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Resection of secondary pulmonary malignancies in head and neck cancer patients

Published online by Cambridge University Press:  02 June 2010

T W Geurts ,
H M Klomp ,
S A Burgers ,
H van Tinteren ,
B Y Roukema  and
A J M Balm
T W Geurts
Affiliation:
Department of Head Neck Oncology and Surgery, The Netherlands Cancer Institute – Antoni van Leeuwenhoek Hospital, The Netherlands Department of ORL, Deventer Hospital, The Netherlands
H M Klomp
Affiliation:
Department of Thoracic Oncology and Surgery, The Netherlands Cancer Institute – Antoni van Leeuwenhoek Hospital, The Netherlands
S A Burgers
Affiliation:
Department of Thoracic Oncology and Surgery, The Netherlands Cancer Institute – Antoni van Leeuwenhoek Hospital, The Netherlands
H van Tinteren
Affiliation:
Department of Medical Statistics, The Netherlands Cancer Institute – Antoni van Leeuwenhoek Hospital, The Netherlands
B Y Roukema
Affiliation:
Department of Head Neck Oncology and Surgery, The Netherlands Cancer Institute – Antoni van Leeuwenhoek Hospital, The Netherlands
A J M Balm*
Affiliation:
Department of Head Neck Oncology and Surgery, The Netherlands Cancer Institute – Antoni van Leeuwenhoek Hospital, The Netherlands Department of ORL, Academic Medical Center, Amsterdam, The Netherlands
*
Address for correspondence: Prof. Dr A J M Balm, Department of Head and Oncology and Surgery, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands. Fax: +31 20 5122554 E-mail: a.balm@nki.nl
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Abstract

Background:

This study aimed to evaluate a single institute's experience with resection of metachronous pulmonary malignancy in patients treated for squamous cell carcinoma of the head and neck.

Methods:

Sixty-three consecutive patients treated curatively for head and neck squamous cell carcinoma underwent surgical resection of malignant lung lesions. Survival was estimated and potential prognostic factors investigated.

Results:

The median overall survival for the total group was 22.2 months. Fifty-one patients (81 per cent) had one lung lesion, while the remainder had multiple lesions (range, two to seven). In the 63 patients, 35 lobectomies, 4 pneumonectomies and 24 wedge resections were performed. For patients with pulmonary squamous cell carcinoma (n = 52), the three-year survival rate was 35 per cent (95 per cent confidence interval, 22–48); for patients with resected adenocarcinoma (n = 10), it was 50 per cent (95 per cent confidence interval, 18–75). The overall five-year survival rate was 30 per cent (95 per cent confidence interval, 19–42).

Conclusion:

In patients treated curatively for head and neck squamous cell carcinoma, resection of secondary pulmonary cancer is associated with favourable long term overall survival, especially for patients with adenocarcinoma lesions.

Keywords

Head And Neck NeoplasmsTumour MetastasisLungAdenocarcinoma

Information

Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 124 , Issue 12 , December 2010 , pp. 1278 - 1283
Copyright
Copyright © JLO (1984) Limited 2010

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References

1Winter, H, Meimarakis, G, Hoffmann, G, Hummel, M, Rüttinger, D, Zilbauer, A et al. Does surgical resection of pulmonary metastases of head and neck cancer improve survival? Ann Surg Oncol 2008;15:2915–26Google Scholar
2Ferlito, A, Shaha, AR, Silver, CE, Rinaldo, A, Mondin, V. Incidence and sites of distant metastases from head and neck cancer. ORL J Otorhinolaryngol Relat Spec 2001;63:202–7CrossRefGoogle ScholarPubMed
3Leon, X, Quer, M, Diez, S, Orus, C, Lopez-Pousa, A, Burgues, J. Second neoplasm in patients with head and neck cancer. Head Neck 1999;21:204–10Google Scholar
4Finley, RK 3rd, Verazin, GT, Driscoll, DL, Blumenson, LE, Takita, H, Bakamjian, V et al. Results of surgical resection of pulmonary metastases of squamous cell carcinoma of the head and neck. Am J Surg 1992;164:594–8CrossRefGoogle ScholarPubMed
5Mazer, TM, Robbins, KT, McMurtrey, MJ, Byers, RM. Resection of pulmonary metastases from squamous carcinoma of the head and neck. Am J Surg 1988;156:238–42CrossRefGoogle ScholarPubMed
6Leong, PP, Rezai, B, Koch, WM, Reed, A, Eisele, D, Lee, DJ et al. Distinguishing second primary tumors from lung metastases in patients with head and neck squamous cell carcinoma. J Natl Cancer Inst 1998;90:972–7CrossRefGoogle ScholarPubMed
7Geurts, TW, Nederlof, PM, van den Brekel, MW, van't Veer, LJ, de Jong, D, Hart, AA et al. Pulmonary squamous cell carcinoma following head and neck squamous cell carcinoma: metastasis or second primary? Clin Cancer Res 2005;11:6608–14Google Scholar
8Geurts, TW, van Velthuysen, ML, Broekman, F, van Huysduynen, TH, van den Brekel, MW, van Zandwijk, N et al. Differential diagnosis of pulmonary carcinoma following head and neck cancer by genetic analysis. Clin Cancer Res 2009;15:980–5CrossRefGoogle ScholarPubMed
9Wedman, J, Balm, AJ, Hart, AA, Loftus, BM, Hilgers, FJ, Gregor, RT et al. Value of resection of pulmonary metastases in head and neck cancer patients. Head Neck 1996;18:311–163.0.CO;2-0>CrossRefGoogle ScholarPubMed
10Liu, D, Labow, DM, Dang, N, Martini, N, Bains, M, Burt, M et al. Pulmonary metastasectomy for head and neck cancers. Ann Surg Oncol 1999;6:572–8CrossRefGoogle ScholarPubMed
11Nibu, K, Nakagawa, K, Kamata, S, Kawabata, K, Nakamizo, M, Nigauri, T et al. Surgical treatment for pulmonary metastases of squamous cell carcinoma of the head and neck. Am J Otolaryngol 1997;18:391–5CrossRefGoogle ScholarPubMed
12Black, WC. Computed tomography screening for lung cancer. Review of screening principles and update on current status. Cancer 2007;110:2370–84CrossRefGoogle ScholarPubMed
13Ritoe, SC, Krabbe, PF, Jansen, MM, Festen, J, Joosten, FB, Kaanders, JH et al. Screening for second primary lung cancer after treatment of laryngeal cancer. Laryngoscope 2002;112:2002–8CrossRefGoogle ScholarPubMed
14Buwalda, J, Zuur, CL, Lubsen, H, Tijssen, JG, Koole, R, Hordijk, GJ. Annual chest X-ray in patients after treatment for laryngeal or oral cancer: only a limited number of second primary lung cancers detected [in Dutch]. Ned Tijdschr Geneeskd 1999;143:1517–22Google ScholarPubMed
15de Visscher, AV, Manni, JJ. Routine long-term follow-up in patients treated with curative intent for squamous cell carcinoma of the larynx, pharynx, and oral cavity. Does it make sense? Arch Otolaryngol Head Neck Surg 1994;120:934–9Google Scholar
16Cooney, TR, Poulsen, MG. Is routine follow-up useful after combined-modality therapy for advanced head and neck cancer? Arch Otolaryngol Head Neck Surg 1999;125:379–82CrossRefGoogle ScholarPubMed
17Rubin, P, Green, J. Solitary Metastases. Springfield, Illinois: Charles C Thomas, 1968Google Scholar
18Rubin, P, Brasacchio, R, Katz, A. Solitary metastases: illusion versus reality. Seminars in Radiation Oncology 2006;16:120–30CrossRefGoogle ScholarPubMed
19Douglas, WG, Rigual, NR, Loree, TR, Wiseman, SM, Al-Rawi, S, Hicks, WL Jr.Current concepts in the management of a second malignancy of the lung in patients with head and neck cancer. Curr Opin Otolaryngol Head Neck Surg 2003;11:85–8Google Scholar
20de Bree, R, Deurloo, EE, Snow, GB, Leemans, CR. Screening for distant metastases in patients with head and neck cancer. Laryngoscope 2000;110:397–401CrossRefGoogle ScholarPubMed
21Hsu, YB, Chu, PY, Liu, JC, Lan, MC, Chang, SY, Tsai, TL et al. Role of chest computed tomography in head and neck cancer. Arch Otolaryngol Head Neck Surg 2008;134:1050–4CrossRefGoogle ScholarPubMed
22Porrello, C, Alifano, M, Forti Parri, SN, Sanna, S, Lacava, N, Corneli, G et al. Surgical treatment of stage I lung cancer. Results and prognostic factors. J Cardiovasc Surg 2002;43:723–7Google Scholar
23Suzuki, K, Nagai, K, Yoshida, J, Moriyama, E, Nishimura, M, Takahashi, K et al. Prognostic factors in clinical stage I non-small cell lung cancer. Ann Thorac Surg 1999;67:927–32Google Scholar
24Antakli, T, Schaefer, RF, Rutherford, JE, Read, RC. Second primary lung cancer. Ann Thorac Surg 1995;59:863–6Google Scholar
25Wada, H, Fukuse, T, Hitomi, S. Long-term survival of surgical cases of lung cancer. Lung Cancer 1995;13:269–74Google Scholar
26Rossing, TH, Rossing, RG. Survival in lung cancer. An analysis of the effects of age, sex, resectability, and histopathologic type. Am Rev Respir Dis 1982;126:771–7Google ScholarPubMed
27Ichinose, Y, Yano, T, Asoh, H, Yokoyama, H, Yoshino, I, Katsuda, Y. Prognostic factors obtained by a pathologic examination in completely resected non-small-cell lung cancer. An analysis in each pathologic stage. J Thorac Cardiovasc Surg 1995;110:601–5Google Scholar
28Harpole, DH Jr, Herndon, JE 2nd, Young, WG Jr, Wolfe, WG, Sabiston, DC Jr.Stage I nonsmall cell lung cancer. A multivariate analysis of treatment methods and patterns of recurrence. Cancer 1995;76:787–963.0.CO;2-Q>CrossRefGoogle Scholar
29Martini, N, Bains, MS, Burt, ME, Zakowski, MF, McCormack, P, Rusch, VW et al. Incidence of local recurrence and second primary tumors in resected stage I lung cancer. J Thorac Cardiovasc Surg 1995;109:120–9Google Scholar
30Ajisaka, H. Multiple repeat metastasectomies for recurrences of colorectal cancer. Dig Surg 2008;25:98–102CrossRefGoogle ScholarPubMed
31Pastorino, U, Muscolino, M, Valente, S, Andreani, S, Tavecchio, L, Infante, M et al. The International Registry of Lung Metastases. Long-term results of lung metastasectomy: prognostic analyses based on 5206 cases. J Thorac Cardiovasc Surg 1997;113:37–49Google Scholar
32Huang, J, Behrens, C, Wistuba, I, Gazdar, AF, Jagirdar, J. Molecular analysis of synchronous and metachronous tumors of the lung: impact on management and prognosis. Ann Diagn Pathol 2001;5:321–9Google Scholar
33Hiroshima, K, Toyozaki, T, Kohno, H, Ohwada, H, Fujisawa, T. Synchronous and metachronous lung carcinomas: molecular evidence for multicentricity. Pathol Int 1998;48:869–76CrossRefGoogle ScholarPubMed
34Geurts, TW, Balm, AJ, van Velthuysen, ML, van Tinteren, H, Burgers, JA, van Zandwijk, N et al. Survival after surgical resection of pulmonary metastases and second primary squamous cell lung carcinomas in head and neck cancer. Head Neck 2009;31:220–6Google Scholar
35Screening for Lung Cancer. In: http://www.ahrq.gov/clinic/uspstf/uspslung.htm [February 2010]Google Scholar
36Kennedy, T, McWilliams, A, Edell, E, Sutedja, T, Downie, G, Yung, R et al. Bronchial intraepithelial neoplasia/early central airways lung cancer. ACCP evidence based clinical practice guidelines. Chest 2007;132(Suppl 3):221–33SGoogle Scholar
37Edell, E, Lam, S, Pass, H, Miller, YE, Sutedja, T, Kennedy, T et al. Detection and localization of intraepithelial neoplasia and invasive carcinoma using fluorescence-reflectance bronchoscopy: an international multicenter trial. J Thorac Oncol 2009;4:49–54CrossRefGoogle Scholar
38Sutedja, TG, Codrington, H, Risse, EK, Breuer, RH, van Mourik, JC, Golding, RP et al. Autofluorescence bronchoscopy improves staging of radiographically occult lung cancer and has an impact on therapeutic strategy. Chest 2001;120:1327–32Google Scholar
39Pastorino, U, Bellomi, M, Landoni, C, De Fiori, E, Arnaldi, P, Picchio, M et al. Early lung-cancer detection with spiral CT and positron emission tomography in heavy smokers: 2-year results. Lancet 2003;362:593–7Google Scholar
40Dragonieri, S, Annema, JT, Schot, R, van der Schee, MP, Spanevello, A, Carratú, P, Resta, O, Rabe, KF, Sterk, PJ.An electronic nose in the discrimination of patients with non-small cell lung cancer and COPD. Lung Cancer 2009;64:166–70Google Scholar
41Younes, RN, Gross, JL, Silva, JF, Fernandez, JA, Kowalski, LP. Surgical treatment of lung metastases of head and neck tumors. Am J Surg 1997;174:499–502Google Scholar
42Sercarz, J, Ellison, D, Holmes, EC, Calcaterra, TC. Isolated pulmonary nodules in head and neck cancer patients. Ann Otol Rhinol Laryngol 1989;98:113–18Google Scholar
43Mountain, CF, McMurtrey, MJ, Hermes, KE. Surgery for pulmonary metastasis: a 20-year experience. Ann Thorac Surg 1984;38:323–30Google Scholar