Hostname: page-component-8448b6f56d-xtgtn Total loading time: 0 Render date: 2024-04-25T01:46:30.441Z Has data issue: false hasContentIssue false
  • English
  • Français

Malignant oncocytoma of the parotid gland: a case report with an immunohistochemical and ultrastructural study

Published online by Cambridge University Press:  29 June 2007

Takuya Sugimoto ,
Shigeki Wakizono ,
Takuya Uemura ,
Masazumi Tsuneyoshi  and
Munetomo Enjoji
Takuya Sugimoto*
Affiliation:
Department of Otorhinolaryngology, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
Shigeki Wakizono
Affiliation:
Department of Otorhinolaryngology, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
Takuya Uemura
Affiliation:
Department of Otorhinolaryngology, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
Masazumi Tsuneyoshi
Affiliation:
Second Department of Pathology, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
Munetomo Enjoji
Affiliation:
Second Department of Pathology, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
*
Takuya Sugimoto, M.D., Department of Otorhinolaryngology, School of Medicine,University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu 807, Japan. Fax: 010-81-93-601-7554
Get access Rights & Permissions [Opens in a new window]

Abstract

A rare case of a 71 -year-old man with malignant oncocytoma is presented. The tumour was found in the left parotid region with enlarged lymph nodes in the neck. The resected parotid mass consisted of three discrete nodules, each histologically characterized by a uniform proliferation of oncocytic tumour cells. The patient underwent repeated operations for recurrences and metastases, and eventually died of acute pneumonia 18 months after the first admission. Metastases to the lymph nodes, ribs, spine and liver had been clinically pointed out. Immunohistochemically, the tumour cells were positive for a-1-antitrypsin, a-1-antichymotrypsin, lactoferrin, secretory component and carcinoembryonic antigen (CEA), while they were negative for S-100 protein and HHF35 (muscle specific actin). Ultrastructural pictures disclosed numerous mitochondria in the cytoplasm of the tumour cells, revealing neither myofibrils nor secretory granules. These findings therefore support the concept that this tumour is of a glandular epithelial origin.

Keywords

Parotid neoplasmsmalignant oncocytoma
Type
Pathology in Focus
Information
The Journal of Laryngology & Otology , Volume 107 , Issue 1 , January 1993 , pp. 69 - 74
Copyright
Copyright © JLO (1984) Limited 1993

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Askew, J. B. Jr., Fechner, R. E., Bentinck, D. C., Jenson, A. B. (1971) Epithelial and myoepithelial oncocytes. Ultrastructural study of a salivary gland oncocytoma. Archives of Otolaryngology, 93: 46–54.CrossRefGoogle ScholarPubMed
Bauer, W. H., Bauer, J. D. (1953) Classification of glandular tumours of salivary glands. Study of 143 cases. Archives of Pathology, 55: 328–346.Google Scholar
Blanck, C.Eneroth, C. -M., Jakobsson, P. A. (1970) Oncocytoma of the parotid gland. Neoplasm or nodular hyperplasia? Cancer, 25: 919–925.3.0.CO;2-7>CrossRefGoogle ScholarPubMed
Buxton, R. W., Maxwell, J. H., French, A. J. (1953) Surgical treatment of epithelial tumours of the parotid gland. Surgery, Gynecology and Obstetrics, 97: 401–416.Google ScholarPubMed
Caselitz, J., Schulze, I., Seifert, G. (1986) Adenoid cystic carcinoma of the salivary glands. An immunohistochemical study. Journal of Oral Pathology, 15: 308–318.CrossRefGoogle ScholarPubMed
Eneroth, C. M. (1965) Oncocytoma of major salivary glands. Journal of Laryngology and Otology, 79: 1064–1072.CrossRefGoogle ScholarPubMed
Fayemi, A. O., Toker, C. (1974) Malignant oncocytoma of the parotid gland. Archives of Otolaryngology, 99: 375–376.CrossRefGoogle ScholarPubMed
Feiner, H. D., Goldstein, S., Ittman, M., Pelton, K., Jacobs, J. (1986) Oncocytic adenoma of the parotid gland with psammoma bodies. Archives of Pathology and Laboratory Medicine, 110: 640–644.Google ScholarPubMed
Ghandur-Mnaymneh, L. (1984) Multinodular oncocytoma of the parotid gland. A benign lesion simulating malignancy. Human Pathology, 15: 485–486.CrossRefGoogle ScholarPubMed
Gray, S. R., Cornog, J. L. Jr., Seo, I. S. (1976) Oncocytic neoplasms of salivary glands. A report of 15 cases including two malignant oncocytomas. Cancer, 38: 1306–1317.3.0.CO;2-A>CrossRefGoogle Scholar
Hsu, S. -M., Raine, L., Fanger, H. (1981) Use of avidin-biotinperoxidase complex (ABC) in immunoperoxidase techniques. A comparison between ABC and unlabelled antibody (PAP) procedures. Journal of Histochemistry and Cytochemistry, 29: 577–580.CrossRefGoogle Scholar
Jensen, M. L. (1989) Multifocal adenomatous oncocytic hyperplasia in parotid glands with metastatic deposits or primary malignant transformation? Pathology, Research and Practice, 185: 514–521.CrossRefGoogle Scholar
Johns, M. E., Batsakis, J. G., Short, C. D. (1973) Oncocytic and oncocytoid tumours of the salivary glands. Laryngoscope, 83: 1940–1952.CrossRefGoogle ScholarPubMed
Johns, M. E., Regezi, J. A., Batsakis, J. G. (1977) Oncocytic neoplasms of salivary glands. An ultrastructural study. Laryngoscope, 87: 862–871.CrossRefGoogle ScholarPubMed
Laurian, N., Zohar, Y., Kende, L. (1977) Malignant oncocytoma. Journal of Laryngology and Otology, 91: 805–808.CrossRefGoogle ScholarPubMed
Lee, S. C., Roth, L. M. (1976) Malignant oncocytoma of the parotid gland. A light and electron microscopic study. Cancer, 37: 1607–1614.3.0.CO;2-R>CrossRefGoogle ScholarPubMed
Leventon, G., Katz, D. R., Bell, C. D. (1976) Malignant oncocytic tumour of the parotid salivary gland. Journal of Laryngology and Otology, 90: 289–293.CrossRefGoogle ScholarPubMed
Mair, I. W. S., Johannessen, T. A. (1972) Benign and malignant oncocytoma of the parotid gland. Laryngoscope, 82: 638–642.CrossRefGoogle ScholarPubMed
Murase, N., Kobayashi, K., Mitani, H., Mori, M. (1985) Immunohistochemical localization of α-antitrypsin and αl-antichymotrypsin in salivary pleomorphic adenomas. Virchows Archiv A, 408: 107–116.CrossRefGoogle Scholar
Ross, C. F. (1976) Malignant oncocytoma (‘oxyphilic granular-cell tumour’) of parotid gland. Clinical Oncology, 2: 253–260.Google ScholarPubMed
Schwartz, I. S., Feldman, M. (1969) Diffuse multinodular oncocytoma (‘oncocytosis’) of the parotid gland. Cancer, 23: 636–640.3.0.CO;2-0>CrossRefGoogle ScholarPubMed
Sehested, M., Barfoed, C.Krogdahl, A., Bretlau, P. (1985) Immunohistochemical investigation of lysozyme, lactoferrin, αl-antitrypsin, α1-antichymotrypsin and ferritin in parotid gland tumours. Journal of Oral Pathology, 14: 459–465.CrossRefGoogle Scholar
SØrensen, M., Baunsgaard, P., Frederiksen, P., Haahr, P. A. (1986) Multifocal adenomatous oncocytic hyperplasia of the parotid gland. Unusual clear cell variant in two female siblings. Pathology, Research and Practice, 181: 254–257.CrossRefGoogle ScholarPubMed
Stead, R. H., Qizilbash, A. H., Kontozoglou, T., Daya, A. D., Riddell, R. H. (1988) An immunohistochemical study of pleomorphic adenomas of the salivary gland. Glial fibrillary acidic protein-like immunoreactivity identifies a major myoepithelial component. Human Pathology, 19: 32–40.CrossRefGoogle Scholar
Tandler, B. (1966) Fine structure of oncocytes in human salivary glands. Virchows Archiv A, 341: 317–326.CrossRefGoogle ScholarPubMed
Whittam, D. E., Bose, B. (1971) Malignant oncocytoma of the parotid gland. British Journal of Surgery, 58: 851–853.CrossRefGoogle ScholarPubMed