renal replacement therapy. Clinical Journal of the American Society of Nephrology 2012; 7: 458–65.Google Scholar
Porter, E.. Neonatal nephrocalcinosis: Long term follow up. Archives of Disease in Childhood – Fetal and Neonatal Edition 2006; 91: F333–F336.Google Scholar
Kist-van Holthe, J. E., van Zwieten, P. H. T., Schell-Feith, E. A., Zonderland, H. M., Holscher, H. C., Wolterbeek, R., et al. Is nephrocalcinosis in preterm neonates harmful for long-term blood pressure and renal function? Pediatrics 2007; 119: 468–75.Google Scholar
Runolfsdottir, H. L., Palsson, R., Agustsdottir, I. M. S., Indridason, O. S., Li, J., Dao, M., et al. Kidney transplant outcomes in patients with adenine phosphoribosyltransferase deficiency. Transplantation. 2020; 104: 2120–8.CrossRefGoogle ScholarPubMed
Brodsky, S. V., Nadasdy, T., Rovin, B. H., Satoskar, A. A., Nadasdy, G. M., Wu, H. M., et al. Warfarin-related nephropathy occurs in patients with and without chronic kidney disease and is associated with an increased mortality rate. Kidney International 2011; 80: 181–9.Google Scholar

Accessibility standard: Unknown

Why this information is here

This section outlines the accessibility features of this content - including support for screen readers, full keyboard navigation and high-contrast display options. This may not be relevant for you.

Accessibility Information

Accessibility compliance for the HTML of this chapter is currently unknown and may be updated in the future.

Save book to Kindle

To save this book to your Kindle, first ensure no-reply@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about saving to your Kindle.

Note you can select to save to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

Find out more about the Kindle Personal Document Service.

Available formats
×

Save book to Dropbox

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Dropbox.

Available formats
×

Save book to Google Drive

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Google Drive.

Available formats
×