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Development of cavernous haemangioma following radical chemo-radiotherapy for nasopharyngeal carcinoma

Published online by Cambridge University Press:  08 March 2017

J R Ellenbogen ,
S M Joshi  and
N Kitchen
J R Ellenbogen
Affiliation:
Department of Neurosurgery, The National Hospital for Neurology and Neurosurgery, London, UK
S M Joshi
Affiliation:
Department of Neurosurgery, The National Hospital for Neurology and Neurosurgery, London, UK
N Kitchen*
Affiliation:
Department of Neurosurgery, The National Hospital for Neurology and Neurosurgery, London, UK
*
Address for correspondence: Mr N Kitchen, Consultant Neurosurgeon, The National Hospital for Neurology & Neurosurgery, London, WC1N 3BG, UK. E-mail: neil.kitchen@uclh.nhs.uk
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Abstract

Objective:

We report an adult case of nasopharyngeal carcinoma treated with radical chemo-radiotherapy, with subsequent development of a histologically proved temporal cavernous haemangioma within the radiation field.

Method:

Case report and review of the current literature concerning radiation-induced, secondary, space-occupying lesions.

Conclusion:

The increasing role of radiotherapy in nasopharyngeal carcinoma treatment, together with improved patient survival, is likely to lead to radiation-induced, secondary, space-occupying lesions being encountered more frequently. We emphasise the need to be vigilant for this important but relatively rare complication, which has significant associated morbidity.

Keywords

Cavernous HemangiomaRadiotherapyNasopharyngeal Carcinoma

Information

Type
Clinical Records
Information
The Journal of Laryngology & Otology , Volume 123 , Issue 8 , August 2009 , pp. 925 - 927
Copyright
Copyright © JLO (1984) Limited 2008

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References

1 Jeyakumar, A, Brickman, TM, Jeyakumar, A, Doerr, T. Review of nasopharyngeal carcinoma. Ear Nose Throat J 2006;85:168–74CrossRefGoogle ScholarPubMed
2 King, AD, Ahuja, AT, Teo, P, Tse, GMK, Kew, J. Radiation induced sarcomas of the head and neck following radiotherapy for nasopharyngeal carcinoma. Clin Radiol 2000;55:684–9CrossRefGoogle ScholarPubMed
3 Cheng, KM, Chan, CM, Fu, YT, Ho, YW, Tsang, YW, Lee, MK et al. Brain abscess formation in radiation necrosis of the temporal lobe following radiation therapy for nasopharyngeal carcinoma. Acta Neurochir (Wien) 2000;142:435–41CrossRefGoogle ScholarPubMed
4 Goh, YH, Chong, VF, Low, WK. Temporal bone tumours in patients irradiated for nasopharyngeal neoplasms. J Laryngol Otol 1999;113:222–8CrossRefGoogle Scholar
5 Kong, L, Lu, JJ, Hu, C, Guo, X, Wu, Y, Zhang, Y. The risk of secondary primary tumors in patients with nasopharyngeal carcinoma after definitive radiotherapy. Cancer 2006;107:1287–93CrossRefGoogle Scholar
6 Nimjee, SM, Power, CJ, Bulsara, KR. Review of the literature on de novo formation of cavernous malformations of the central nervous system after radiation therapy. Neurosurg Focus 2006;21:1–6CrossRefGoogle ScholarPubMed
7 Burn, S, Gunny, R, Phipps, K, Gaze, M, Haywood, R. Incidence of cavernoma development in children after radiotherapy for brain tumors. J Neurosurg 2007;106:379–83Google ScholarPubMed
8 Baumgartner, JE, Ater, JL, Ha, CS, Kuttesch, JF, Leeds, NE, Fuller, GN et al. Pathologically proven cavernous angiomas of the brain following radiation therapy for pediatric brain tumours. Pediatr Neurosurg 2003;39:201–7CrossRefGoogle Scholar
9 Amirjamshidi, A, Abbassioun, K. Radiation-induced tumors of the central nervous system occurring in childhood and adolescence. Childs Nerv Syst 2000;16:390–7CrossRefGoogle ScholarPubMed
10 Robinson, JR, Awad, IA, Little, JR. Natural history of the cavernous angioma. J Neurosurg 1991;75:709–14CrossRefGoogle ScholarPubMed
11 Curling, OD, Kelly, DL, Elster, AD, Craven, TE. An analysis of the natural history of cavernous angiomas. J Neurosurg 1991;75:702–8CrossRefGoogle ScholarPubMed
12 Furuse, M, Miyatake, SL, Kuroiwa, T. Cavernous malformation after radiation therapy for astrocytoma in adult patients: report of 2 cases. Acta Neurochir (Wien) 2005;147:1097–101CrossRefGoogle Scholar
13 Heckl, S, Achoff, A, Kunze, S. Radiation-induced cavernous hemangiomas of the brain. Cancer 2002;94:3285–91CrossRefGoogle ScholarPubMed
14 Gaensler, EH, Dillon, WP, Edwards, MS, Larson, DA, Rosenau, W, Wilson, CB. Radiation-induced telangiectasia in the brain simulates cryptic vascular malformations at MR imaging. Radiology 1994;193:629–36CrossRefGoogle ScholarPubMed