Hostname: page-component-6766d58669-nf276 Total loading time: 0 Render date: 2026-05-20T12:23:32.483Z Has data issue: false hasContentIssue false
  • English
  • Français

Rhabdomyosarcoma of the trachea: first reported case treated with proton beam therapy

Published online by Cambridge University Press:  17 July 2012

R Exley ,
J M Bernstein ,
B Brennan  and
M P Rothera
R Exley
Affiliation:
Department of Head and Neck Surgical Oncology, Christie Hospital, Manchester, UK
J M Bernstein*
Affiliation:
Department of Head and Neck Surgical Oncology, Christie Hospital, Manchester, UK
B Brennan
Affiliation:
Department of Oncology, Royal Manchester Children's Hospital, UK
M P Rothera
Affiliation:
Department of Otolaryngology, Royal Manchester Children's Hospital, UK
*
Address for correspondence: Mr Jonathan M Bernstein, Clinical Research Fellow, Head and Neck Surgical Oncology, Radiotherapy Related Research, 2nd Floor, Christie Hospital, Wilmslow Road, Manchester M20 4BX, UK Fax: +44 (0)161 446 8111 E-mail: jonathan.bernstein@doctors.org.uk
Get access Rights & Permissions [Opens in a new window]

Abstract

Objective:

We report a case of rhabdomyosarcoma of the trachea in a 14-month-old child, and we present the first reported use of proton beam therapy for this tumour.

Case report:

A 14-month-old girl presented acutely with a seven-day history of biphasic stridor. Emergency endoscopic debulking of a posterior tracheal mass was undertaken. Histological examination revealed an embryonal rhabdomyosarcoma with anaplasia. Multimodality therapy with surgery and chemotherapy was administered in the UK, and proton beam therapy in the USA.

Conclusion:

Only three cases of rhabdomyosarcoma of the trachea have previously been reported in the world literature. This is the first reported case of treatment of this tumour with proton beam therapy. Compared with conventional radiotherapy, proton beam therapy may confer improved long-term outcome in children, with benefits including reduced irradiation of the spinal cord.

Keywords

RhabdomyosarcomaTracheaProton Beam TherapyPaediatric

Information

Type
Clinical Records
Information
The Journal of Laryngology & Otology , Volume 126 , Issue 9 , September 2012 , pp. 966 - 969
Copyright
Copyright © JLO (1984) Limited 2012

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

Article purchase

Temporarily unavailable

Footnotes

Presented at the 141st Semon Club Meeting, 2 June 2011, London, UK

References

1Months, SR, Raney, RB. Rhabdomyosarcoma of the head and neck in children: the experience at the Children's Hospital of Philadelphia. Med Pediatr Oncol 1986;14:288–92Google ScholarPubMed
2Vaccani, JP, Forte, V, de Jong, AL, Taylor, G. Ewing's sarcoma of the head and neck in children. Int J Pediatr Otorhinolaryngol 1999;48:209–16CrossRefGoogle ScholarPubMed
3Gradoni, P, Giordano, D, Oretti, G, Fantoni, M, Ferri, T. The role of surgery in children with head and neck rhabdomyosarcoma and Ewing's sarcoma. Surg Oncol 2010;19:e103–9CrossRefGoogle ScholarPubMed
4Donaldson, SS. The value of adjuvant chemotherapy in the management of sarcomas in children. Cancer 1985;55:2184–973.0.CO;2-N>CrossRefGoogle ScholarPubMed
5Baker, KS, Anderson, JR, Link, MP, Grier, HE, Qualman, SJ, Maurer, HM et al. Benefit of intensified therapy for patients with local or regional embryonal rhabdomyosarcoma: results from the Intergroup Rhabdomyosarcoma Study IV. J Clin Oncol 2000;18:2427–34CrossRefGoogle ScholarPubMed
6Dagher, R, Helman, L. Rhabdomyosarcoma: an overview. Oncologist 1999;4:34–44CrossRefGoogle ScholarPubMed
7Brown, RL, Azizkhan, RG. Pediatric head and neck lesions. Pediatr Clin North Am 1998;45:889–905CrossRefGoogle ScholarPubMed
8Weber, C. Investigation of hypertrophic tongue and comments on striated muscle fibres [in German]. Arch Pathol Anat 1854;7:115–21CrossRefGoogle Scholar
9Dodd-o, JM, Wieneke, KF, Rosman, PM. Laryngeal, rhabdomyosarcoma. Case report and literature review. Cancer 1987;59:1012–183.0.CO;2-A>CrossRefGoogle ScholarPubMed
10Hicks, J, Flaitz, C. Rhabdomyosarcoma of the head and neck in children. Oral Oncol 2002;38:450–9CrossRefGoogle ScholarPubMed
11Kedar, A, Cantrel, G, Rosen, G. Rhabdomyosarcoma of the trachea. J Laryngol Otol 1988;102:735–6CrossRefGoogle ScholarPubMed
12Larsson, S, Lepore, V, Cardillo, G, Seidal, T. Primary tracheal rhabdomyosarcoma. Case report. Scand J Thorac Cardiovasc Surg 1989;23:293–5CrossRefGoogle ScholarPubMed
13Ruszel, J, Prauer, HW, Bulinska, H, Kozlowski, J. A case of rhabdomyosarcoma of trachea in a 7-year-old child [in Polish]. Otolaryngol Pol 1993;47:270–3Google Scholar
14Newton, WA Jr, Gehan, EA, Webber, BL, Marsden, HB, van Unnik, AJ, Hamoudi, AB et al. Classification of rhabdomyosarcomas and related sarcomas. Pathologic aspects and proposal for a new classification – an Intergroup Rhabdomyosarcoma Study. Cancer 1995;76:1073–853.0.CO;2-L>CrossRefGoogle ScholarPubMed
15Kodet, R, Newton, WA Jr, Hamoudi, AB, Asmar, L, Jacobs, DL, Maurer, HM. Childhood rhabdomyosarcoma with anaplastic (pleomorphic) features. A report of the Intergroup Rhabdomyosarcoma Study. Am J Surg Pathol 1993;17:443–53Google ScholarPubMed
16Simon, JH, Paulino, AC, Smith, RB, Buatti, JM. Prognostic factors in head and neck rhabdomyosarcoma. Head Neck 2002;24:468–73CrossRefGoogle ScholarPubMed
17Crist, WM, Anderson, JR, Meza, JL, Fryer, C, Raney, RB, Ruymann, FB et al. Intergroup rhabdomyosarcoma study-IV: results for patients with nonmetastatic disease. J Clin Oncol 2001;19:3091–102CrossRefGoogle ScholarPubMed
18Levin, WP, Kooy, H, Loeffler, JS, DeLaney, TF. Proton beam therapy. Br J Cancer 2005;93:849–54CrossRefGoogle ScholarPubMed
19Miralbell, R, Lomax, A, Cella, L, Schneider, U. Potential reduction of the incidence of radiation-induced second cancers by using proton beams in the treatment of pediatric tumors. Int J Radiat Oncol Biol Phys 2002;54:824–9CrossRefGoogle ScholarPubMed