Hostname: page-component-76d6cb85b7-hqrjx Total loading time: 0 Render date: 2026-07-27T12:56:51.480Z Has data issue: false hasContentIssue false
  • English
  • Français

Assessment of prestin level changes as an inner-ear biomarker in patients with idiopathic sudden sensorineural hearing loss

Published online by Cambridge University Press:  22 October 2021

F Saadat ,
M M Jalali Open the ORCID record for M M Jalali [Opens in a new window]  and
M Akbari
F Saadat
Affiliation:
Department of Immunology, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran
M M Jalali*
Affiliation:
Otorhinolaryngology Research Center, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran
M Akbari
Affiliation:
Otorhinolaryngology Research Center, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran
*
Author for correspondence: Prof Mir Mohammad Jalali, Otorhinolaryngology Research Center, Amiralmomenin Hospital, Rasht 4193875197, Iran E-mail: mmjalali@gmail.com
Get access Rights & Permissions [Opens in a new window]

Abstract

Objective

To assess the correlation of serum prestin level and audiological findings in adults with idiopathic sudden sensorineural hearing loss.

Methods

Audiometry and serum prestin measurements were performed at study entry (T0), at day 14 (end of treatment, T1) and at day 30 (T2).

Results

A total of 25 idiopathic sudden sensorineural hearing loss patients and 25 healthy adults were included. The geometric mean prestin level in the case and control groups at T0 was 227.7 pg/ml and 130.5 pg/ml, respectively. The geometric mean prestin level in the case group demonstrated a downward trend at T1 and T2 (214.0 pg/ml and 180.1 pg/ml, respectively; p < 0.001). Of 17 patients with high baseline prestin levels (over 150 pg/ml), prestin levels tended to decrease in 11 patients, and 5 of them (45.5 per cent) showed good recovery.

Conclusion

The prestin concentrations increased in two-thirds of patients with idiopathic sudden sensorineural hearing loss. Future work is recommended to determine the location of injury.

Keywords

Sensorineural Hearing LossAudiometryPure-TonePrestinBiomarkers

Information

Type
Main Article
Information
The Journal of Laryngology & Otology , Volume 136 , Issue 11 , November 2022 , pp. 1039 - 1043
Copyright
Copyright © The Author(s), 2021. Published by Cambridge University Press on behalf of J.L.O. (1984) LIMITED

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

Article purchase

Temporarily unavailable

Footnotes

Prof M M Jalali takes responsibility for the integrity of the content of the paper

References

Tovi, H, Ovadia, H, Eliashar, R, de Jong, MA, Gross, M. Prestin autoantibodies screening in idiopathic sudden sensorineural hearing loss. Eur Ann Otorhinolaryngol Head Neck Dis 2019;136:99–101CrossRefGoogle ScholarPubMed
Chen, L, Zhang, G, Zhang, Z, Wang, Y, Hu, L, Wu, J. Neutrophil-to-lymphocyte ratio predicts diagnosis and prognosis of idiopathic sudden sensorineural hearing loss: a systematic review and meta-analysis. Medicine (Baltimore) 2018;97:e12492CrossRefGoogle ScholarPubMed
Li, G, You, D, Ma, J, Li, W, Li, H, Sun, S. The role of autoimmunity in the pathogenesis of sudden sensorineural hearing loss. Neural Plast 2018;2018:7691473CrossRefGoogle ScholarPubMed
Zheng, J, Shen, W, He, DZ, Long, KB, Madison, LD, Dallos, P. Prestin is the motor protein of cochlear outer hair cells. Nature 2000;405:149–55CrossRefGoogle ScholarPubMed
Parham, K. Prestin as a biochemical marker for early detection of acquired sensorineural hearing loss. Med Hypotheses 2015;85:130–3CrossRefGoogle ScholarPubMed
Naples, J, Cox, R, Bonaiuto, G, Parham, K. Prestin as an otologic biomarker of cisplatin ototoxicity in a guinea pig model. Otolaryngol Head Neck Surg 2018;158:541–6CrossRefGoogle Scholar
Parham, K, Dyhrfjeld-Johnsen, J. Outer hair cell molecular protein, prestin, as a serum biomarker for hearing loss: proof of concept. Otol Neurotol 2016;37:1217–22CrossRefGoogle ScholarPubMed
Sun, C, Xuan, X, Zhou, Z, Yuan, Y, Xue, F. A preliminary report on the investigation of prestin as a biomarker for idiopathic sudden sensorineural hearing loss. Ear Nose Throat J 2020;99:528–31CrossRefGoogle ScholarPubMed
Cheng, Y-F, Chu, Y-C, Tu, T-Y, Shiao, A-S, Wu, S-L, Liao, W-H. Modified Siegel's criteria for sudden sensorineural hearing loss: reporting recovery outcomes with matched pretreatment hearing grades. J Chin Med Assoc 2018;81:1008–12CrossRefGoogle ScholarPubMed
Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults. Executive Summary of the Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). JAMA 2001;285:2486–97CrossRefGoogle Scholar
Ishai, R, Kamakura, T, Nadol, JBJ. Abnormal tectorial membranes in sensorineural hearing loss: a human temporal bone study. Otol Neurotol 2019;40:e732–8CrossRefGoogle ScholarPubMed
Ungar, OJ, Handzel, O, Santos, F. Rate of spiral ganglion cell loss in idiopathic sudden sensorineural hearing loss. Otol Neurotol 2018;39:e944–9CrossRefGoogle ScholarPubMed
Kang, WS, Yang, CJ, Shim, M, Song, CI, Kim, TS, Lim, HW et al. Prognostic factors for recovery from sudden sensorineural hearing loss: a retrospective study. J Audiol Otol 2017;21:9–15CrossRefGoogle ScholarPubMed
Conlin, AE, Parnes, LS. Treatment of sudden sensorineural hearing loss: I. A systematic review. Arch Otolaryngol Head Neck Surg 2007;133:573–81CrossRefGoogle ScholarPubMed
Conlin, AE, Parnes, LS. Treatment of sudden sensorineural hearing loss: II. A meta-analysis. Arch Otolaryngol Head Neck Surg 2007;133:582–6CrossRefGoogle ScholarPubMed
Parham, K, Sohal, M, Petremann, M, Romanet, C, Broussy, A, Tran Van Ba, C et al. Noise-induced trauma produces a temporal pattern of change in blood levels of the outer hair cell biomarker prestin. Hear Res 2019;371:98–104CrossRefGoogle ScholarPubMed