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Post-Treatment Problems: What Can We Say about the Effect of a Treatment among Sub-Groups Who (Would) Respond in Some Way?

Published online by Cambridge University Press:  02 June 2026

Chad Hazlett
Affiliation:
Political Science, Statistics & Data Science, UCLA, Los Angeles, USA
Nina McMurry*
Affiliation:
Political Science, Vanderbilt University, Nashville, USA
Tanvi Shinkre
Affiliation:
Statistics & Data Science, UCLA, Los Angeles, USA
*
Corresponding author: Nina McMurry; Email: nina.mcmurry@vanderbilt.edu
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Abstract

Investigators are often interested in how a treatment affects an outcome for units responding to treatment in a certain way. We may wish to know the effect among units that, for example, meaningfully implemented an intervention, passed an attention check or demonstrated some important mechanistic response. Simply conditioning on the observed value of the post-treatment variable introduces problematic biases. Further, the identification assumptions required by several existing strategies are often indefensible. We propose the treatment reactive average causal effect (TRACE), which we define as the total effect of treatment in the group that, if treated, would realize a particular value of the relevant post-treatment variable. By reasoning about the effect among the “non-reactive” group, we can identify and estimate the range of plausible values for the TRACE. We demonstrate the use of this approach with three examples: (i) learning the effect of police-perceived race on police violence during traffic stops, a case where point identification may be possible; (ii) estimating effects of a community policing intervention in Liberia, in communities that meaningfully implemented it; and (iii) studying how in-person canvassing affects support for transgender rights, among participants for whom the intervention would result in more positive feelings toward transgender people.

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Article
Creative Commons
Creative Common License - CCCreative Common License - BY
This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (https://creativecommons.org/licenses/by/4.0), which permits unrestricted re-use, distribution and reproduction, provided the original article is properly cited.
Copyright
© The Author(s), 2026. Published by Cambridge University Press on behalf of The Society for Political Methodology
Figure 0

Figure 1 Causal structure of concern. A treatment (D), which is unconfounded with the outcome of interest (Y) may affect M in some sub-group. While some confounders of M and Y may be measured (X), we cannot rule out the presence of unobserved common causes of M and Y (U).

Figure 1

Table 1 Comparison of different estimands for settings in which post-treatment variables are relevantTable 1 long description.

Figure 2

Figure 2 Estimated TRACE of community policing intervention on reported mob violence, among communities for which the intervention would have produced a successful Community Watch Forum (implementing types), across postulated values of the treatment effect among non-implementing types (TRACE(0)). Line segments represent 95% confidence intervals. The number on the far right represents the “naive” ITT estimate, assuming constant treatment effects across strata of M. The gray shaded region represents the intersection of the no-assumption bounds and the range of estimates assuming a value for TRACE(0) less than or equal to the value of the TRACE, in the same direction. The green dots show the point estimates of the no assumption bounds, and corresponding 95% confidence intervals obtained by bootstrap. The pink bounds represent the MT bounds described in Section 3.7, and the pink crosshatch shows the intersection of the MT bounds with the assumptions on TRACE(0). All models include police zone (block) fixed effects and baseline levels of reported mob violence, averaged at the community-level, as a covariate.Figure 2 long description.

Figure 3

Figure 3 Estimated TRACE of community policing intervention on reported incidents of crime among implementing type communities, across postulated values of the treatment effect among non-implementing type communities (TRACE(0)), using two different implementation measures (M).Figure 3 long description.

Figure 4

Figure 4 Estimated TRACE of in-person canvassing intervention on support for transgender non-discrimination law, among those for whom the intervention would have led to an improvement in feelings toward transgender people from baseline (reactive types), across postulated values of the treatment effect among non-reactive types (TRACE(0)). Line segments represent 95% confidence intervals. The number on the far right represents the “naive” ITT estimate, assuming constant treatment effects across strata of M. The gray shaded region represents the intersection of the no-assumption bounds and the range of estimates assuming a value for TRACE(0) less than or equal to the value of the TRACE, in the same direction. The green dots show the point estimates of the no assumption bounds, and corresponding 95% confidence intervals obtained by bootstrap. All models include control variables used in Broockman and Kalla (2016), including baseline levels of both transgender attitudes and policy support.Figure 4 long description.

Figure 5

Figure B1 Latent DAG representation.

Supplementary material: Link

Hazlett et al. Dataset

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