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Nutritional effects on foetal growth

Published online by Cambridge University Press:  18 August 2016

J. J. Robinson ,
K. D. Sinclair  and
T. G. McEvoy
J. J. Robinson
Affiliation:
Animal Biology Division, Scottish Agricultural College, Ferguson Building, Craibstone Estate, Bucksburn, Aberdeen AB21 9YA
K. D. Sinclair
Affiliation:
Animal Biology Division, Scottish Agricultural College, Ferguson Building, Craibstone Estate, Bucksburn, Aberdeen AB21 9YA
T. G. McEvoy
Affiliation:
Animal Biology Division, Scottish Agricultural College, Ferguson Building, Craibstone Estate, Bucksburn, Aberdeen AB21 9YA
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Abstract

The emphasis in nutritional studies on foetal growth has now moved from the last trimester of pregnancy, when most of the increase in foetal size takes place, to earlier stages of pregnancy that coincide with foetal organogenesis and tissue hyperplasia. At these stages absolute nutrient requirements for foetal growth are small but foetal metabolic activity and specific growth rate are high. It is thus a time when nutrient supply interacts with maternal factors such as size, body condition and degree of maturity to influence placental growth and set the subsequent pattern of nutrient partitioning between the gravid uterus and maternal body.

Throughout pregnancy the maternal diet controls foetal growth both directly, by supplying essential nutrients and indirectly, by altering the expression of the maternal and foetal endocrine mechanisms that regulate the uptake and utilization of these nutrients by the conceptus. Nutritional effects on the endocrine environment of the embryo during the early stages of cell division can alter the subsequent foetal growth trajectory and size at birth; so too can current in vitro systems for oocyte maturation and embryo culture up to the blastocyst stage. There is increasing evidence that subtle alterations in nutrient supply during critical periods of embryonic and foetal life can impart a legacy of growth and developmental changes that affect neonatal survival and adult performance. Identifying the specific nutrients that programme these effects and understanding their mode of action should provide new management strategies for ensuring that nutritional regimens from oocyte to newborn are such that they maximize neonatal viability and enable animals to express their true genetic potential for production.

Keywords

foetal growthnutrition

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Type
Research Article
Information
Animal Science , Volume 68 , Issue 2 , March 1999 , pp. 315 - 331
Copyright
Copyright © British Society of Animal Science 1999

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