Hostname: page-component-6766d58669-bp2c4 Total loading time: 0 Render date: 2026-05-23T23:49:00.977Z Has data issue: false hasContentIssue false
  • English
  • Français

Can vocal process granuloma location forecast the efficacy of anti-reflux treatment?

Published online by Cambridge University Press:  09 February 2022

J Ding  and
Z Lou Open the ORCID record for Z Lou [Opens in a new window]
J Ding
Affiliation:
Department of Surgery, Yiwu Central Hospital, Yiwu city, China
Z Lou*
Affiliation:
Department of Otorhinolaryngology, Yiwu Central Hospital, Yiwu city, China
*
Author for correspondence: Dr Z Lou, Department of Otorhinolaryngology, Yiwu Central Hospital, 699 Jiangdong road, Yiwu 322000, China E-mail: louzhengcai@163.com
Get access Rights & Permissions [Opens in a new window]

Abstract

Objective

The objective of this study was to evaluate the efficacy of anti-reflux therapy on the idiopathic vocal process granulomas.

Method

This was a prospective case series study. The patients with vocal process granulomas who met the inclusion criteria were analysed. Proton pump inhibitors and vocal hygiene education were conducted for 8–20 weeks.

Results

Of the 16 patients with vocal process granulomas, 5 (31.25 per cent) patients achieved complete remission. The complete remission rate of granulomas was not significantly related to age (p = 1.000), sex (p = 0.296), side (p = 0.299), position (p = 0.100), endoscopic morphology (p = 0.263) or proton pump inhibitor treatment course (p = 0.543) but was significantly associated with granuloma location (p = 0.001) and granuloma size (p = 0.012).

Conclusion

Granulomas in the vocal cord and the margin of the vocal process had an excellent response to proton pump inhibitors, but granulomas on the surface of vocal process and arytenoid cartilage body had little response to proton pump inhibitors. The prolonged period of proton pump inhibitor treatment did not increase the complete remission rate of vocal process granulomas.

Keywords

Vocal FoldArytenoid CartilageProton Pump Inhibitors

Information

Type
Main Article
Information
The Journal of Laryngology & Otology , Volume 137 , Issue 2 , February 2023 , pp. 178 - 185
Copyright
Copyright © The Author(s), 2022. Published by Cambridge University Press on behalf of J.L.O. (1984) LIMITED

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

Article purchase

Temporarily unavailable

Footnotes

Dr Z Lou takes responsibility for the integrity of the content of the paper

References

Lemos, EM, Sennes, LU, Imamura, R, Tsuji, DH. Vocal process granuloma: clinical characterization, treatment and evolution. Braz J Otorhinolaryngol 2005;71:494–8CrossRefGoogle ScholarPubMed
Devaney, KO, Rinaldo, A, Ferlito, A. Vocal process granuloma of the larynx-recognition, differential diagnosis and treatment. Oral Oncol 2005;41:666–9CrossRefGoogle ScholarPubMed
Carroll, TL, Gartner-Schmidt, J, Statham, MM, Rosen, CA. Vocal process granuloma and glottal insufficiency: an overlooked etiology? Laryngoscope 2010;120:114–20CrossRefGoogle ScholarPubMed
Ward, PH, Zwitman, D, Hanson, D, Berci, G. Contact ulcers and granulomas of the larynx: new insights into their etiology as a basis for more rational treatment. Otolaryngol Head Neck Surg 1980;88:262–9CrossRefGoogle ScholarPubMed
Mathew, AS, Menon, JR. “Innocent” arytenoid adduction asymmetry: an etiological survey. Eur Arch Otorhinolaryngol 2021;278:427–35CrossRefGoogle ScholarPubMed
Wang, CP, Ko, JY, Wang, YH, Hu, YL, Hsiao, TY. Vocal process granuloma - a result of long–term observation in 53 patients. Oral Oncol 2009;45:821–5CrossRefGoogle ScholarPubMed
Barrena, BG, Miller, TM, Nelson, BL. Laryngeal contact ulcer. Head Neck Pathol 2020;14:1032–5CrossRefGoogle ScholarPubMed
Karkos, PD, George, M, Van Der Veen, J, Atkinson, H, Dwivedi, RC, Kim, D et al. Vocal process granulomas: a systematic review of treatment. Ann Otol Rhinol Laryngol 2014;123:314–20CrossRefGoogle ScholarPubMed
Tsai, SW, Ma, YF, Shih, LC, Tsou, YA, Sung, CK. Operative and conservative management of laryngeal contact granuloma: a network analysis and systematic review. J Voice 2021;35:300–6CrossRefGoogle ScholarPubMed
Lee, SW, Hong, HJ, Choi, SH, Sun, DI, Park, YH, Lee, BJ et al. Comparison of treatment modalities for contact granuloma: a nationwide multicenter study. Laryngoscope 2014;124:1187–91CrossRefGoogle ScholarPubMed
Pham, Q, Campbell, R, Mattioni, J, Sataloff, R. Botulinum toxin injections into the lateral cricoarytenoid muscles for vocal process granuloma. J Voice 2018;32:363–6CrossRefGoogle ScholarPubMed
Hu, HC, Hung, YT, Lin, SY, Chang, SY. Office-based autologous fat injection laryngoplasty for vocal process granuloma. J Voice 2016;30:758.e7–11CrossRefGoogle ScholarPubMed
Wang, CT, Lai, MS, Lo, WC, Liao, LJ, Cheng, PW. Intralesional steroid injection: an alternative treatment option for vocal process granuloma in ten patients. Clin Otolaryngol 2013;38:77–81CrossRefGoogle ScholarPubMed
Lei, L, Yang, H, Zhang, X, Ren, J. Comparison of the effects of esomeprazole plus mosapride citrate and botulinum toxin A on vocal process granuloma. Am J Otolaryngol 2017;38:593–7CrossRefGoogle ScholarPubMed
Ma, L, Xiao, Y, Ye, J, Yang, Q, Wang, J. Analysis of therapeutic methods for treating vocal process granulomas. Acta Otolaryngol 2015;135:277–82CrossRefGoogle ScholarPubMed
Hillel, AT, Lin, LM, Samlan, R, Starmer, H, Leahy, K, Flint, PW. Inhaled triamcinolone with proton pump inhibitor for treatment of vocal process granulomas: a series of 67 granulomas. Ann Otol Rhinol Laryngol 2010;119:325–0CrossRefGoogle ScholarPubMed
Farwell, DG, Belafsky, PC, Rees, CJ. An endoscopic grading system for vocal process granuloma. J Laryngol Otol 2008;122:1092–5CrossRefGoogle ScholarPubMed
Boom, L, Edens, M, Rinia, B. Reflux finding score and reflux symptom index as potential predictors for proton pump inhibitor response in globus pharyngeus patients: a prospective study. Auris Nasus Larynx 2020;47:609–15CrossRefGoogle ScholarPubMed
Havas, TE, Priestley, J, Lowinger, DS. A management strategy for vocal process granulomas. Laryngoscope 1999;109:301–6CrossRefGoogle ScholarPubMed
Wani, MK, Woodson, GE. Laryngeal contact granuloma. Laryngoscope 1999;109:1589–93CrossRefGoogle ScholarPubMed
Halum, SL, Miller, P, Early, K. Laryngeal granulomas associated with superior laryngeal nerve paresis J Voice. 2010;24:490–93CrossRefGoogle ScholarPubMed
Lin, DS, Cheng, SC, Su, WF. Potassium titanyl phosphate laser treatment of intubation vocal granuloma. Eur Arch Otorhinolaryngol 2008;265:1233–8CrossRefGoogle ScholarPubMed
Lee, DH, Yoon, TM, Lee, JK, Lim, SC. Surgical treatment outcomes of vocal process granuloma after endotracheal intubation. J Craniofac Surg 2018;29:e387–9CrossRefGoogle ScholarPubMed
de Lima Pontes, PA, De Biase, NG, Gadelha, EC. Clinical evolution of laryngeal granulomas: treatment and prognosis. Laryngoscope 1999;109:289–94CrossRefGoogle ScholarPubMed
Emami, AJ, Morrison, M, Rammage, L, Bosch, D. Treatment of laryngeal contact ulcers and granulomas: a 12-year retrospective analysis. J Voice 1999;13:612–17CrossRefGoogle ScholarPubMed
Chou, YS, Jiang, HJ, Chen, CH, Ho, PS, Lee, TC. Proton pump inhibitor use and risk of hip fracture in patients with type 2 diabetes. Sci Rep 2020;10:14081CrossRefGoogle ScholarPubMed
Min, YW, Lee, YC, Kim, K, Ryu, S, Hong, KS, Jeon, HH et al. Proton pump inhibitor use is associated with hip fracture development: a nationwide population-based cohort study. Korean J Intern Med 2020;35:1084–93CrossRefGoogle ScholarPubMed
Park, JH, Lee, J, Yu, SY, Jung, J-H, Han, K, Kim, D-H et al. Comparing proton pump inhibitors with histamin-2 receptor blockers regarding the risk of osteoporotic fractures: a nested case-control study of more than 350,000 Korean patients with GERD and peptic ulcer disease. BMC Geriatr 2020;20:407CrossRefGoogle ScholarPubMed
Hamdan, AL, Khalifee, E, Jaffal, H, Ghanem, A. Interarytenoid botulinum toxin A injection for the treatment of vocal process granuloma. J Laryngol Otol 2019;133:1041–5CrossRefGoogle ScholarPubMed
Fink, DS, Achkar, J, Franco, RA, Song, PC. Interarytenoid botulinum toxin injection for recalcitrant vocal process granuloma. Laryngoscope 2013;123:3084–7CrossRefGoogle ScholarPubMed