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A comparative histopathological study of vocal fold polyps in smokers versus non-smokers

Published online by Cambridge University Press:  19 March 2015

K G Effat  and
M Milad
K G Effat*
Affiliation:
Department of Otolaryngology, El-Sahel Teaching Hospital, Cairo, Egypt
M Milad
Affiliation:
Department of Pathology, Cairo University Hospital, Egypt
*
Address for correspondence:Dr K G Effat, 6 Falaky Square, Cairo, Egypt E-mail: kamaleffat@hotmail.com
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Abstract

Background:

A large proportion of patients with vocal fold polyps are cigarette smokers. However, prior to this report no comparative study of polyp histopathology in smokers versus non-smokers had been performed.

Methods:

A prospective histopathological study of vocal fold polyps excised from 29 patients was undertaken. This comprised a comparative analysis of polyp histopathology in smokers versus non-smokers and a review of the pertinent literature.

Results:

Vocal fold polyps were larger in smokers than in non-smokers. Histopathological features significantly associated with the polyps of smokers versus those of non-smokers were increased keratinisation, dysplasia, a basement membrane thinning and hyaline degeneration.

Conclusion:

Cigarette smoke has an injurious effect on vocal fold polyp epithelium and leads to increased hyaline degeneration in polyps.

Keywords

Vocal foldPolypsSmokingHistopathology

Information

Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 129 , Issue 5 , May 2015 , pp. 484 - 488
Copyright
Copyright © JLO (1984) Limited 2015 

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