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Diffuse lipomatosis of the thyroid with amyloid deposition

Published online by Cambridge University Press:  23 January 2013

T A Jacques  and
M P Stearns
T A Jacques*
Affiliation:
Department of ENT, Lister Hospital, Stevenage, UK
M P Stearns
Affiliation:
Department of ENT, Royal Free Hospital, London, UK
*
Address for correspondence: Dr T A Jacques, Department of ENT, Lister Hospital, Corey's Mill Lane, Stevenage SG1 4AB, UK E-mail: tjacques@doctors.org.uk
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Abstract

Background:

The authors present a case of diffuse fatty infiltration of the thyroid gland with coexistent deposition of amyloid protein.

Method:

A case history and brief literature review concerning amyloid goitre and fatty infiltration of the thyroid are presented, and the relationship between these two phenomena is discussed.

Results:

A patient with AA amyloidosis presented with a slowly enlarging goitre, which on histological examination was extensively infiltrated with adipose tissue. Amyloid protein was found on Congo red staining.

Conclusion:

To our best knowledge, this patient represents the first reported case of diffuse lipomatosis of the thyroid gland causing goitre in a patient with AA amyloidosis. The presence of amyloid protein within the thyroid was not sufficient to cause enlargement per se, and was therefore of unclear significance. Together with previous reports of the concurrent deposition of amyloid and fat, this case raises questions as to the relationship between these two phenomena.

Keywords

GoiterThyroid GlandLipomatosisAmyloidosisAdipose TissueLipomaPathology

Information

Type
Clinical Records
Information
The Journal of Laryngology & Otology , Volume 127 , Issue 4 , April 2013 , pp. 426 - 428
Copyright
Copyright © JLO (1984) Limited 2013

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References

1Dhayagude, RG. Massive fatty infiltration in a colloid goiter. Arch Pathol 1942;33:357–60Google Scholar
2Schröder, S, Böcker, W. Lipomatous lesions of the thyroid gland: a review. Appl Pathol 1985;3:140–9Google ScholarPubMed
3LaForga, JB, Vierna, J. Adenoma of thyroid gland containing fat (thyrolipoma). Report of a case. J Laryngol Otol 1996;110:1088–9CrossRefGoogle ScholarPubMed
4Himmetoglu, C, Yamak, S, Tezel, GG. Diffuse fatty infiltration in amyloid goiter. Pathol Int 2007;57:449–53CrossRefGoogle ScholarPubMed
5Di Scioscio, V, Loffreda, V, Feraco, P, Luccaroni, R, Palena, M, Balbi, T et al. Diffuse lipomatosis of thyroid gland. J Clin Endocrinol Metab 2008;93:8–9CrossRefGoogle ScholarPubMed
6Hamed, G, Hefess, CS, Shmookler, BM, Wenig, BM. Amyloid goiter. A clinicopathological study of 14 cases and review of the literature. Am J Clin Pathol 1995;104:306–12CrossRefGoogle ScholarPubMed
7Arean, VM, Klein, RE. Amyloid goiter. Review of the literature and report of a case. Am J Clin Pathol 1961;36:341–55CrossRefGoogle ScholarPubMed
8Arslan, A, Alíç, B, Uzunlar, AK, Büyükbayram, H, Sarí, I. Diffuse lipomatosis of thyroid gland. Auris Nasus Larynx 1999;26:213–15CrossRefGoogle ScholarPubMed