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Diagnostic tests for immunomediated hearing loss: a systematic review

Published online by Cambridge University Press:  02 October 2007

D Lobo ,
F García López ,
J R García-Berrocal  and
R Ramírez-Camacho
D Lobo*
Affiliation:
Ear Research Group, Department of Otorhinolaryngology, Hospital Universitario Puerta de Hierro, Universidad Autónoma de Madrid, Spain
F García López
Affiliation:
Department of Epidemiology, Hospital Universitario Puerta de Hierro, Universidad Autónoma de Madrid, Spain
J R García-Berrocal
Affiliation:
Ear Research Group, Department of Otorhinolaryngology, Hospital Universitario Puerta de Hierro, Universidad Autónoma de Madrid, Spain
R Ramírez-Camacho
Affiliation:
Ear Research Group, Department of Otorhinolaryngology, Hospital Universitario Puerta de Hierro, Universidad Autónoma de Madrid, Spain
*
Address for correspondence: Dr David Lobo, Hospital Universitario Puerta de Hierro, Universidad Autónoma de Madrid, San Martín de Porres 4 28035, Madrid, Spain. Fax:  + 34913730535 E-mail: d.lobo@excite.com
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Abstract

Objective:

To quantitatively evaluate the diagnostic accuracy of diagnostic tests for immunomediated hearing loss.

Data sources:

We searched Medline and the Cochrane Database of Systematic Reviews for potentially relevant studies.

Study selection:

Twenty-five studies met the inclusion criteria of this systematic review. The diagnosis of immunomediated hearing loss was based on the clinical presentation and the response to corticosteroid administration.

Data extraction:

The following data were extracted from the selected studies and entered into a standardised database: population demographics; exclusion and inclusion criteria; diagnostic tests; sensitivity; specificity; the number of true positive, true negative, false positive and false negative values; therapy used, including dose and duration; and delay between symptom onset and therapy commencement.

Data synthesis:

This systematic review combined data from 679 patients with immunomediated hearing loss, reported by 22 research teams. Substantial heterogeneity was found among the included studies; for this reason, summary sensitivity and specificity values were not computed.

Conclusions:

The results of diagnostic tests for immunomediated hearing loss depend on many factors, and there is a risk of potential bias. This is the first time that such a systematic review has been presented; such a review is a more rigorous method of demonstrating the utility of the available diagnostic tests.

Keywords

AutoimmunityInner EarVestibular DisordersSensorineural Deafness

Information

Type
Main Article
Information
The Journal of Laryngology & Otology , Volume 122 , Issue 6 , June 2008 , pp. 564 - 573
Copyright
Copyright © JLO (1984) Limited 2007

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