Hostname: page-component-76fb5796d-r6qrq Total loading time: 0 Render date: 2024-04-25T18:25:09.270Z Has data issue: false hasContentIssue false

Facial neuritis in coronavirus disease 2019 associated mucormycosis: study on clinico-radiological correlates

Published online by Cambridge University Press:  31 January 2022

A S Jaiswal
Affiliation:
Department of Otorhinolaryngology and Head – Neck Surgery, All India Institute of Medical Sciences, New Delhi, India
K Sikka*
Affiliation:
Department of Otorhinolaryngology and Head – Neck Surgery, All India Institute of Medical Sciences, New Delhi, India
A S Bhalla
Affiliation:
Department of Radiology, All India Institute of Medical Sciences, New Delhi, India
S Manchanda
Affiliation:
Department of Radiology, All India Institute of Medical Sciences, New Delhi, India
G Goel
Affiliation:
Department of Otorhinolaryngology and Head – Neck Surgery, All India Institute of Medical Sciences, New Delhi, India
H Verma
Affiliation:
Department of Otorhinolaryngology and Head – Neck Surgery, All India Institute of Medical Sciences, New Delhi, India
A Thakar
Affiliation:
Department of Otorhinolaryngology and Head – Neck Surgery, All India Institute of Medical Sciences, New Delhi, India
*
Author for correspondence: Dr Kapil Sikka, Room number 4063, 4th Floor, Department of Otorhinolaryngology and Head – Neck Surgery, All India Institute of Medical Sciences, New Delhi110029, India E-mail: kapil_sikka@yahoo.com

Abstract

Objective

To elucidate the aetiopathogenesis of facial neuritis in coronavirus disease 2019 associated mucormycosis.

Methods

A retrospective review was conducted of coronavirus disease 2019 associated mucormycosis patients who presented with peripheral facial nerve palsy from January 2021 to July 2021. The clinico-radiological details of four patients were assessed to examine the potential mechanism of facial nerve involvement.

Results

Serial radiological evaluation with contrast-enhanced computed tomography and contrast-enhanced magnetic resonance imaging revealed infratemporal fossa involvement in all cases, with the inflammation extending along fascial planes to reach the stylomastoid foramen. Ascending neuritis with an enhancement of the facial nerve was demonstrated in all cases.

Conclusion

The likely explanation for facial palsy in patients with coronavirus disease 2019 associated mucormycosis, backed by radiology, is the disease abutting the facial nerve at the stylomastoid foramen and causing ascending neuritis of the facial nerve.

Type
Main Article
Copyright
Copyright © The Author(s), 2022. Published by Cambridge University Press on behalf of J.L.O. (1984) LIMITED.

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

Footnotes

Dr K Sikka takes responsibility for the integrity of the content of the paper

References

Cornely, OA, Alastruey-Izquierdo, A, Arenz, D, Chen, SCA, Dannaoui, E, Hochhegger, B et al. Global guideline for the diagnosis and management of mucormycosis: an initiative of the European Confederation of Medical Mycology in cooperation with the Mycoses Study Group Education and Research Consortium. Lancet Infect Dis 2019;19:e405–21CrossRefGoogle Scholar
Mane, R, Patil, B, Mohite, A, Mohanty, R. Facial nerve palsy: an unusual presentation in patients with rhino cerebral mucormycosis. Indian J Otolaryngol Head Neck Surg 2019;71(suppl 3):2110–13CrossRefGoogle ScholarPubMed
Hosseini, SM, Borghei, P. Rhinocerebral mucormycosis: pathways of spread. Eur Arch Otorhinolaryngol 2005;262:932–8CrossRefGoogle Scholar
Shekar, V, Sikander, J, Rangdhol, V, Naidu, M. Facial nerve paralysis: a case report of rare complication in uncontrolled diabetic patient with mucormycosis. J Nat Sci Biol Med 2015;6:226–8CrossRefGoogle ScholarPubMed
Chandu, A, MacIsaac, RJ, MacGregor, DP, Campbell, MC, Wilson, MJ, Bach, LA. A case of mucormycosis limited to the parotid gland. Head Neck 2005;27:1108–11CrossRefGoogle ScholarPubMed
Gochhait, D, Alexender, A, Dehuri, P, Rangarajan, V, Jacob, SE, Siddaraju, N. Mucormycotic parotitis and otitis causing facial nerve palsy in a diabetic patient. Cytopathology 2018;29:582–4CrossRefGoogle ScholarPubMed
Margo, CE, Linden, C, Strickland-Marmol, LB, Denietolis, AL, McCaffrey, JC, Kirk, N. Rhinocerebral mucormycosis with perineural spread. Ophthalmic Plast Reconstr Surg 2007;23:326–7CrossRefGoogle ScholarPubMed
Parsi, K, Itgampalli, RK, Vittal, R, Kumar, A. Perineural spread of rhino-orbitocerebral mucormycosis caused by Apophysomyces elegans. Ann Indian Acad Neurol 2013;16:414–17CrossRefGoogle ScholarPubMed
McLean, FM, Ginsberg, LE, Stanton, CA. Perineural spread of rhinocerebral mucormycosis. AJNR Am J Neuroradiol 1996;17:114–16Google ScholarPubMed
Aloosi, SN. Facial nerve palsy as frequent presentation in patient with rhinocerebral mucormycosis. J Oral Dental Res 2018;5:5569Google Scholar