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Energy metabolism of cells in the macula flava of the newborn vocal fold from the aspect of mitochondrial microstructure

Published online by Cambridge University Press:  25 June 2021

K Sato ,
S Chitose ,
K Sato ,
F Sato ,
T Ono  and
H Umeno
K Sato*
Affiliation:
Department of Otolaryngology – Head and Neck Surgery, Kurume University School of Medicine, Kurume, Japan
S Chitose
Affiliation:
Department of Otolaryngology – Head and Neck Surgery, Kurume University School of Medicine, Kurume, Japan
K Sato
Affiliation:
Department of Otolaryngology – Head and Neck Surgery, Kurume University School of Medicine, Kurume, Japan
F Sato
Affiliation:
Department of Otolaryngology – Head and Neck Surgery, Kurume University School of Medicine, Kurume, Japan
T Ono
Affiliation:
Department of Otolaryngology – Head and Neck Surgery, Kurume University School of Medicine, Kurume, Japan
H Umeno
Affiliation:
Department of Otolaryngology – Head and Neck Surgery, Kurume University School of Medicine, Kurume, Japan
*
Author for correspondence: Dr Kiminori Sato, Department of Otolaryngology – Head and Neck Surgery, Kurume University School of Medicine, 67 Asahi-machi, Kurume830-0011, Japan E-mail: kimisato@oct-net.ne.jp Fax: +81 942 371 200
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Abstract

Objective

Cells in the vocal fold of maculae flavae are likely to be tissue stem cells. Energy metabolism of the cells in newborn maculae flavae was investigated from the aspect of mitochondrial microstructure.

Method

Five normal newborn vocal folds were investigated under transmission electron microscopy.

Results

Mitochondria consisted of a double membrane bounded body containing matrices and a system of cristae. However, these membranes were ambiguous. In each mitochondrion, the lamellar cristae were sparse. Intercristal space was occupied by a mitochondrial matrix. Some mitochondria had fused to lipid droplets and rough endoplasmic reticulum, and both the mitochondrial outer and inner membranes had incarcerated and disappeared.

Conclusion

The features of the mitochondria of the cells in the newborn maculae flavae showed that their metabolic activity and oxidative phosphorylation were low. The metabolism of the cells in the newborn maculae flavae seems to be favourable to maintain the stemness and undifferentiation of the cells.

Keywords

Energy MetabolismMitochondriaStem CellsVocal CordsLarynxInfantNewborn
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 135 , Issue 9 , September 2021 , pp. 779 - 784
Copyright
Copyright © The Author(s), 2021. Published by Cambridge University Press

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Footnotes

Dr K Sato takes responsibility for the integrity of the content of the paper

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