Hostname: page-component-77f85d65b8-9nbrm Total loading time: 0 Render date: 2026-03-28T00:42:05.942Z Has data issue: false hasContentIssue false
  • English
  • Français

Batroxobin can improve the efficacy of combination therapy for profound sudden sensorineural hearing loss greater than but not less than 100 dB HL

Published online by Cambridge University Press:  31 August 2023

Li Zhu Jiang  and
Wen Qi Zuo Open the ORCID record for Wen Qi Zuo [Opens in a new window]
Li Zhu Jiang
Affiliation:
Department of Otolaryngology, First Affiliated Hospital of Chongqing Medical University, Chongqing, People's Republic of China
Wen Qi Zuo*
Affiliation:
Department of Otolaryngology, First Affiliated Hospital of Chongqing Medical University, Chongqing, People's Republic of China
*
Corresponding author: Wen Qi Zuo; Email: zuowenqi2023@sina.com
Get access Rights & Permissions [Opens in a new window]

Abstract

Objective

To investigate the effects of combination therapy with and without batroxobin, and the frequency of batroxobin use on the prognosis of profound sudden sensorineural hearing loss.

Methods

Hearing recovery in the batroxobin group (231 patients) and non-batroxobin group (56 patients) was compared. The correlation between the number of times batroxobin was used and hearing recovery was analysed.

Results

The decrease in hearing threshold and overall improvement rate in the batroxobin group with hearing loss exceeding 100 dB HL was significantly higher than that in the non-batroxobin group. There was no linear correlation between the number of times batroxobin was used and the overall improvement rate. Using batroxobin two to three times achieved a therapeutic effectiveness plateau.

Conclusion

Batroxobin can improve the efficacy of combination therapy for profound sudden sensorineural hearing loss exceeding 100 dB HL, and using batroxobin two to three times yields the maximum overall improvement rate.

Keywords

Batroxobinsudden deafnesssensorineural hearing losstherapyprognosis

Information

Type
Main Article
Information
The Journal of Laryngology & Otology , Volume 138 , Issue 3 , March 2024 , pp. 270 - 275
Copyright
Copyright © The Author(s), 2023. Published by Cambridge University Press on behalf of J.L.O. (1984) LIMITED

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

Article purchase

Temporarily unavailable

Footnotes

Li Zhu Jiang takes responsibility for the integrity of the content of the paper

References

Chandrasekhar, SS, Tsai Do, BS, Schwartz, SR, Bontempo, LJ, Faucett, EA, Finestone, SA et al. Clinical Practice Guideline: sudden hearing loss (update). Otolaryngol Head Neck Surg 2019;161:S1–45Google Scholar
Editorial Board of Chinese Journal of Otorhinolaryngology Head and Neck Surgery; Society of Otorhinolaryngology Head and Neck Surgery, Chinese Medical Association. Guideline of diagnosis and treatment of sudden deafness (2015) [in Chinese]. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2015;50:443–7Google Scholar
Chinese sudden hearing loss multi-center clinical study group. Prospective clinical multi-center study on the treatment of sudden deafness with different typings in China [in Chinese]. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2013;48:355–61Google Scholar
Zheng, H, Dai, QQ, Zhou, L, Feng, NY, Qiu, JH, Chen, Y et al. Multi-center study on the treatment of sudden total deafness [in Chinese]. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2013;48:379–84Google Scholar
Fusconi, M, Chistolini, A, de Virgilio, A, Greco, A, Massaro, F, Turchetta, R et al. Sudden sensorineural hearing loss: a vascular cause? Analysis of prothrombotic risk factors in head and neck. Int J Audiol 2012;51:800–5CrossRefGoogle ScholarPubMed
Passamonti, SM, Di Berardino, F, Bucciarelli, P, Berto, V, Artoni, A, Gianniello, F et al. Risk factors for idiopathic sudden sensorineural hearing loss and their association with clinical outcome. Thromb Res 2015;135:508–12CrossRefGoogle ScholarPubMed
Perlman, HB, Kimura, R. Experimental obstruction of venous drainage and arterial supply of the inner ear. Ann Otol Rhinol Laryngol 1957;66:537–46CrossRefGoogle ScholarPubMed
Zhang, L, Lu, SH, Li, L, Tao, YG, Wan, YL, Senga, H et al. Batroxobin mobilizes circulating endothelial progenitor cells in patients with deep vein thrombosis. Clin Appl Thromb Hemost 2011;17:75–9CrossRefGoogle Scholar
Qin, J, Xu, Z, Shi, D, Chen, D, Dai, J, Teng, H et al. Deep vein thrombosis after total hip arthroplasty and total knee arthroplasty in patients with previous ischemic stroke. Int J Low Extrem Wounds 2013;12:316–19CrossRefGoogle ScholarPubMed
Xu, G, Liu, X, Zhu, W, Yin, Q, Zhang, R, Fan, X. Feasibility of treating hyperfibrinogenemia with intermittently administered batroxobin in patients with ischemic stroke/transient ischemic attack for secondary prevention. Blood Coagul Fibrinolysis 2007;18:193–7CrossRefGoogle ScholarPubMed
Oya, R, Horii, A, Akazawa, H, Osaki, Y, Inohara, H. Prognostic predictors of sudden sensorineural hearing loss in defibrinogenation therapy. Acta Otolaryngol 2016;136:271–6CrossRefGoogle ScholarPubMed
Kubo, T, Matsunaga, T, Asai, H, Kawamoto, K, Kusakari, J, Nomura, Y et al. Efficacy of defibrinogenation and steroid therapies on sudden deafness. Arch Otolaryngol Head Neck Surg 1988;114:649–52CrossRefGoogle ScholarPubMed
Shiraishi, T, Kubo, T, Okumura, S, Naramura, H, Nishimura, M, Okusa, M et al. Hearing recovery in sudden deafness patients using a modified defibrinogenation therapy. Acta Otolaryngol Suppl 1993;501:46–50CrossRefGoogle ScholarPubMed
Suzuki, H, Furukawa, M, Kumagai, M, Takahashi, E, Matsuura, K, Katori, Y et al. Defibrinogenation therapy for idiopathic sudden sensorineural hearing loss in comparison with high-dose steroid therapy. Acta Otolaryngol 2003;123:46–50CrossRefGoogle ScholarPubMed
Michel, O. The revised version of the German guidelines ‘Sudden idiopathic sensorineural hearing loss’ [in German]. Laryngorhinootologie 2011;90:290–3CrossRefGoogle ScholarPubMed
Nakashima, T, Naganawa, S, Sone, M, Tominaga, M, Hayashi, H, Yamamoto, H et al. Disorders of cochlear blood flow. Brain Res Brain Res Rev 2003;43:17–28CrossRefGoogle ScholarPubMed
Shi, X. Physiopathology of the cochlear microcirculation. Hear Res 2011;282:10–24CrossRefGoogle ScholarPubMed
Kawakami, M, Makimoto, K, Yamamoto, H, Takahashi, H. The effect of batroxobin on cochlear blood flow. Acta Otolaryngol 1992;112:991–7CrossRefGoogle ScholarPubMed
Ding, J, Zhou, D, Hu, Y, Elmadhoun, O, Pan, L, Ya, J et al. The efficacy and safety of batroxobin in combination with anticoagulation on cerebral venous sinus thrombosis. J Thromb Thrombolysis 2018;46:371–8CrossRefGoogle ScholarPubMed
Carr, ME Jr, Carr, SL, Tildon, T, Fisher, LM, Martin, EJ. Batroxobin-induced clots exhibit delayed and reduced platelet contractile force in some patients with clotting factor deficiencies. J Thromb Haemost 2003;1:243–9CrossRefGoogle ScholarPubMed