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In vitro activities of fluconazole, itraconazole and voriconazole against otomycotic fungal pathogens

Published online by Cambridge University Press:  20 May 2009

G Yenişehirli ,
Y Bulut ,
M Güven  and
E Günday
G Yenişehirli*
Affiliation:
Department of Microbiology and Clinical Microbiology, Faculty of Medicine, Gaziosmanpaşa University, Tokat, Turkey
Y Bulut
Affiliation:
Department of Microbiology and Clinical Microbiology, Faculty of Medicine, Gaziosmanpaşa University, Tokat, Turkey
M Güven
Affiliation:
Department of Otorhinolaryngology, Faculty of Medicine, Gaziosmanpaşa University, Tokat, Turkey
E Günday
Affiliation:
Department of Microbiology and Clinical Microbiology, Faculty of Medicine, Gaziosmanpaşa University, Tokat, Turkey
*
Address for correspondence: Dr Gülgün Yenişehirli, Gaziosmanpaşa University, Faculty of Medicine, Department of Microbiology and Clinical Microbiology, 60100 Tokat, Turkey. Fax: +90 356 2133176 E-mail: gulguny@gop.edu.tr
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Abstract

Objective:

To determine the causative pathogens of otomycosis, and to evaluate the in vitro activity of antifungal agents against these pathogens.

Materials and methods:

A total of 96 fungal isolate were taken from 92 patients suspected of otomycosis. The in vitro activity of fluconazole, itraconazole and voriconazole against otomycotic pathogens was tested using the E-test method.

Results:

The most common pathogen was Aspergillus fumigatus (40.6 per cent), followed by A niger (35.4 per cent), A flavus (12.5 per cent) and Candida albicans (11.5 per cent). All Aspergillus species were found to be resistant to fluconazole (minimum inhibitory concentration ≥256 µg/ml). The mean minimum inhibitory concentrations of voriconazole for A fumigatus, A niger, A flavus and C albicans were significantly lower than those of itraconazole for the same pathogens.

Conclusion:

This study found that the most common otomycotic fungal pathogen was A fumigatus, and that voriconazole had more potent in vitro activity than itraconazole against all Aspergillus species as well as against C albicans.

Keywords

Otitis ExternaFungus DiseasesAntifungal Agents

Information

Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 123 , Issue 9 , September 2009 , pp. 978 - 981
Copyright
Copyright © JLO (1984) Limited 2009

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