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Increased vascular endothelial growth factor expression predicts a worse prognosis for laryngeal cancer patients: a meta-analysis

Published online by Cambridge University Press:  08 December 2016

L-P Zhang  and
H-L Chen
L-P Zhang*
Affiliation:
Department of Otolaryngology Head and Neck Surgery, Affiliated Hospital of Nantong University, PR China
H-L Chen
Affiliation:
School of Nursing, Nantong University, PR China
*
Address for correspondence: Dr L-P Zhang, Department of Otolaryngology Head and Neck Surgery, Affiliated Hospital of Nantong University, 20 Xi Si Road, Nantong city, Jiangsu, 226001, PR China E-mail: pphss@126.com
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Abstract

Objective:

This study assessed the relationship between vascular endothelial growth factor expression and the laryngeal cancer prognosis.

Methods:

Systematic computerised searches of PubMed were performed up to 31 January 2015. Prognostic endpoints were overall survival and disease-free survival. The pooled hazard ratios for overall survival and disease-free survival were also calculated.

Results:

Seven studies containing 975 patients were included. The pooled hazard ratio was 1.703 (95 per cent confidence interval, 1.373 to 2.112; z score = 4.85, p = 0.000) for overall survival and was 1.918 (95 per cent confidence interval, 1.410 to 2.609; z score = 4.15, p = 0.000) for disease-free survival. No significant publication bias was found. A sensitivity analysis showed that the results were robust. Power analyses also showed there was enough power to detect the calculated hazard ratios.

Conclusion:

The study found that vascular endothelial growth factor overexpression predicted a worse prognosis for laryngeal cancer patients. This supports a strategy of targeted therapy by blocking the vascular endothelial growth factor receptor.

Keywords

Laryngeal NeoplasmsVascular Endothelial Growth FactorsDisease-Free SurvivalSurvivalBiological Markers
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 131 , Issue 1 , January 2017 , pp. 44 - 50
Copyright
Copyright © JLO (1984) Limited 2016 

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