Hostname: page-component-76d6cb85b7-pn7tm Total loading time: 0 Render date: 2026-07-20T15:04:36.072Z Has data issue: false hasContentIssue false
  • English
  • Français

Clindamycin in treatment of chronic recurrent suppurative otitis media in children

Published online by Cambridge University Press:  29 June 2007

Itzhak Brook
Itzhak Brook
Affiliation:
Reprint address: I.Brook, M.Sc., M.D., Assistant Professor of Child Health and Development, George Washington University Medical School, Clinical Microbiology Laboratory and Infectious Diseases, Children's Hospital National Medical Center, 111 Michigan Avenue, N.W., Washington, D.C. 20010.
Get access Rights & Permissions [Opens in a new window]

Abstract

Tympanocentesis was performed in 28 pediatric patients with chronic recurrent suppurative otitis media. The purulent aspirate was cultured aerobically and anaerobically. Aerobes only were isolated from 4(14·3 per cent) patients; five (17·9 per cent) had only anaerobes and 19 (67·8 per cent) had both aerobes and anaerobes. There were 36 aerobic isolates. P. aeruginosa was recovered in 16 patients. Other aerobes commonly recovered included Proteus sp. and S. aureus. There were 38 anaerobes isolated. Anaerobic Gram-positive cocci were isolated in 23 instances. Eleven Bacteroides sp. were recovered, including 4 B. fragilis group and 5 B. melaninogenicus. All of the patients were treated with clindamycin in a dose of 30 to 40 mg per kilogram per day divided into 3 dosages for a total period of 14 to 21 days (average 17 days). When Gram-negative enteric aerobic rods were also recovered in substantial numbers, an aminoglycoside (gentamicin) was added to the therapy (in 12 patients) and administered parenterally for 7 to 10 days. The patients' response to the therapy was excellent in 7 cases, good in 9, fair in 3 and poor in 9. There were no diarrhea episodes or colitis noted and there were no other sideeffects due to the therapy. The above findings demonstrate the polymicrobial etiology of chronic recurrent suppurative otitis media and suggest that medical treatment directed against the aerobic and anaerobic bacteria isolated from the patients' ear aspirates could eradicate the infection completely in more than half of the cases.

Information

Type
Research Article
Information
The Journal of Laryngology & Otology , Volume 94 , Issue 6 , June 1980 , pp. 607 - 615
Copyright
Copyright © JLO (1984) Limited 1980

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

Article purchase

Temporarily unavailable

References

BIBLIOGRAPHY

Bartlett, J. B., and Gorbach, S. L. (1975) Treatment of Aspiration Pneumonia and Primary Lung Abscess. Penicillin G. vs. Clindamycin. Journal of the American Medical Association, 234, 935–937.Google Scholar
Brook, I., and Finegold, S. M. (1979) Bacteriology of Chronic Otitis Media. Journal of the American Medical Association, 241, 487–488.CrossRefGoogle ScholarPubMed
Chow, A. W., Montogmerie, J. A., and Guze, L. B. (1974) Parenteral Clindamycin Therapy for Severe Anaerobic Infections. Archives of Internal Medicine, 134, 78–82.CrossRefGoogle ScholarPubMed
Cohen, L. F., Mcneil, C. J., and Wells, R. F. (1973) Clindamycin Associated Colitis. Journal of the American Medical Association, 223, 1379–1380.CrossRefGoogle ScholarPubMed
Elmore, M. F., Rink, L. D., and Rissing, J. P. (1973) Clindamycin, Endocarditis, Hepatotoxicity. Annals of Internal Medicine, 78, 779–780.CrossRefGoogle ScholarPubMed
Finegold, S. M. (1977) Anaerobic Bacteria in Human Disease. Academic Press, New York, N. Y.Google Scholar
Gorbach, S. L., and Thadepalli, H. (1974) Clindamycin in the Treatment of Pure and Mixed Anaerobic Infections. Archives of Internal Medicine, 134, 87–92.Google Scholar
Jokipii, A. M. M., Karma, P., Ojala, K., and JoKipii, L. (1977) Anaerobic Bacteria in Chronic Otitis Media. Archives of Otolaryngology, 103, 278–280.CrossRefGoogle ScholarPubMed
Jordan, R. (1949) Chronic Secretary Otitis Media. Laryngoscope, 59, 1002–1015.Google Scholar
Liu, Y. S., Lim, D. J., Lang, R., and Birck, H. G. (1976) Microorganisms in Chronic Otitis Media with Effusion. Annals of Otology, Rhinology and Laryngology, 85, 245–249.CrossRefGoogle ScholarPubMed
Mawson, S. R. (1975) Diseases of the Ear. William and Wilkins Company, Baltimore, Third Edition.Google Scholar
Randolph, M. F., and Morris, K. E. (1977) Clindamycin Associated Colitis in Children: A prospective study and a negative report. Clinical Pediatrics, 16, 772–725.Google Scholar
Rodriquez, W., Ross, S., Khan, W., McKay, D., and Moskowitz, P. (1977) Clindamycin in Treatment of Osteomylitis in Children. A report of 29 cases. American Journal of Diseases of Childhood, 131, 1088–1093.Google Scholar
Senturia, B. H., Gessert, C. F., and Carr, C. D. (1958) Studies Concerned with Tubotympanitis. Annals of Otology, Rhinology and Laryngology, 67, 440–467.CrossRefGoogle ScholarPubMed
Sutter, V. L., Vargo, V. L., and Finegold, S. M. (1975) Wadsworth Anaerobic Bacteriology Manual. 2nd edition. Publ. University of California, Los Angeles, Extension Division.Google Scholar