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Current concepts and advances in the application of tissue engineering in otorhinolaryngology and head and neck surgery

Published online by Cambridge University Press:  07 December 2012

E Sivayoham ,
R Saunders ,
B Derby  and
T Woolford
E Sivayoham*
Affiliation:
University Department of Otorhinolaryngology, Manchester Royal Infirmary, UK
R Saunders
Affiliation:
Department of Materials Science, University of Manchester, UK
B Derby
Affiliation:
Department of Materials Science, University of Manchester, UK
T Woolford
Affiliation:
University Department of Otorhinolaryngology, Manchester Royal Infirmary, UK
*
Address for correspondence: Dr E Sivayoham, 1 Pevensey Drive, Knutsford WA16 9BX, UK E-mail: esivay@live.com
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Abstract

Objective:

This paper reviews the progress in the rapidly expanding scientific discipline of tissue engineering, which may have an integral role in the future of otorhinolaryngology. This article seeks to inform on the current concepts and principles of tissue engineering, and describe the state of the art research and developments in this exciting field as applied to ENT and head and neck surgery.

Method:

In order to carry out a comprehensive review of the literature spanning the past 30 years, a search of relevant publications was performed using the Web of Knowledge, Medline and PubMed databases.

Results:

This search identified 85 scholarly articles, which were utilised as the basis of this review.

Conclusion:

Given the current rate of development of tissue engineering research, it is likely that tissue-engineered implants will be widely used in surgical practice, including ENT and head and neck surgery.

Keywords

Tissue EngineeringRhinoplastyTracheaTissue ScaffoldsStem CellsMandibleSalivary Gland

Information

Type
Review Articles
Information
The Journal of Laryngology & Otology , Volume 127 , Issue 2 , February 2013 , pp. 114 - 120
Copyright
Copyright © JLO (1984) Limited 2012

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References

1Langer, R, Vacanti, JP. Tissue engineering. Science 1993;260:920–6CrossRefGoogle ScholarPubMed
2European Commission. “Consultation Document”. Need for a legislative framework for human tissue engineering and tissue-engineered products. In: http://ec.europa.eu/health/files/advtherapies/docs/st09756_en.pdf [29 September 2011]Google Scholar
3Carrel, A, Burrows, MT. Cultivation of tissues in vitro and its technique. J Exp Med 1911;13:387–96CrossRefGoogle ScholarPubMed
4Cilento, BG, Freeman, MR, Schneck, FX, Retik, AB, Atala, A. Phenotypic and cytogenetic characterization of human bladder urothelia expanded in vitro. J Urol 1994;152:665–70CrossRefGoogle ScholarPubMed
5Weissman, IL. Stem cells: units of development, units of regeneration, and units in evolution. Cell 2000;100:157–68CrossRefGoogle ScholarPubMed
6Thomson, JA, Itskovitz-Eldor, J, Shapiro, SS, Waknitz, MA, Swiergiel, JJ, Marshall, VS et al. Embryonic stem cell lines derived from human blastocysts. Science 1998;282:1145–7CrossRefGoogle ScholarPubMed
7McKay, R. Stem cells in the central nervous system. Science 1997;276:66–71CrossRefGoogle ScholarPubMed
8Clark, AT, Bodnar, MS, Fox, M, Rodriquez, RT, Abeyta, MJ, Bodnar, MS et al. Spontaneous differentiation of germ cells from human embryonic stem cells in vitro. Hum Mol Genet 2004;13:727–39CrossRefGoogle ScholarPubMed
9Xu, RH, Chen, X, Li, DS, Li, R, Addicks, GC, Glennon, C et al. BMP4 initiates human embryonic stem cell differentiation to trophoblast. Nat Biotechnol 2002;20:1261–4CrossRefGoogle ScholarPubMed
10Pittenger, MF, Mackay, AM, Beck, SC, Jaiswal, RK, Douglas, R, Mosca, JD et al. Multilineage potential of adult human mesenchymal stem cells. Science 1999;284:143–7CrossRefGoogle ScholarPubMed
11Ferrari, G, Cusella-De Angelis, G, Coletta, M, Paolucci, E, Stornaiuolo, A, Cossu, G et al. Muscle regeneration by bone marrow-derived myogenic progenitors. Science 1998;279:1528–30CrossRefGoogle ScholarPubMed
12Bjornson, CR, Rietze, RL, Reynolds, BA, Magli, MC, Vescovi, AL. Turning brain into blood: a hematopoietic fate adopted by adult neural stem cells in vivo. Science 1999;283:534–7CrossRefGoogle Scholar
13Gimble, JM, Katz, AJ, Bunnell, BA. Adipose-derived stem cells for regenerative medicine. Circ Res 2007;100:1249–60CrossRefGoogle ScholarPubMed
14In 't Anker, PS, Scherjon, SA, Kleijburg-van der Keur, C, Noort, WA, Claas, FH, Willemze, R et al. Amniotic fluid as a novel source of mesenchymal stem cells for therapeutic transplantation. Blood 2003;102:548–9Google ScholarPubMed
15Miura, M, Gronthos, S, Zhao, M, Lu, B, Fisher, LW, Robey, PG et al. SHED: stem cells from human exfoliated deciduous teeth. In: Mahowald, AP ed. Proceedings of the National Academy of Sciences of the United States of America. Chicago: National Academy of Sciences, 2003;100:5807–12Google Scholar
16Pei, M, He, F, Vunjak-Novakovic, G. Synovium derived stem cell-based chondrogenesis. Differentiation 2008;76:1044–56CrossRefGoogle ScholarPubMed
17Zhang, S, Wang, D, Estrov, Z, Raj, S, Willerson, JT, Yeh, ET. Both cell fusion and transdifferentiation account for the transformation of human peripheral blood CD34-positive cells into cardiomyocytes in vivo. Circulation 2004;110:3803–7CrossRefGoogle ScholarPubMed
18Saltzman, W, Olbricht, W. Building drug delivery into tissue engineering. Nat Rev Drug Discov 2002;1:177–86CrossRefGoogle ScholarPubMed
19DiMuzio, P, Tulenko, T. Tissue engineering applications to vascular bypass graft development: the use of adipose-derived stem cells. J Vasc Surg 2007;45(suppl A):99–103CrossRefGoogle ScholarPubMed
20Rosier, RN, O'Keefe, RJ, Crabb, ID, Puzas, JE. Transforming growth factor beta: an autocrine regulator of chondrocytes. Connect Tissue Res 1989;20:295–301CrossRefGoogle ScholarPubMed
21Kitajima, T, Sakuragi, M, Hasuda, H, Ozu, T, Ito, Y. A chimeric epidermal growth factor with fibrin affinity promotes repair of injured keratinocyte sheets. Acta Biomater 2009;5:2623–32CrossRefGoogle ScholarPubMed
22Schneider, RK, Puellen, A, Kramann, R, Raupach, K, Bornemann, J, Bornemann, J et al. The osteogenic differentiation of adult bone marrow and perinatal umbilical mesenchymal stem cells and matrix remodelling in three-dimensional collagen scaffolds. Biomaterials 2010;31:467–80CrossRefGoogle ScholarPubMed
23Lan Levengood, SK, Polak, SJ, Poellmann, MJ, Hoelzle, DJ, Maki, AJ, Clark, SG et al. The effect of BMP-2 on micro- and macroscale osteointegration of biphasic calcium phosphate scaffolds with multiscale porosity. Acta Biomater 2010;6:3283–91CrossRefGoogle ScholarPubMed
24Solorio, L, Zwolinski, C, Lund, AW, Farrell, MJ, Stegemann, JP. Gelatin microspheres crosslinked with genipin for local delivery of growth factors. J Tissue Eng Regen Med 2010;4:514–23CrossRefGoogle ScholarPubMed
25Cruz, DM, Ivirico, JL, Gomes, MM, Ribelles, JL, Sanchez, MS, Reis, RL et al. Chitosan microparticles as injectable scaffolds for tissue engineering. J Tissue Eng Regen Med 2008;2:378–80CrossRefGoogle ScholarPubMed
26Kumari, A, Yadav, SK, Pakade, YB, Singh, B, Yadav, SC. Development of biodegradable nanoparticles for delivery of quercetin. Colloids Surf B Biointerfaces 2010;80:184–92CrossRefGoogle ScholarPubMed
27Place, ES, Evans, ND, Stevens, MM. Complexity in biomaterials for tissue engineering. Nat Mater 2009;8:457–70CrossRefGoogle ScholarPubMed
28Lee, H, Yeo, M, Ahn, S, Kang, DO, Jang, CH, Lee, H et al. Designed hybrid scaffolds consisting of polycaprolactone microstrands and electrospun collagen-nanofibers for bone tissue regeneration. J Biomed Mater Res B Appl Biomater 2011;97:263–70CrossRefGoogle ScholarPubMed
29Johnson, PJ, Tatara, A, McCreedy, DA, Shiu, A, Sakiyama-Elbert, SE. Tissue-engineered fibrin scaffolds containing neural progenitors enhance functional recovery in a subacute model of SCI. Soft Matter 2010;6:5127–37CrossRefGoogle Scholar
30Malafaya, PP, Pedro, AJ, Peterbauer, A, Gabriel, C, Redl, H, Reis, RL. Chitosan particles agglomerated scaffolds for cartilage and osteochondral tissue engineering approaches with adipose tissue derived stem cells. J Mater Sci Mater Med 2005;16:1077–85CrossRefGoogle Scholar
31Badami, AS, Kreke, MR, Thompson, MS, Riffle, JS, Goldstein, AS. Effect of fiber diameter on spreading, proliferation, and differentiation of osteoblastic cells on electrospun poly(lactic acid) substrates. Biomaterials 2006;27:596–606CrossRefGoogle ScholarPubMed
32Boland, ED, Telemeco, TA, Simpson, DG, Wnek, GE, Bowlin, GL. Utilizing acid pretreatment and electrospinning to improve biocompatibility of poly(glycolic acid) for tissue engineering. J Biomed Mater Res B Appl Biomater 2004;71:144–52CrossRefGoogle ScholarPubMed
33Agrawal, CM, Ray, RB. Biodegradable polymeric scaffolds for musculoskeletal tissue engineering. J Biomed Mater Res 2001;55:141–503.0.CO;2-J>CrossRefGoogle ScholarPubMed
34Uyar, T, Havelund, R, Hacaloglu, J, Zhou, X, Besenbacher, F, Kingshott, P. The formation and characterization of cyclodextrin functionalized polystyrene nanofibers produced by electrospinning. Nanotechnology 2009;20:125605CrossRefGoogle ScholarPubMed
35Boland, T, Xu, T, Damon, B, Cui, X. Application of inkjet printing to tissue engineering. Biotechnol J 2006;1:910–17CrossRefGoogle ScholarPubMed
36Campbell, PG, Weiss, LE. Tissue engineering with the aid of inkjet printers. Expert Opin Biol Ther 2007;7:123–7CrossRefGoogle ScholarPubMed
37Nakamura, M, Kobayashi, A, Takagi, F, Watanabe, A, Hiruma, Y, Ohuchi, K et al. Biocompatible inkjet printing technique for designed seeding of individual living cells. Tissue Eng 2005;11:1658–66CrossRefGoogle ScholarPubMed
38Nishiyama, Y, Nakamura, M, Chizuka, H, Kumiko, Shuichi M, Hidemoto, N et al. Development of a three-dimensional bioprinter: construction of cell supporting structures using hydrogel and state-of-the-art inkjet technology. J Biomech Eng 2009;131:035001CrossRefGoogle ScholarPubMed
39Phillippi, JA, Miller, E, Weiss, L, Huard, J, Waggoner, A, Campbell, P. Microenvironments engineered by inkjet bioprinting spatially direct adult stem cells toward muscle- and bone-like subpopulations. Stem Cells 2008;26:127–34CrossRefGoogle ScholarPubMed
40Saunders, RE, Gough, JE, Derby, B. Delivery of human fibroblast cells by piezoelectric drop-on-demand inkjet printing. Biomaterials 2008;29:193–203CrossRefGoogle ScholarPubMed
41Xu, T, Gregory, CA, Molnar, P, Cui, X, Jalota, S, Bhaduri, S et al. Viability and electrophysiology of neural cell structures generated by the inkjet printing method. Biomaterials 2006;27:3580–8Google ScholarPubMed
42Xu, T, Jin, J, Gregory, C, Hickman, J, Boland, T. Inkjet printing of viable mammalian cells. Biomaterials 2005;26:93–9CrossRefGoogle ScholarPubMed
43Yamazoe, H, Tanabe, T. Cell micropatterning on an albumin-based substrate using an inkjet printing technique. J Biomed Mater Res A 2009;91:1202–9CrossRefGoogle Scholar
44Smith, CM, Christian, J, Warren, WL, Williams, SK. Characterizing environmental factors that impact the viability of tissue-engineered constructs fabricated by a direct-write bioassembly tool. Tissue Eng 2007;13:373–83CrossRefGoogle ScholarPubMed
45Smith, CM, Stone, AL, Parkhill, RL, Stewart, RL, Simpkins, MW, Kachurin, AM et al. Three-dimensional bioassembly tool for generating viable tissue-engineered constructs. Tissue Eng 2004;10:1566–76CrossRefGoogle ScholarPubMed
46Vunjak-Novakovic, G. The fundamentals of tissue engineering: scaffolds and bioreactors. Novartis Found Symp 2003;249:34–46CrossRefGoogle ScholarPubMed
47Shiraishi, T, Matsunaga, I, Morishita, S, Takeuchi, R, Saito, T, Mikuni-Takagaki, Y. Tissue-engineered cartilage in three-dimensional cultured chondrocytes by ultrasound stimulation and collagen sponge as scaffold. IMECE2009: Proceedings of the ASME International Mechanical Engineering Congress and Exposition. ASME, 2009;463–4CrossRefGoogle Scholar
48Morgan, EF, Salisbury Palomares, KT, Gleason, RE, Bellin, DL, Chien, KB, Unnikrishnan, GU et al. Correlations between local strains and tissue phenotypes in an experimental model of skeletal healing. J Biomech 2010;43:2418–24CrossRefGoogle Scholar
49Santoro, R, Olivares, AL, Brans, G, Wirz, D, Longinotti, C, Lacroix, D et al. Bioreactor based engineering of large-scale human cartilage grafts for joint resurfacing. Biomaterials 2010;31:8946–52CrossRefGoogle ScholarPubMed
50Giraud, M, Bertschi, D, Guex, G, Nather, S, Fortunato, G, Carrel, TP et al. A new stretching bioreactor for dynamic engineering of muscle tissues. Br J Surg 2010;97(ESSR suppl):S56Google Scholar
51Arnold, HJ, Muller, M, Waldhaus, J, Hahn, H, Lowenheim, H. A novel buoyancy technique optimizes simulated microgravity conditions for whole sensory organ culture in rotating bioreactors. Tissue Eng Part C Methods 2010;16:51–61CrossRefGoogle ScholarPubMed
52Colley, F. Tracheal Resection. An experimental study [German]. Deutsche Ztschr Chir 1895;40:50–62CrossRefGoogle Scholar
53Ferguson, DJ, Wild, JJ, Wangensteen, OH. Experimental resection of the trachea. Surgery 1950;28:597–619Google ScholarPubMed
54Maisel, B, Dingwall, JA. Primary suture of the divided cervical trachea: a preliminary experimental study. Surgery 1950;27:726–9Google ScholarPubMed
55Rethi, A. An operation for cicatricial stenosis of the larynx. J Laryngol Otol 1956;70:283–93CrossRefGoogle ScholarPubMed
56Fearon, B, Cotton, R. Surgical correction of subglottic stenosis of the larynx in infants and children. Progress report. Ann Otol Rhinol Laryngol 1974;83:428–31CrossRefGoogle ScholarPubMed
57Kay, EB. Tracheal resection with primary anastomosis. Ann Otol Rhinol Laryngol 1951;60:864–70CrossRefGoogle ScholarPubMed
58Macchiarini, P, Jungebluth, P, Go, T, Asnaghi, MA, Rees, LE, Cogan, TA et al. Clinical transplantation of a tissue-engineered airway. Lancet 2008;372:2023–30CrossRefGoogle ScholarPubMed
59Weidenbecher, M, Tucker, HM, Awadallah, A, Dennis, JE. Fabrication of a neotrachea using engineered cartilage. Laryngoscope 2008;118:593–8CrossRefGoogle ScholarPubMed
60Park, SS. Reconstruction of nasal defects larger than 1.5 centimeters in diameter. Laryngoscope 2000;110:1241–50CrossRefGoogle ScholarPubMed
61Nagata, S. Modification of the stages in total reconstruction of the auricle: Part I. Grafting the three-dimensional costal cartilage framework for lobule-type microtia. Plast Reconstr Surg 1994;93:221–30CrossRefGoogle ScholarPubMed
62Staudenmaier, R. Optimized auricular reconstruction with autologous cartilage. Experience from 120 cases [German]. HNO 2006;54:749–55CrossRefGoogle ScholarPubMed
63Uppal, RS, Sabbagh, W, Chana, J, Gault, DT. Donor-site morbidity after autologous costal cartilage harvest in ear reconstruction and approaches to reducing donor-site contour deformity. Plast Reconstr Surg 2008;121:1949–55CrossRefGoogle ScholarPubMed
64Cao, Y, Vacanti, JP, Paige, KT, Upton, J, Vacanti, CA. Transplantation of chondrocytes utilizing a polymer-cell construct to produce tissue-engineered cartilage in the shape of a human ear. Plast Reconstr Surg 1997;100:297–302CrossRefGoogle ScholarPubMed
65Yanaga, H, Imai, K, Fujimoto, T, Yanaga, K. Generating ears from cultured autologous auricular chondrocytes by using two-stage implantation in treatment of microtia. Plastic Reconstr Surg 2009;124:817–25CrossRefGoogle ScholarPubMed
66Liu, Y, Zhang, L, Zhou, G, Li, Q, Liu, W, Yu, Z et al. In vitro engineering of human ear-shaped cartilage assisted with CAD/CAM technology. Biomaterials 2010;31:2176–83CrossRefGoogle ScholarPubMed
67Zeng, Y, Wu, W, Yu, H, Yang, J, Chen, G. Silicone implant in augmentation rhinoplasty. Ann Plast Surg 2002;49:495–9CrossRefGoogle ScholarPubMed
68Ham, J, Miller, PJ. Expanded polytetrafluoroethylene implants in rhinoplasty: literature review, operative techniques, and outcome. Facial Plast Surg 2003;19:331–9Google ScholarPubMed
69Cochran, CS, Gunter, JP. Secondary rhinoplasty and the use of autogenous rib cartilage grafts. Clin Plast Surg 2010;37:371–82CrossRefGoogle ScholarPubMed
70Becker, DG, Becker, S, Saad, AA. Auricular cartilage in revision rhinoplasty. Facial Plast Surg 2003;19:41–52CrossRefGoogle ScholarPubMed
71Ishida, LC, Ishida, J, Ishida, LH, Passos, AP, Vieira, J, Henrique Ishida, L et al. Total reconstruction of the alar cartilages with a partially split septal cartilage graft. Ann Plast Surg 2000;45:481–4CrossRefGoogle ScholarPubMed
72Yanaga, H, Imai, K, Yanaga, K. Generative surgery of cultured autologous auricular chondrocytes for nasal augmentation. Aesthetic Plast Surg 2009;33:795–802CrossRefGoogle ScholarPubMed
73Dobratz, EJ, Kim, SW, Voglewede, A, Park, SS. Injectable cartilage: using alginate and human chondrocytes. Arch Facial Plast Surg 2009;11:40–7CrossRefGoogle ScholarPubMed
74Roesink, JM, Moerland, MA, Battermann, JJ, Hordijk, GJ, Terhaard, CH. Quantitative dose-volume response analysis of changes in parotid gland function after radiotherapy in the head-and-neck region. Int J Radiat Oncol Biol Phys 2001;51:938–46CrossRefGoogle ScholarPubMed
75Mariette, X, Gottenberg, J. Pathogenesis of Sjögren's syndrome and therapeutic consequences. Curr Opin Rheumatol 2010;22:471–7CrossRefGoogle ScholarPubMed
76Aframian, DJ, Cukierman, E, Nikolovski, J, Mooney, DJ, Yamada, KM, Baum, BJ. The growth and morphological behavior of salivary epithelial cells on matrix protein-coated biodegradable substrata. Tissue Eng 2000;6:209–16CrossRefGoogle ScholarPubMed
77Hoffman, MP, Kibbey, MC, Letterio, JJ, Kleinman, HK. Role of laminin-1 and TGF-beta 3 in acinar differentiation of a human submandibular gland cell line (HSG). J Cell Sci 1996;109:2013–21CrossRefGoogle ScholarPubMed
78Aframian, DJ, Tran, SD, Cukierman, E, Yamada, KM, Baum, BJ. Absence of tight junction formation in an allogeneic graft cell line used for developing an engineered artificial salivary gland. Tissue Eng 2002;8:871–8CrossRefGoogle Scholar
79Sato, A, Okumura, K, Matsumoto, S, Hattori, K, Hattori, S, Shinohara, M et al. Isolation, tissue localization, and cellular characterization of progenitors derived from adult human salivary glands. Cloning Stem Cells 2007;9:191–205CrossRefGoogle ScholarPubMed
80Aframian, DJ, Palmon, A. Current status of the development of an artificial salivary gland. Tissue Eng Part B Rev 2008;14:187–98CrossRefGoogle ScholarPubMed
81Yang, T, Young, T. Chitosan cooperates with mesenchyme-derived factors in regulating salivary gland epithelial morphogenesis. J Cell Mol Med 2009;13:2853–63CrossRefGoogle ScholarPubMed
82Joraku, A, Sullivan, CA, Yoo, J, Atala, A. In-vitro reconstitution of three-dimensional human salivary gland tissue structures. Differentiation 2007;75:318–24CrossRefGoogle ScholarPubMed
83Emerick, KS, Teknos, TN. State-of-the-art mandible reconstruction using revascularized free-tissue transfer. Expert Rev Anticancer Ther 2007;7:1781–8CrossRefGoogle ScholarPubMed
84Herford, AS, Boyne, PJ. Reconstruction of mandibular continuity defects with bone morphogenetic protein-2 (rhBMP-2). J Oral Maxillofac Surg 2008;66:616–24CrossRefGoogle Scholar
85Duailibi, MT, Duailibi, SE, Young, CS, Bartlett, JD, Vacanti, JP, Yelick, PC. Bioengineered teeth from cultured rat tooth bud cells. J Dent Res Jul;83(7):523–8CrossRefGoogle Scholar