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Extracellular vesicles revolutionizing animal reproductive biotechnology: a review
Published online by Cambridge University Press: 15 December 2025
Abstract
Extracellular vesicles (EVs) are implicated in various functions within the complex mechanisms of intercellular communication. There are several subpopulations of EVs, including apoptotic bodies, microvesicles and exosomes. These nanovesicles are capable of transferring functional proteins and genetic information to alter the phenotype and function of recipient cells. In animal reproduction, numerous studies have demonstrated that EVs are actively involved in the regulation of different physiological events, modulating a variety of processes such as follicular development, spermatogenesis, oocyte maturation, fertilization and embryo development, with results indicating improved gamete quality, embryo development and cryotolerance. Additionally, EVs show therapeutic potential in restoring reproductive function and supporting maternal-embryonic communication in both domestic and wild species. Therefore, the present review aimed to describe the main studies conducted using EVs in the field of animal reproduction, highlighting their biological relevance, experimental applications and future prospects for clinical implementation in assisted reproductive technologies.
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References
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