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Molecular differences in the nasal microenvironment of chronic rhinosinusitis with nasal polyposis: a systematic review

Published online by Cambridge University Press:  30 July 2025

Maria Riga Open the ORCID record for Maria Riga [Opens in a new window] ,
Rizam Alghamdi ,
Moath Alfaleh  and
Omar Alanzi
Maria Riga*
Affiliation:
Department of Otorhinolaryngology Head & Neck Surgery, Dammam Health Network, Dammam, Kingdom of Saudi Arabia
Rizam Alghamdi
Affiliation:
Department of Otorhinolaryngology Head & Neck Surgery, Dammam Health Network, Dammam, Kingdom of Saudi Arabia
Moath Alfaleh
Affiliation:
Department of Otorhinolaryngology Head & Neck Surgery, Dammam Health Network, Dammam, Kingdom of Saudi Arabia
Omar Alanzi
Affiliation:
Department of Otorhinolaryngology Head & Neck Surgery, Dammam Health Network, Dammam, Kingdom of Saudi Arabia
*
Corresponding author: Maria Riga; Email: mariariga@hotmail.com
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Abstract

Objectives

The present review aims at an insight into the pathophysiology of chronic rhinosinusitis with nasal polyposis through the combination of three tissue sources: (1) nasal polyp, (2) neighboring non-polypoid mucosa (MS) and (3) healthy controls.

Methods

The primary outcomes included three lists of molecules (1) those significantly different between nasal polyp, neighboring non-polypoid mucosa and controls (2) those up/downregulated in nasal polyp, but comparable between MS and controls and (3) those comparable between nasal polyp and neighboring non-polypoid mucosa, but different between NP and controls.

Results

Ten studies investigating a large variety of 68 molecules presented comparisons between nasal polyp and neighboring non-polypoid mucosa in endotype-specified populations. Comparisons between nasal polyp and neighboring non-polypoid mucosa are approached separately for eosinophilic/non-eosinophilic chronic rhinosinusitis with nasal polyposis . The small number of studies prohibits a meta-analysis.

Conclusion

Inclusion of neighboring non-polypoid mucosa in future studies may provide a bias-free list of the molecules that contribute to the actual pathogenesis and preservation of nasal polyps within the chronic rhinosinusitis inflammatory environment.

Keywords

chronic rhinosinusitiseosinophilicnasal polyposisnon-polypoid nasal mucosapathophysiology

Information

Type
Review Article
Information
The Journal of Laryngology & Otology , Volume 139 , Issue 11 , November 2025 , pp. 1015 - 1020
Copyright
© The Author(s), 2025. Published by Cambridge University Press on behalf of J.L.O. (1984) LIMITED.

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Footnotes

Maria Riga takes responsibility for the integrity of the content of the paper

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