Hostname: page-component-77f85d65b8-5ngxj Total loading time: 0 Render date: 2026-03-29T08:38:24.142Z Has data issue: false hasContentIssue false
  • English
  • Français

Effect of nasolacrimal duct obstruction on nasal mucociliary transport

Published online by Cambridge University Press:  30 October 2009

B Naiboglu ,
I Deveci ,
C Kalaycik ,
A Daylan ,
T E Habesoglu ,
S Z Toros ,
S E Deveci  and
E Egeli
B Naiboglu*
Affiliation:
Otorhinolaryngology Clinic, Haydarpasa Numune Education and Research Hospital, Istanbul, Turkey
I Deveci
Affiliation:
Otorhinolaryngology Clinic, Haydarpasa Numune Education and Research Hospital, Istanbul, Turkey
C Kalaycik
Affiliation:
Otorhinolaryngology Clinic, Haydarpasa Numune Education and Research Hospital, Istanbul, Turkey
A Daylan
Affiliation:
Ophthalmology Clinic, Haydarpasa Numune Education and Research Hospital, Istanbul, Turkey
T E Habesoglu
Affiliation:
Otorhinolaryngology Clinic, Haydarpasa Numune Education and Research Hospital, Istanbul, Turkey
S Z Toros
Affiliation:
Otorhinolaryngology Clinic, Haydarpasa Numune Education and Research Hospital, Istanbul, Turkey
S E Deveci
Affiliation:
Otolaryngology Clinic, Fatih Sultan Mehmet Education and Research Hospital, Istanbul, Turkey
E Egeli
Affiliation:
Otorhinolaryngology Clinic, Haydarpasa Numune Education and Research Hospital, Istanbul, Turkey
*
Address for correspondence: Dr B Naiboglu, Haydarpasa Numune Hastanesi, Tıbbiye Caddesi No 18, PK 34668 Selimiye, Uskudar, İstanbul, Turkey. Fax: 00902163360565 E-mail: drbnaib@yahoo.com
Get access Rights & Permissions [Opens in a new window]

Abstract

Background:

Most patients with nasolacrimal duct obstruction have dry, crusty nasal mucosa. Mucociliary clearance is modulated by the amount and biochemical composition of nasal mucus. Nasolacrimal duct obstruction disturbs the drainage of tears into the nasal cavity.

Objective:

We examined the effect of nasolacrimal duct obstruction on the mucociliary transport of nasal mucosa, by comparing saccharine test results for epiphora patients versus healthy volunteers.

Study design:

Prospective, randomised, clinical trial.

Methods:

Eight patients with bilateral epiphora and 10 patients with unilateral epiphora were included in the study group. Complete nasolacrimal duct obstruction was demonstrated by studying irrigation of the nasolacrimal system, and by fluorescein dye study. The control group comprised 20 healthy volunteers. Mucociliary transport was assessed by the saccharine test in both the study and control groups. The saccharine transit times of 26 impaired nasal cavities were compared with those of 20 healthy nasal cavities of controls. Also, the saccharine transit times of the healthy nasal cavities of the 10 patients with unilateral epiphora were compared with those of their diseased sides, and also with those of healthy volunteers.

Results:

The saccharine transit times of the epiphora patients were statistically significantly greater than those of the control group. Also, there was a statistically significant difference in saccharine transit times, comparing the healthy and impaired nasal cavities of patients with unilateral epiphora.

Conclusion:

Nasolacrimal duct obstruction has a negative effect on nasal mucociliary clearance. This may be related to changes in the amount and biochemical composition of nasal mucus.

Keywords

Nasolacrimal DuctEpiphoraNasal MucosaMucociliary Transport

Information

Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 124 , Issue 2 , February 2010 , pp. 166 - 170
Copyright
Copyright © JLO (1984) Limited 2009

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

Article purchase

Temporarily unavailable

References

1Cohen, NA. Sinonasal mucociliary clearance in health and disease. Ann Otol Rhinol Laryngol Suppl 2006;196:20–6CrossRefGoogle ScholarPubMed
2Perry, HD. Dry eye disease: pathophysiology, classification, and diagnosis. Am J Manag Care 2008;14(suppl):79–87Google Scholar
3Anonymous. The definition and classification of dry eye disease: report of the Definition and Classification Subcommittee of the International Dry Eye Workshop (2007). Ocul Surf 2007;5:75–92CrossRefGoogle Scholar
4Gilbard, JP. The diagnosis and management of dry eyes. Otolaryngol Clin North Am 2005;38:871–85CrossRefGoogle ScholarPubMed
5Montes, MR. Role of the tear film in the optical quality of the human eye. J Cataract Refract Surg 2007;33:1631–5CrossRefGoogle Scholar
6Klenker, B, Sheardown, H. Growth factors in the anterior segment: role in tissue maintenance, wound healing and ocular pathology. Exp Eye Res 2004;79:677–88Google Scholar
7Foulks, GN. The correlation between the tear film lipid layer and dry eye disease. Surv Ophthalmol 2007;52:369–74CrossRefGoogle ScholarPubMed
8Zaldivar, RA, Buerger, DG, Woog, JJ. Office evaluation of lacrimal and orbital disease. Otolaryngol Clin North Am 2006;39:911–22CrossRefGoogle ScholarPubMed
9Mills, DM, Meyer, DR. Acquired nasolacrimal duct obstruction. Otolaryngol Clin North Am 2006;39:979–99CrossRefGoogle ScholarPubMed
10Sanderson, MJ, Dirksen, ER. Mechanosensitivity of cultured ciliated cells from the mammalian respiratory tract: implications for the regulation of mucociliary transport. Proc Natl Acad Sci USA 1986;83:7302–6CrossRefGoogle ScholarPubMed
11Wong, LB, Miller, IF, Yeates, DB. Stimulation of tracheal ciliary beat frequency by capsaicin. J Appl Physiol 1990;68:2574–80CrossRefGoogle ScholarPubMed
12Jain, B, Rubinstein, I, Robbins, RA, Leise, KL, Sisson, JH. Modulation of airway epithelial cell ciliary beat frequency by nitric oxide. Biochem Biophys Res Commun 1993;191:83–8CrossRefGoogle ScholarPubMed
13Sanderson, MJ, Dirksen, ER. Mechanosensitive and beta-adrenergic control of the ciliary beat frequency of mammalian respiratory tract cells in culture. Am Rev Respir Dis 1989;139:432–40CrossRefGoogle ScholarPubMed
14Mwimbi, XK, Muimo, R, Gren, MW, Mehta, A. Making human nasal cilia beat in the cold: a real time assay for cell signalling. Cell Signal 2003;15:395–402CrossRefGoogle Scholar
15Gren, A, Smallman, LA, Logan, AC, Drake-Lee, AB. The effect of temperature on nasal ciliary beat frequency. Clin Otolaryngol Allied Sci 1995;20:178–80CrossRefGoogle Scholar
16Houtmeyers, E, Gosselink, R, Gayan, RG, Decramer, M. Regulation of mucociliary clearance in health and disease. Eur Respir J 1999;13:1177–88CrossRefGoogle ScholarPubMed
17Satir, P, Sleigh, MA. The physiology of cilia and mucociliary interactions. Annu Rev Physiol 1990;52:137–55Google ScholarPubMed
18Verdugo, P. Goblet cells secretion and mucogenesis. Annu Rev Physiol 1990;52:157–76CrossRefGoogle ScholarPubMed
19Girod, S, Zahm, JM, Plotkowski, C, Beck, G, Puchelle, E. Role of the physiochemical properties of mucus in the protection of the respiratory epithelium. Eur Respir J 1992;5:477–87Google ScholarPubMed
20Clary-Meinesz, CF, Cosson, J, Huitorel, P, Blaive, B. Temperature effect on the ciliary beat frequency of human nasal and tracheal ciliated cells. Biol Cell 1992;76:335–8CrossRefGoogle ScholarPubMed
21Salah, B, Dinh Xuan, AT, Fouilladier, JL, Lockhart, A, Regnard, J. Nasal mucociliary transport in healthy subjects is slower when breathing dry air. Eur Respir J 1988;1:852–5CrossRefGoogle ScholarPubMed
22Majima, Y, Sakakura, Y, Matsabura, T, Miyoshi, Y. Possible mechanisms of reduction of nasal mucociliary clearance in chronic sinusitis. Clin Otolaryngol Allied Sci 1986;11:55–60CrossRefGoogle ScholarPubMed
23Sun, SS, Hsieh, JF, Tsai, SC, Ho, YJ, Kao, CH. The role of rhinoscintigraphy in the evaluation of nasal mucociliary clearance function in patients with sinusitis. Nucl Med Commun 2000;21:1029–32CrossRefGoogle ScholarPubMed
24Atsuta, S, Majima, Y. Nasal mucociliary clearance of chronic sinusitis in relation to rheological properties of nasal mucus. Ann Otol Rhinol Laryngol 1998;107:47–51CrossRefGoogle ScholarPubMed
25Passali, D, Feri, R, Becchini, G, Passali, GC, Bellussi, L. Alterations of nasal mucociliary transport in patients with hypertrophy of the inferior turbinates, deviations of the nasal septum and chronic sinusitis. Eur Arch Otorhinolaryngol 1999;256:335–7Google ScholarPubMed
26Asai, K, Haruna, S, Otori, N, Yanagi, K, Fukami, M, Moriyama, H. Saccharin test of maxillary sinus mucociliary function after endoscopic sinus surgery. Laryngoscope 2000;110:117–22CrossRefGoogle ScholarPubMed
27Kaluskar, SK. Pre- and postoperative mucociliary clearance in functional endoscopic sinus surgery. Ear Nose Throat J 1997;76:884–6CrossRefGoogle ScholarPubMed
28Hafner, B, Davris, S, Riechelmann, H, Mann, WJ, Amedee, RG. Endonasal sinus surgery improves mucociliary transport in severe chronic sinusitis. Am J Rhinol 1997;11:271–4CrossRefGoogle ScholarPubMed