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Kikuchi's disease of the neck (histiocytic necrotizing lymphadenitis)

Published online by Cambridge University Press:  29 June 2007

N. A. Bhat ,
Ye Lim Hock ,
N. O. Turner  and
A. R. Das Gupta
N. A. Bhat*
Affiliation:
Department of Otolaryngology, Manor Hospital, Walsall, UK.
Ye Lim Hock
Affiliation:
Department of Pathology, Manor Hospital, Walsall, UK.
N. O. Turner
Affiliation:
Department of Otolaryngology, Manor Hospital, Walsall, UK.
A. R. Das Gupta
Affiliation:
Department of Otolaryngology, Manor Hospital, Walsall, UK.
*
Address for correspondence: Mr N. A. Bhat, 14 Malcolmson Close, Edgbaston, Birmingham B15 3LS.
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Abstract

Histocytic necrotizing lymphadenitis (HNL), also known as Kikuchi's disease is a benign self limiting disease of unknown origin. It effects cervical lymph nodes, predominantly in young females. It is well described in the pathology literature, but little is written about this in the ENT literature, as few clinicians are probably aware of this condition. Five cases of cervical Kikuchi's disease are presented with a brief review of the literature.

Keywords

Lymphadenitis, histiocytic necrotizingLymph nodesNeckCytology

Information

Type
Pathology in Focus
Information
The Journal of Laryngology & Otology , Volume 112 , Issue 9 , September 1998 , pp. 898 - 900
Copyright
Copyright © JLO (1984) Limited 1998

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References

Ali, M. H., Horton, L. W. L. (1985) Necrotising lymphadenitis without granulocytic infiltration (Kikuchi's disease). Journal of Clinical Pathology 38: 1252–1257.CrossRefGoogle ScholarPubMed
Chamulak, G. A., Brynes, R. K., Nathwani, B. N. (1990) Kikuchi-Fujimoto disease mimicking malignant lymphoma. American Journal of Surgical Pathology 14: 514–523.CrossRefGoogle ScholarPubMed
Chan, J. K. C., Wong, K. C., Ng, C. S. (1989) A fatal case of multicentric Kikuchi's histiocytic necrotising lymphadenitis. Cancer 63: 1856–1862.3.0.CO;2-#>CrossRefGoogle Scholar
Dorfman, R. F. (1987) Histiocytic necrotising lymphadenitis of Kikuchi and Fujimoto. Archives of Pathology and Laboratory Medicine 111: 1026–1029.Google ScholarPubMed
Dorfman, R. F., Berry, G. J. (1988) Kikuchi's histiocytic necrotising lymphadenitis: an analysis of 108 cases with emphasis on differential diagnosis. Seminars in Diagnostic Pathology 5: 329–345.Google ScholarPubMed
Fujimoto, Y., Kojima, Y., Yamaguchi, K. (1972) Cervical subacute necrotising lymphadenitis. A new clinico-pathological entity. Naika 30: 920–927 (in Japanese).Google Scholar
Gleeson, M. J., Siodlak, M. Z., Barbatis, C., Salama, N. Y. (1985) Kikuchi's – a new cause of cervical lymphadenopathy. Journal of Laryngology and Otology 99: 935–939.CrossRefGoogle Scholar
Heldenberg, D., Amar, M., Ben-Arie, Y., Iuchtman, M. (1996) Axillary involvement in paediatric Kikuchi's disease. European Journal of Paediatric Surgery 6(1): 32–34.CrossRefGoogle ScholarPubMed
Hsueh, E. J., Ko, W. S., Hwang, W. S., Yam, L. T. (1993) Fine needle aspiration of histiocytic necrotising lymphadenitis (Kikuchi's disease). Diagnostic Cytopathology 9: 448.CrossRefGoogle ScholarPubMed
Imamura, M., Ueno, H., Matsuura, A., Kamiya, H., Suzuki, T., Kikuchi, K., Onoe, T. (1982) An ultra structural study of subacute necrotising lymphadenitis. American Journal of Pathology 107: 292–299.Google Scholar
Kapadia, V., Robinson, B. A., Angus, H. B. (1989) Kikuchi's disease presenting as fever of unknown origin [Letter]. Lancet 2: 986.Google ScholarPubMed
Kikuchi, M. (1972) Lymphadenitis showing focal reticulum cell hyperplasia with nuclear debris and phagocytes: A clinico-pathological study. Acta Haematologia Japan 35: 379–380.Google Scholar
Kikuchi, M., Yoshizumi, T., Nakamura, H. (1977) Necrotising lymphadenitis: possible acute toxoplasmic infection. Virchows Archives (A) 376: 247–253.CrossRefGoogle ScholarPubMed
Kumar, B. N., Walsh, R. M., Walter, N. M., Little, J. T. (1997) Histiocytic necrotising lymphadenitis (Kikuchi's disease) of the cervical lymph nodes. Journal of Oto-Laryngology 59: 176–178.Google ScholarPubMed
Nathwani, B. M. (1991) Kikuchi-Fujimoto disease. American Journal of Surgical Pathology 15: 196–198.CrossRefGoogle Scholar
Nieman, R. B. (1990) Diagnosis of Kikuchi's disease. Lancet 335: 295.CrossRefGoogle ScholarPubMed
Pileri, S. A., Sabattini, E., Costigliola, P. (1991) Kikuchi's lymphadenitis and HIV infection. AIDS 5: 459–461.Google ScholarPubMed
Seno, A., Torigoe, R., Shimoe, K. (1994) Kikuchi's disease (histiocytic necrotising lymphadenitis) with cutaneous involvement. Journal of American Academy of Dermatology 30: 504–506.CrossRefGoogle ScholarPubMed
Sever, C. E., Leith, C. P., Appenzeller, J., Foucar, K. (1996) Kikuchi's histiocytic necrotising lymphadenitis associated with ruptured silicone breast implants. Archives of Pathology and Laboratory Medicine 120(4): 380–385.Google Scholar
Shih-Hua, L., Wang-Sheng, K., Herng-Sheng, L., Wei-Shou, H. (1992) Kikuchi's disease associated with lupus-like syndrome – a fatal case [Letter]. Journal of Rheumatology 19: 1995–1996.Google Scholar
Smith, K. G. C., Becker, G. J., Busmanis, I. (1992) Recurrent Kikuchi's disease [Letter]. Lancet 340: 124.CrossRefGoogle ScholarPubMed
Sumiyoshi, Y., Kikuchi, M., Minematu, T. (1994) Analysis of herpes virus genomes in Kikuchi's disease. Virchows Archives 424: 437–440.CrossRefGoogle ScholarPubMed