Hostname: page-component-6766d58669-76mfw Total loading time: 0 Render date: 2026-05-21T14:52:06.911Z Has data issue: false hasContentIssue false
  • English
  • Français

Metastatic cutaneous squamous cell carcinoma of the parotid gland: prognostic factors

Published online by Cambridge University Press:  05 July 2017

A C Coombs ,
A Butler  and
R Allison
A C Coombs*
Affiliation:
Department of Otolaryngology Head and Neck Surgery, Dunedin Hospital, New Zealand
A Butler
Affiliation:
Department of Otolaryngology Head and Neck Surgery, Christchurch Hospital, New Zealand
R Allison
Affiliation:
Department of Otolaryngology Head and Neck Surgery, Christchurch Hospital, New Zealand
*
Address for correspondence: Dr Alice C Coombs, Department of Otolaryngology Head and Neck Surgery, Dunedin Hospital, 201 Great King Street, Dunedin 9016, New Zealand Fax: +64 (0)3 470 9959 E-mail: alice.coombs@southerndhb.govt.nz
Get access Rights & Permissions [Opens in a new window]

Abstract

Background:

Metastatic cutaneous squamous cell carcinoma is the most common parotid malignancy in Australasia. Prognostic indicators are not clearly defined and the extent of surgical resection required is controversial.

Methods:

A retrospective analysis was conducted of 63 patients who underwent surgery for metastatic cutaneous squamous cell carcinoma of the parotid gland at a tertiary hospital over a 10-year period.

Results:

The five-year overall survival rate was 53 per cent, the disease-specific survival rate was 78 per cent and the locoregional control rate was 72 per cent. Immunosuppression and no adjuvant radiotherapy were associated with a significant reduction in disease-specific survival. None of the factors analysed had a significant effect on locoregional control rates.

Conclusion:

More extensive surgery, including lateral temporal bone resection, may improve local control rates in cases of more advanced disease. The reduced survival of immunocompromised patients must be considered when planning their management.

Keywords

Skin NeoplasmsSquamous Cell CarcinomaMetastasisParotid GlandPrognosis

Information

Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 132 , Issue 3 , March 2018 , pp. 264 - 269
Copyright
Copyright © JLO (1984) Limited 2017 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

Article purchase

Temporarily unavailable

Footnotes

Presented as a poster at the New Zealand Society of Otolaryngology, Head and Neck Surgery 69th Annual General and Scientific Meeting, 16–19 October 2016, Christchurch, New Zealand.

References

1 O'Hara, J, Ferlito, A, Takes, RP, Rinaldo, AR, Strojan, P, Shaha, AR et al. Cutaneous squamous cell carcinoma of the head and neck metastasizing to the parotid gland – a review of current recommendations. Head Neck 2011;33:1789–95CrossRefGoogle Scholar
2 O'Brien, CJ, McNeil, EB, McMahon, JD, Pathak, I, Lauer, CS, Jackson, MA. Significance of clinical stage, extent of surgery, and pathologic findings in metastatic cutaneous squamous carcinoma of the parotid gland. Head Neck 2002;24:417–22Google Scholar
3 Veness, MJ, Palme, CE, Morgan, GJ. High-risk cutaneous squamous cell carcinoma of the head and neck: results from 266 treated patients with metastatic lymph node disease. Cancer 2006;106:2389–96Google Scholar
4 Veness, MJ, Morgan, GJ, Palme, CE, Gebski, V. Surgery and adjuvant radiotherapy in patients with cutaneous head and neck squamous cell carcinoma metastatic to lymph nodes: combined treatment should be considered best practice. Laryngoscope 2005;115:870–5Google Scholar
5 Moore, BA, Weber, RS, Prieto, V, El-Naggar, A, Holsinger, FC, Zhou, X et al. Lymph node metastases from cutaneous squamous cell carcinoma of the head and neck. Laryngoscope 2005;115:1561–7CrossRefGoogle ScholarPubMed
6 Shao, A, Wong, DK, McIvor, NP, Mylnarek, AM, Chaplin, JM, Izzard, ME et al. Parotid metastatic disease from cutaneous squamous cell carcinoma: prognostic role of facial nerve sacrifice, lateral temporal bone resection, immune status and P-stage. Head Neck 2014;35:545–50Google Scholar
7 Bova, R, Saylor, A, Coman, WB. Parotidectomy: review of treatment and outcomes. ANZ J Surg 2004;74:563–8Google Scholar
8 Gidley, PW, Thompson, CR, Roberts, DB, Weber, RS. The results of temporal bone surgery for advanced or recurrent tumors of the parotid gland. Laryngoscope 2011;121:1702–7CrossRefGoogle ScholarPubMed
9 O'Connor, A, Behan, L, Toner, M, Kinsella, J, Beausang, E, Timon, C. Evaluating the outcomes of temporal bone resection in metastatic cutaneous head and neck malignancies: 13-year review. J Laryngol Otol 2015;129:964–9Google Scholar
10 Chen, MM, Roman, SA, Sosa, JA, Judson, BL. Prognostic factors for squamous cell cancer of the parotid gland: an analysis of 2104 patients. Head Neck 2015;37:1–7 CrossRefGoogle ScholarPubMed
11 Khurana, VG, Mentis, DH, O'Brien, CJ, Hurst, TL, Stevens, GN, Packham, NA. Parotid and neck metastases from cutaneous squamous cell carcinoma of the head and neck. Am J Surg 1995;170:446–50Google Scholar
12 Ch'ng, S, Maitra, A, Lea, R, Brasch, H, Tan, ST. Parotid metastasis – an independent prognostic factor for head and neck cutaneous squamous cell carcinoma. J Plast Reconstr Aesthet Surg 2006;59:1288–93CrossRefGoogle ScholarPubMed
13 Palme, CE, O'Brien, CJ, Veness, MJ, McNeil, EB, Bron, LP, Morgan, GJ. Extent of parotid disease influences outcome in patients with metastatic cutaneous squamous cell carcinoma. Arch Otolaryngol Head Neck Surg 2003;129:750–3Google Scholar
14 Oddone, A, Morgan, GJ, Palme, CE, Perera, L, Shannon, J, Wong, E et al. Metastatic cutaneous squamous cell carcinoma of the head and neck. Cancer 2009;115:1883–91Google Scholar
15 Audet, NN, Palme, CE, Gullane, PJ, Gilbert, RW, Brown, DH, Irish, J et al. Cutaneous metastatic squamous cell carcinoma to the parotid gland: analysis and outcome. Head Neck 2004;26:727–32CrossRefGoogle Scholar
16 Hinerman, RW, Indelicato, DJ, Amdur, RJ, Morris, CG, Werning, JW, Vaysberg, M et al. Cutaneous squamous cell carcinoma metastatic to parotid-area lymph nodes. Laryngoscope 2008;118:1989–96Google Scholar
17 Chua, MS, Veness, MJ, Morgan, G, Shakespeare, T, Hehir, A, Gebski, V et al. Parotid lymph-node metastases from cutaneous squamous-cell carcinomas: treatment outcome and prognostic factors following surgery and adjuvant radiotherapy. Australas Radiol 2002;46:174–9Google Scholar
18 Dona, E, Veness, MJ, Cakir, B, Morgan, GJ. Metastatic cutaneous squamous cell carcinoma to the parotid: the role of surgery and adjuvant radiotherapy to achieve best outcome. ANZ J Surg 2003;73:692–6Google Scholar
19 Bron, LP, Traynor, SJ, McNeil, EB, O'Brien, CJ. Primary and metastatic cancer of the parotid: comparison of clinical behaviour in 232 cases. Laryngoscope 2003;113:1070–5Google Scholar
20 Andruchow, JL, Veness, MJ, Morgan, GJ, Gao, K, Clifford, A, Shannon, KF et al. Implications for clinical staging of metastatic cutaneous squamous carcinoma of the head and neck based on a multicenter study of treatment outcomes. Cancer 2006;106:1078–83CrossRefGoogle ScholarPubMed
21 Ch'ng, S, Maitra, A, Allison, RS, Chaplin, JM, Gregor, RT, Lea, R et al. Parotid and cervical nodal status predict prognosis for patients with head and neck metastatic cutaneous squamous cell carcinoma. J Surg Oncol 2008;98:101–5CrossRefGoogle ScholarPubMed
22 Makki, FM, Mendez, AI, Taylor, SM, Trites, J, Bullock, M, Flowerdew, G et al. Prognostic factors for metastatic cutaneous squamous cell carcinoma of the parotid. J Otolaryngol Head Neck Surg 2013;42:14–21 CrossRefGoogle ScholarPubMed
23 Southwell, KE, Chaplin, JM, Eisenberg, RL, McIvor, NP, Morton, RP. Effect of immunocompromise on metastatic cutaneous squamous cell carcinoma in the parotid and neck. Head Neck 2006;28:244–8Google Scholar
24 Sweeny, L, Zimmerman, T, Carroll, WR, Schmalbach, CE, Day, KE, Rosenthal, EL. Head and neck cutaneous squamous cell carcinoma requiring parotidectomy: prognostic indicators and treatment selection. Otolaryngol Head Neck Surg 2014;150:610–17Google Scholar
25 Ying, YM, Johnson, JT, Myers, EN. Squamous cell carcinoma of the parotid gland. Head Neck 2006;28:626–32Google Scholar