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Evaluation of serum ischaemia-modified albumin levels in patients with Bell's palsy

Published online by Cambridge University Press:  22 August 2019

A E Göker ,
M H Alagöz ,
G Güntaş ,
A Baskadem Yilmazer ,
G Berkiten ,
B Tutar ,
ME Ekincioglu ,
M F Akgun ,
Y Uyar  and
E Ozdemir
A E Göker*
Affiliation:
Department of Otorhinolaryngology – Head and Neck Surgery, University of Health Sciences, Okmeydani Training and Research Hospital, Istanbul, Turkey
M H Alagöz
Affiliation:
Department of Biochemistry, University of Health Sciences, Okmeydani Training and Research Hospital, Istanbul, Turkey
G Güntaş
Affiliation:
School of Health, Kirklareli University, Kirklareli, Turkey
A Baskadem Yilmazer
Affiliation:
Department of Otorhinolaryngology – Head and Neck Surgery, University of Health Sciences, Okmeydani Training and Research Hospital, Istanbul, Turkey
G Berkiten
Affiliation:
Department of Otorhinolaryngology – Head and Neck Surgery, University of Health Sciences, Okmeydani Training and Research Hospital, Istanbul, Turkey
B Tutar
Affiliation:
Department of Otorhinolaryngology – Head and Neck Surgery, University of Health Sciences, Okmeydani Training and Research Hospital, Istanbul, Turkey
ME Ekincioglu
Affiliation:
Department of Otorhinolaryngology – Head and Neck Surgery, University of Health Sciences, Okmeydani Training and Research Hospital, Istanbul, Turkey
M F Akgun
Affiliation:
Department of Otorhinolaryngology – Head and Neck Surgery, University of Health Sciences, Okmeydani Training and Research Hospital, Istanbul, Turkey
Y Uyar
Affiliation:
Department of Otorhinolaryngology – Head and Neck Surgery, University of Health Sciences, Okmeydani Training and Research Hospital, Istanbul, Turkey
E Ozdemir
Affiliation:
Department of Otorhinolaryngology – Head and Neck Surgery, University of Health Sciences, Okmeydani Training and Research Hospital, Istanbul, Turkey
*
Author for correspondence: Dr Ayşe Enise Göker, Department of Otorhinolaryngology – Head and Neck Surgery, University of Health Sciences, Okmeydani Training and Research Hospital, Istanbul, Turkey E-mail: ayseenise@hotmail.com
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Abstract

Objective

This prospective study aimed to evaluate the relationship between serum ischaemia-modified albumin levels and Bell's palsy severity.

Methods

The study included 30 patients diagnosed with Bell's palsy and 30 healthy individuals. The patients were separated into three disease severity groups (grades 2, 3 and 4) according to House–Brackmann classification. Blood samples were collected from all participants and the results compared between groups.

Results

Significant differences in serum ischaemia-modified albumin were found between the study and control groups (p < 0.001); values were significantly higher in the study group than in the control group.

Conclusion

The significantly higher levels of serum ischaemia-modified albumin in the study group suggest that Bell's palsy pathogenesis is associated with oxidative stress.

Keywords

Facial NerveBell PalsyIschemia-Modified Albumin

Information

Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 133 , Issue 9 , September 2019 , pp. 810 - 813
Copyright
Copyright © JLO (1984) Limited, 2019 

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Footnotes

Dr A E Göker takes responsibility for the integrity of the content of the paper

References

1Peitersen, E. Bell's palsy: the spontaneous course of 2,500 peripheral facial nerve palsies of different etiologies. Acta Otolaryngol Suppl 2002;549:4–30Google Scholar
2Baugh, RF, Basura, GJ, Ishii, LE, Schwartz, SR, Drumheller, CM, Burkholder, R et al. Clinical practice guideline: Bell's palsy. Otolaryngol Head Neck Surg 2013;149(3 suppl):S1–27Google Scholar
3Greco, A, Gallo, A, Fusconi, M, Marinelli, C, Macri, GF, de Vincentiis, M. Bell's palsy and autoimmunity. Autoimmun Rev 2012;12:323–8Google Scholar
4Collinson, PO, Gaze, DC, Bainbridge, K, Morris, F, Morris, B, Price, A et al. Utility of admission cardiac troponin and “Ischemia Modified Albumin” measurements for rapid evaluation and rule out of suspected acute myocardial infarction in the emergency department. Emerg Med J 2006;23:256–61Google Scholar
5Cai, Z, Li, H, Wang, X, Niu, X, Ni, P, Zhang, W et al. Prognostic factors of Bell's palsy and Ramsay Hunt syndrome. Medicine (Baltimore) 2017;96:e5898Google Scholar
6Erdem, SS, Yerlikaya, FH, Çiçekler, H, Gül, M. Association between ischemia modified albumin, homocysteine, vitamin B(12) and folic acid in patients with severe sepsis. Clin Chem Lab Med 2012;50:1417–21Google Scholar
7Ellidag, HY, Eren, E, Aydin, O, Akgol, E, Yalcinkaya, S, Sezer, C et al. Ischemia modified albumin levels and oxidative stress in patients with bladder cancer. Asian Pac J Cancer Prev 2013;14:2759–63Google Scholar
8Güldoğan, CE, Kılıç, MÖ, Balamir, İ, Tez, M, Turhan, T. Correlation between ischemia-modified albumin and Ranson score in acute pancreatitis. Ulus Travma Acil Cerrahi Derg 2017;23:472–6Google Scholar
9Seshadri Reddy, V, Munikumar, M, Duggina, P, Varma, N. A diagnostic test accuracy meta-analysis of maternal serum ischemia-modified albumin for detection of preeclampsia. J Matern Fetal Neonatal Med 2019;32:2173–81Google Scholar
10Terzi, S, Dursun, E, Yılmaz, A, Özergin Coşkun, Z, Özgür, A, Çeliker, M et al. Oxidative stress and antioxidant status in patients with Bell's palsy. J Med Biochem 2017;36:18–22Google Scholar
11Murakami, S, Mizobuchi, M, Nakashiro, Y, Doi, T, Hato, N, Yanagihara, N. Bell palsy and herpes simplex virus: identification of viral DNA in endoneurial fluid and muscle. Ann Intern Med 1996;124(1 Pt 1):27–30Google Scholar
12Glass, GE, Tzafetta, K. Bell's palsy: a summary of current evidence and referral algorithm. Fam Pract 2014;31:631–42Google Scholar
13Iritani, H, Nishimura, Y, Minatogawa, T. Neurophysiology of ischemic facial nerve paralysis in an animal model. Acta Otolaryngol 1991;111:934–42Google Scholar
14Can, Ü, Yosunkaya, Ş. A new marker in ischemia: ischemia-modified albumin [in Turkish]. Kosuyolu Heart J 2017;20:148–52Google Scholar
15Gaze, DC. Ischemia modified albumin: a novel biomarker for the detection of cardiac ischemia. Drug Metab Pharmacokinet 2009;24:333–41Google Scholar
16Mastella, AK, Moresco, RN, da Silva, DB, Becker, AM, Duarte Marta, MMF, Giovelli, LL et al. Evaluation of ischemia-modified albumin in myocardial infarction and prostatic diseases. Biomed Pharmacother 2009;63:762–6Google Scholar
17Fidan, E, Mentese, A, Kavgaci, H, Orem, A, Fidan, S, Uzun, A et al. Increased ischemia-modified albumin levels in patients with gastric cancer. Neoplasma 2012;59:393–7Google Scholar
18Stachowicz-Stencel, T, Synakiewicz, A, Owczarzak, A, Sliwinska, A, Aleksandrowicz-Wrona, E, Lysiak-Szydowska, W et al. Ischemia-modified albumin as a biochemical marker in children with neuroblastoma and soft tissue sarcomas. J Clin Lab Anal 2011;25:255–8Google Scholar
19Babademez, MA, Gul, F, Kale, H, Muderris, T, Bayazit, Y, Ergin, M et al. Thiol/disulphide homeostasis in Bell's palsy as a novel pathogenetic marker. Clin Otolaryngol 2017;42:239–44Google Scholar
20Kang, TS, Vrabec, JT, Giddings, N, Terris, DJ. Facial nerve grading systems (1985–2002): beyond the House-Brackmann scale. Otol Neurotol 2002;23:767–71Google Scholar