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True carcinosarcoma of the larynx

Published online by Cambridge University Press:  07 December 2012

M Zhang ,
L-M Zhao ,
X-M Li ,
L Zhou ,
L Lin  and
S-Y Wang
M Zhang
Affiliation:
Department of Otolaryngology, Eye, Ear, Nose and Throat Hospital, Fudan University, Shanghai, PR China
L-M Zhao
Affiliation:
Department of Otolaryngology, Children's Hospital, Shanghai Jiaotong University, Shanghai, PR China
X-M Li*
Affiliation:
Department of Otolaryngology, Eye, Ear, Nose and Throat Hospital, Fudan University, Shanghai, PR China
L Zhou
Affiliation:
Department of Otolaryngology, Eye, Ear, Nose and Throat Hospital, Fudan University, Shanghai, PR China
L Lin
Affiliation:
Department of Pathology, Eye, Ear, Nose and Throat Hospital, Fudan University, Shanghai, PR China
S-Y Wang
Affiliation:
Department of Pathology, Eye, Ear, Nose and Throat Hospital, Fudan University, Shanghai, PR China
*
Address for correspondence: Dr Xiao-ming Li, Department of Otolaryngology, Eye, Ear, Nose and Throat Hospital, Fudan University, 83 Fen Yang Road, Shanghai, 200031, PR China Fax: +86 21 64377151 E-mail: ent_zhm@126.com
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Abstract

Objective:

To explore the diagnosis and treatment of carcinosarcoma of the larynx.

Methods:

Clinical information, including presentation, pathology, treatment and outcome, was obtained from a review of patient charts.

Results:

Seven male patients were confirmed pathologically to have had carcinosarcoma between 2003 and 2009 in our hospital. All patients underwent surgery: four total laryngectomies, two vertical partial laryngectomies, and one supracricoid partial laryngectomy-cricohyoidopexy. The mean follow up was 40.6 months. At the time of writing, six patients were alive and being followed; two of these suffered regional metastasis to the cervical lymphatic nodes and underwent radical neck dissection. One patient died of multiple distant metastases 60 months post-operatively.

Conclusion:

Carcinosarcoma of the larynx describes a biphasic tumour showing both carcinomatous and sarcomatous differentiation. It is extraordinarily rare and prone to metastasise to the cervical lymph nodes. Complete surgical resection of laryngeal primary lesions with wide margins and suitable neck dissection of cervical nodes is reasonable therapy.

Keywords

Laryngeal NeoplasmsCarcinosarcomaDiagnosisClinical ProtocolsPathology
Type
Clinical Records
Information
The Journal of Laryngology & Otology , Volume 127 , Issue 1 , January 2013 , pp. 100 - 103
Copyright
Copyright © JLO (1984) Limited 2012

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