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Plasma levels of endothelial cell-specific molecule-1 and pentraxin-3 in idiopathic sudden sensorineural hearing loss

Published online by Cambridge University Press:  29 October 2018

F Gündoğan ,
A Bayram ,
M Kalkan  and
İ Özcan
F Gündoğan
Affiliation:
Department of ENT, Boğazlıyan State Hospital, Kayseri, Turkey
A Bayram*
Affiliation:
Department of ENT, Kayseri Training and Research Hospital, Turkey
M Kalkan
Affiliation:
Department of ENT, Kayseri Training and Research Hospital, Turkey
İ Özcan
Affiliation:
Department of ENT, Kayseri Training and Research Hospital, Turkey
*
Author for correspondence: Dr Ali Bayram, Kayseri Training and Research Hospital, Sanayi Mah. Atatürk Bulvarı Hastane Cad. No: 78, Kayseri 38010, Turkey E-mail: dralibayram@gmail.com Fax: +90 352 3207313
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Abstract

Objectives

To evaluate the plasma levels of endothelial cell-specific molecule-1 (ESM-1) and pentraxin-3 (PTX-3) in patients with idiopathic sudden sensorineural hearing loss, and to compare the pre- and post-treatment levels in patients responsive and non-responsive to therapy.

Methods

The study included 108 subjects: 51 with idiopathic sudden sensorineural hearing loss and 57 controls. For ESM-1 and PTX-3 analyses, blood samples were collected before and three months after treatment initiation in the idiopathic sudden sensorineural hearing loss group and once for the control group. Treatment response was evaluated three months after therapy initiation with pure tone audiometry, and the patients were divided into two groups: responsive and non-responsive to treatment.

Results

Serum ESM-1 levels were significantly higher in the idiopathic sudden sensorineural hearing loss group than the control group, whereas the difference was not significant for PTX-3. In the responsive and non-responsive groups, ESM-1 and PTX-3 levels were not statistically different before and after treatment.

Conclusion

To our knowledge, this is the first study investigating plasma ESM-1 and PTX-3 levels in idiopathic sudden sensorineural hearing loss. Increased plasma ESM-1 levels may confirm endothelial dysfunction involvement in idiopathic sudden sensorineural hearing loss pathogenesis, which could be associated with vascular impairment.

Keywords

Hearing Loss, SuddenEndotheliumVascular Endothelial Cells
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 132 , Issue 11 , November 2018 , pp. 995 - 999
Copyright
Copyright © JLO (1984) Limited, 2018 

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Footnotes

Dr A Bayram takes responsibility for the integrity of the content of the paper

Presented at the 39th Turkish National Congress of Otolaryngology Head and Neck Surgery, 8–12 November 2017, Antalya, Turkey.

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