Introduction
The anterior ethmoidal artery (AEA) is a critical anatomical structure in paranasal sinus surgery. Intra-operative injury can lead to heavy bleeding, orbital haematoma, visual compromise, cerebrospinal fluid leakage, and, rarely, intracranial haemorrhage, emphasising the need for precise identification and preservation of the vessel.Reference Naidu, Sibiya, Aladeyelu and Rennie1 Moreover, during an external rhinotomy for sinonasal tumour resection, locating the lacrimal crest and subsequently tracing the AEA along the frontoethmoidal suture line aids in delineating the skull base.Reference White, Sincoff and Abdulrauf2 The AEA is likewise used as a practical landmark to orient the frontal recess and frontal sinus or the anterior skull base during endoscopic sinus surgery, and in transcribriform approaches, it is typically identified and ligated preemptively.Reference El-Anwar, Khazbak, Eldib and Algazzar3
The artery’s relationship to the skull base, however, varies across individuals along its course from the orbit to the cribriform plate. In this context, three types are commonly described: type A, in which the artery runs within or immediately adjacent to the skull base; type B, in which it passes through a canal that protrudes below the skull base; and type C, in which it courses freely within the ethmoid sinus, separated from the skull base.Reference Lannoy-Penisson, Schultz, Riehm, Atallah, Veillon and Debry4 The configuration may also be asymmetric, with different types present on the right and left sides in the same patient.Reference Sağlam, Deniz, Turmak, Hattapoğlu, Akbudak and Tekinhatun5 Because the type C artery is suspended away from the skull base and exposed within the ethmoid cavity, it carries a higher risk of intra-operative injury and thus demands particular caution.Reference El-Anwar, Khazbak, Eldib and Algazzar3
Pre-operative identification of the AEA type and its course on imaging is thus important to reduce the risk of vascular injury and to facilitate a safer operation. Particularly paranasal sinus (PNS) computed tomography (CT), which renders bony anatomy with high fidelity, allows estimation of the AEA pathway on coronal images using two landmarks—the notch of the medial orbital wall and the anterior ethmoidal groove on the lateral lamella of the cribriform plate.Reference Souza, de Souza, Gregório and Ajzen6, Reference Gotwald, Menzler, Beauchamp, zur Nedden and Zinreich7 Nevertheless, delineation can be challenging when prior surgery distorted the anatomy, when the bony wall of the anterior ethmoidal canal is dehiscent or markedly thinned or when a mucocele, extensive polyposis or a tumour involving ethmoid sinus is present.Reference El-Anwar, Khazbak, Eldib and Algazzar3, Reference Kang, Kim, Nam and Seo8 Therefore, this study aimed to identify factors that predict the AEA type and position. Using 3D reconstruction of PNS CT, we quantified frontal and ethmoidal pneumatisation and examined their associations with AEA type and its distance from the skull base.
Materials and methods
Patients and study design
This study retrospectively analysed the PNS CT images of the patients. The study received approval from the Institutional Review Board of Uijeongbu St. Mary’s Hospital, the Catholic University of Korea, in 2024 (approval number UC24RISI0119), with the exemption of patient consent. Data of patients who have undertaken PNS CT between November and December of 2023 were initially extracted. Patients under 18 years of age, those with craniofacial anomaly, those with history of nose surgery or traumatic facial fractures and those with abnormal lesions in the sinonasal region detected in PNS CT were excluded.
Patients were categorised into three types according to the location of AEA in PNS CT (type A: AEA buried in the skull base; type B: protruding equal to or more than 1 mm from the skull base; type C: AEA located in the ethmoid sinus separately from the skull base) (Figure 1).Reference Lannoy-Penisson, Schultz, Riehm, Atallah, Veillon and Debry4, Reference Ko, Kim and Jung9 Clinical characteristics were compared among the three types. Multinomial logistic regression analysis was performed to adjust for potential confounders and determine independent factors affecting AEA location. Correlation analysis and partial correlation analysis were additionally utilised to identify the association between the AEA-skull base distance (DAS) and the other anatomical variables as well as between the height of cribriform plate lateral lamella (HLL) and the other variables.
Figure 1. Classification of anterior ethmoidal artery types according to their relationship to the skull base. (a) Type A: anterior ethmoidal artery buried in the skull base. (b) Type B: protruding equal to or greater than 1 mm from the skull base. (c) Type C: located in the ethmoid sinus separately from the skull base.
Measurement of length, area and volume parameters
When performing PNS CT, patients were positioned supine, and the angle of the hard palate was adjusted to be perpendicular to the scanning table of the CT device. Images were acquired with a 1-mm slice thickness. The frontal recess anterior cells (FRAC)—the anteriorly located cells within the frontal recess including the Agger nasi and supra-Agger cells per the International Frontal Sinus Anatomy Classification—were identified, and their height (HFRAC) was defined as the vertical distance from the lowest to the highest point (Figure 2A).Reference Wormald, Hoseman, Callejas, Weber, Kennedy and Citardi10 The frontal beak–AEA distance (DFA) was measured on the sagittal view containing the entry point of the AEA into the skull base, as the horizontal distance between the frontal beak and the AEA (Figure 2B). HLL was determined on coronal images at the point where the AEA entered the skull base and was defined as the vertical height of the lateral lamella; this value was then used to classify the Keros type (type I: < 4 mm; type II: ≥ 4 and < 8 mm; type III: ≥ 8 mm) (Figure 2C).Reference Keros11 The interzygomatic distance (WZ) was defined on the axial view at the highest level where the zygomatic arch meets the temporal bone, as the greatest distance between the right and left zygomas (Figure 2D). In addition, the nasion–sphenoid distance (DNS) was designated on the sagittal view including the nasion, as the horizontal distance from the anterior border of the nasal bone to the posterior-most point of sphenoid sinus posterior wall (Figure 2E). The DAS was defined as the vertical distance from the floor of the AEA canal at its midpoint to the inferior surface of the skull base at the corresponding site (Figure 2F).
Figure 2. Linear measurements on paranasal sinus computed tomography (CT). (a) Height of the frontal recess anterior cells (HFRAC). (b) Frontal beak–anterior ethmoidal artery distance (DFA). (c) Height of the cribriform plate lateral lamella (HLL). (d) Interzygomatic distance (WZ). (e) Nasion–sphenoid distance (DNS). (f) Anterior ethmoidal artery–skull base distance (DAS).
Volumes of 3D parameters were measured using V-works software (Version 4.0, Cybermed Inc., Seoul, South Korea). Surface renderings were generated using −318 Hounsfield units (HU) as the air–density threshold. To measure the frontal sinus volume (VFS), reference lines were drawn on PNS CT sagittal views containing the frontal recess, extending from the frontal ridge to the point where the septum separating the frontal and ethmoid sinuses meets the skull base; these lines were designated as the inferior boundary for the calculation of frontal sinus volume (Figure 3A). The volume of frontal recess anterior cells (VFRAC) was defined as the sum of the volumes of the Agger nasi cell and supra-Agger cells located in the anterior portion of the frontal recess (Figure 3B, 3C).
Figure 3. Volumetric measurements of frontal sinus and frontal recess anterior cells (FRAC) on paranasal sinus computed tomography (CT). (a) On each sagittal slice of paranasal sinus CT, a reference line (red line) was drawn from the frontal ridge to the point where the septum separating the frontal and ethmoid sinuses meets the skull base, serving as the inferior boundary of frontal sinus (blue shading). (b) Sagittal slice illustrating the FRAC (blue shading). (c) 3D reconstruction of frontal sinus volume (VFS), the volume of FRAC (VFRAC) and the frontal recess passage; frontal sinuses are shown in blue, FRAC in green and frontal recess passage in yellow.
Statistical analysis
All statistical analyses were carried out using IBM SPSS Statistics (version 28; IBM Corp., Armonk, NY, USA). Continuous data were expressed as mean values with corresponding standard deviations, whereas categorical data were summarised as frequencies and percentages. Comparisons of continuous variables across multiple groups were conducted using one-way analysis of variance followed by Tukey’s post hoc test or the Kruskal–Wallis test when appropriate. For categorical variables, group differences were assessed with Pearson’s χ2 test or Fisher’s exact test, applying Bonferroni correction for multiple comparisons. To adjust for potential confounders and to determine independent predictors of ternary outcomes, multinomial logistic regression models were employed. Correlations between continuous variables were examined using Spearman’s correlation analysis, and partial Spearman’s correlation was further applied to account for additional confounding variables. A two-tailed p value less than 0.05 was considered indicative of statistical significance.
Results and analysis
A total of 56 participants (112 nasal cavities) were finally included in this study. Average age was 45.1 ± 17.7 years, and of the total participants 29 (51.8 %) patients were male and 27 (48.2 %) were female.
Table 1 summarises the comparison of clinical characteristics among types A, B and C. A significant difference was observed in the distribution of sex across the three types, with the proportion of males being highest in type C and lowest in type A, showing a significant difference between types A and C (27.8 % vs. 64.6 %; p = 0.005). No significant difference was found in age. Both VFS and VFRAC demonstrated significant differences, with type C showing significantly greater values compared with types A and B (VFS: 1.66 ± 1.18 vs. 2.01 ± 2.11 vs. 4.34 ± 3.21 cm3; p < 0.001 for both; VFRAC: 108.40 ± 74.78 vs. 95.82 ± 66.23 vs. 189.59 ± 135.40 mm3; p = 0.003 and <0.001, respectively). HFRAC was also highest in type C, and a significant difference was noted between types B and C (1.20 ± 0.42 vs. 1.48 ± 0.51 cm; p = 0.030). In contrast, DFA did not differ significantly among the three types. The prevalence of supraorbital ethmoid cells (SOEC) was highest in type C, with a significant difference between types A and C (11.1 % vs. 41.5 %; p = 0.017). HLL and Keros type also revealed significant differences. HLL was significantly greater in type C than in types A and B (4.11 ± 1.61 vs. 4.16 ± 1.27 vs. 6.52 ± 2.79 mm; p < 0.001). The proportions of Keros type I and II were lowest in AEA type C, while Keros type III was most frequent in AEA type C, showing a significant difference compared with AEA types A and B. The presence of frontal cells did not differ significantly among the types. Likewise, WZ and the DNS showed no significant inter-type differences.
Table 1. Comparison of clinical findings among the AEA types
AEA = anterior ethmoidal artery; DFA = frontal beak–AEA distance; DNS = nasion–sphenoid distance; HFRAC = height of frontal recess anterior cells, HLL = lateral lamella height; SOEC = supraorbital ethmoid cell; VFRAC = volume of frontal recess anterior cells; VFS = frontal sinus volume; WZ = interzygomatic distance;
a Keros type: type I, a depth of the olfactory fossa < 4 mm; type II, a depth ≥ 4 and < 8 mm; type III, a depth ≥ 8 mm.
* Significant difference between types A vs. B.
† Significant difference between types B vs. C.
‡ Significant difference between types A vs. C.
The results of the multinomial logistic regression analysis, performed to control for potential confounding effects and to evaluate the independent influence of each CT parameter on AEA type, are presented in Table 2. Variables that demonstrated significant differences in the initial inter-type comparisons were included as independent variables. In the comparison between type A and type B the lack of significant associations between the CT parameters and AEA types remained unchanged after adjustment for confounders. In contrast, in the comparison between type B and type C, VFS, VFRAC and HLL remained significantly different, and higher values of each variable was associated with increased probability of belonging to type C (VFS: odds ratio [OR] 1.343, 95 % confidence interval [CI] 1.006–1.793; p = 0.045; VFRAC: OR 1.010, 95 % CI 1.001–1.019; p = 0.028; HLL: OR 1.877, 95 % CI 1.261–2.794; p = 0.002), whereas HFRAC lost its significance. Furthermore, in the comparison between type A and type C, HLL continued to show a significant association (OR 2.020; 95 % CI 1.270–3.212; p = 0.003), while sex, VFS, VFRAC and presence of SOEC were no longer significantly related to AEA types.
Table 2. Multinomial logistic regression analysis for identifying independent factors associated with AEA type
AEA = anterior ethmoidal artery; CI = confidence interval; HFRAC = height of frontal recess anterior cells; HLL = lateral lamella height; OR = odds ratio; SOEC = supraorbital ethmoid cell; VFRAC = volume of frontal recess anterior cells; VFS = frontal sinus volume.
a Continuous variables: odds ratio of belonging to the latter group per 1-unit increase. Categorical variables: odds ratio of belonging to the latter group for each category (e.g., male sex or presence of a supraorbital cell).
* p < 0.05.
The results of the correlation analysis between DAS values and the other continuous variables are presented in Table 3. Age and DFA showed no significant associations with DAS values. In contrast, VFS, VFRAC, HFRAC and HLL each demonstrated a significant positive correlation with DAS (VFS: Spearman correlation coefficient [rs] 0.401, p < 0.001; VFRAC: rs 0.436, p < 0.001; HFRAC: rs 0.269, p = 0.004; HLL: rs 0.604, p < 0.001). WZ and DNS were also positively correlated with DAS (Wz: rs 0.219, p = 0.020; DNS: rs 0.226, p = 0.016). Furthermore, in the partial correlation analysis controlling for the effects of age, WZ and DNS, the positive correlations between DAS and VFS, VFRAC, HFRAC and HLL remained significant respectively (VFS: rs 0.365, p < 0.001; VFRAC: rs 0.460, p < 0.001; HFRAC: rs 0.257, p = 0.007; HLL: rs 0.612, p < 0.001).
Table 3. Correlation analysis between AEA–skull base distance and the other continuous variables
AEA = anterior ethmoidal artery; VFS = frontal sinus volume; VFRAC = volume of frontal recess anterior cells; HFRAC = height of frontal recess anterior cells; DFA = frontal beak–AEA distance; HLL = lateral lamella height; WZ = interzygomatic distance; DNS = nasion–sphenoid distance; rs = Spearman correlation coefficient.
* p < 0.05.
The correlation analyses between the HLL and other continuous variables are summarised in Table 4. HLL was not significantly associated with age, DFA, WZ and DNS. In contrast, HLL demonstrated significant positive correlations with VFS, VFRAC, HFRAC and DAS (VFS: rs 0.285, p = 0.002; VFRAC: rs 0.264, p = 0.005; HFRAC: rs 0.218, p = 0.021; DAS: rs 0.604, p < 0.001).
Table 4. Correlation analysis between height of cribriform plate lateral lamella and the other continuous variables
DAS = anterior ethmoidal artery–skull base distance; DNS = nasion–sphenoid distance; DFA = frontal beak–anterior ethmoidal artery distance; HFRAC = height of frontal recess anterior cells; rs = Spearman correlation coefficient; VFRAC = volume of frontal recess anterior cells; VFS = frontal sinus volume; WZ = interzygomatic distance;
* p < 0.05.
Discussion
In endoscopic sinus surgery, AEA is a critical surgical landmark. Anatomically, the AEA branches from the ophthalmic artery, itself a division of the internal carotid artery. Within the orbit, it courses between the superior oblique and medial rectus muscles before traversing the anterior ethmoidal foramen of the medial orbital wall. It then proceeds through the anterior ethmoidal canal along the ethmoid sinus or ethmoid roof, typically running obliquely in an anteromedial direction, and enters the anterior cranial fossa via the lateral lamella of the cribriform plate. The AEA supplies the frontal and ethmoid sinuses, the nasal roof and septum and the meninges of the anterior cranial fossa.Reference Naidu, Sibiya, Aladeyelu and Rennie1, Reference Moon, Kim, Lee, Chung and Yoon12, Reference Szczepanek, Toppich, Ostrowski, Bonczar, Nasser and Dziedzic13 The AEA is usually grouped into three categories by its position relative to the skull base, with substantial variation among patients.Reference Lannoy-Penisson, Schultz, Riehm, Atallah, Veillon and Debry4 However, data are still limited on which clinical features are associated with each type.
In our cohort, the distribution of AEA types was 16.1 % for type A, 25.9 % for type B and 58.0 % for type C. This profile contrasts with earlier reports in which the artery was most frequently embedded within the skull base.Reference Lannoy-Penisson, Schultz, Riehm, Atallah, Veillon and Debry4, Reference Moon, Kim, Lee, Chung and Yoon12, Reference Abdullah, Lim, Mohamad, Husain, Aziz and Snidvongs14–Reference Simmen, Raghavan, Briner, Manestar, Schuknecht and Groscurth16 However, studies mirroring our findings—showing a predominance of type C—have also been published.Reference Cankal, Apaydin, Acar, Elhan, Tekdemir and Yurdakul17–Reference Yang, Lu, Liao and Dang19 A recent meta-analysis further noted a type C configuration in 43.09 %, reporting that the frequencies of each AEA phenotype varied considerably across studies.Reference Szczepanek, Toppich, Ostrowski, Bonczar, Nasser and Dziedzic13 Such heterogeneity likely reflects differences in population characteristics, including regional and ethnic factors, as well as imaging protocols and classification criteria.
Sağlam et al. and Poteet et al. each reported that AEA type C was significantly more common in men than in women and that male patients tended to have a greater lateral lamella height.Reference Sağlam, Deniz, Turmak, Hattapoğlu, Akbudak and Tekinhatun5, Reference Poteet, Cox, Wang, Fitzgerald and Kanaan20 In contrast, other investigations found no significant sex difference in the AEA–skull base distance.Reference Naidu, Sibiya, Aladeyelu and Rennie1, Reference El-Anwar, Khazbak, Eldib and Algazzar3 Gibelli et al. and Randhawa et al. also did not observe sex-based differences in the distribution of AEA types.Reference Gibelli, Cellina, Gibelli, Floridi, Termine and Sforza21, Reference Randhawa, Semwal, Srivastava, Hernot, Azad and Kaintura22 In our analysis, the proportion of men was significantly higher in type C than in type A on unadjusted comparison; however, this association lost significance after adjusting for potential confounders (VFS, VFRAC, HFRAC, SOEC and HLL). Because these covariates reflect paranasal sinus volumes and degrees of pneumatisation, the attenuation of the sex effect after adjustment of the confounders might be explained by the general tendency for men to exhibit greater sinus pneumatisation and larger sinus volumes.Reference Marino, Riley, Wu, Weinstein, Emerson and McCoul23, Reference Cohen, Warman, Fried, Shoffel-Havakuk, Adi and Halperin24
Several studies have linked craniofacial anatomy to AEA position like our study. Higher lateral lamella height or the presence of Keros type III has been associated with an increased likelihood that the AEA courses apart from the skull base in the previous studies.Reference Souza, de Souza, Gregório and Ajzen6, Reference Abdullah, Lim, Mohamad, Husain, Aziz and Snidvongs14, Reference Simmen, Raghavan, Briner, Manestar, Schuknecht and Groscurth16, Reference Poteet, Cox, Wang, Fitzgerald and Kanaan20, Reference Floreani, Nair, Switajewski and Wormald25 In an Indian cohort analysed by Randhawa et al., Keros type III was not observed, yet the proportion of Keros type II rose progressively from AEA type A to B to C (72.6 %, 83.5 % and 94.2 %, respectively).Reference Randhawa, Semwal, Srivastava, Hernot, Azad and Kaintura22 Other authors have reported that a longer anteroposterior extent of the lateral lamella similarly favors a more inferiorly positioned AEA.Reference Yenigun, Goktas, Dogan, Eren and Ozturan26 In line with these observations, our data showed that AEA type is significantly associated with both HLL and Keros classification. Type C exhibited a significantly higher HLL than types A and B. With respect to Keros classification, AEA type C had significantly lower proportions of Keros types I and II and a higher proportion of type III. Notably, Keros type III occurred exclusively in AEA type C in our cohort. These differences in HLL remained significant in multinomial logistic regression. Moreover, correlation analysis demonstrated a significant positive relationship between the DAS and HLL, which persisted after adjustment for age as well as WZ and DNS reflecting head size to account for potential confounding.
Several previous investigations have examined the relationship between the presence of a SOEC and AEA position. Multiple studies have reported that patients with an SOEC have significantly higher odds of belonging to AEA type C than those without an SOEC.Reference Sağlam, Deniz, Turmak, Hattapoğlu, Akbudak and Tekinhatun5, Reference Abdullah, Lim, Mohamad, Husain, Aziz and Snidvongs14, Reference Takeda, Kajiwara, Omura, Otori and Wada27 Another study found that greater expansile development of the SOEC was associated with a significantly increased distance between the AEA and the skull base.Reference Jang, Lachanas, White and Kountakis28 Consistent with these observations, the prevalence of SOEC in our cohort rose progressively from AEA type A to B to C, with a significant difference between types A and C, even though this association weakened and lost statistical significance after adjustment for potential confounders. In contrast to SOEC, the presence of a suprabullar cell has been reported to show no significant association with AEA position.Reference Abdullah, Lim, Mohamad, Husain, Aziz and Snidvongs14 El-Anwar et al. further observed that supraorbital pneumatisation is associated with increases not only in the AEA–skull base distance but also in the AEA–frontal sinus ostium distance and in the angle between the AEA and the lamina papyracea.Reference El-Anwar, Khazbak, Eldib and Algazzar3 Another study, however, has reported no significant relationship between supraorbital pneumatisation and either AEA grade or Keros type.Reference Randhawa, Semwal, Srivastava, Hernot, Azad and Kaintura22 Moreover, one study concluded that the AEA’s location relative to the basal lamella (anterior, within or posterior) is not significantly associated with AEA type.Reference Takeda, Kajiwara, Omura, Otori and Wada27
In this study, VFS, VFRAC and HFRAC differed significantly according to AEA type. In multinomial logistic regression analysis, the differences in VFS and VFRAC between the types B and C remained significant, whereas HFRAC fell below statistical significance. Correlation analyses also showed positive associations between DAS and each of VFS, VFRAC and HFRAC, which persisted after adjustment for the factors related to head size. Although Çomoğlu et al. did not measure frontal sinus volume, they stratified frontal sinus pneumatisation above the orbital roof into three grades and found that more extensive pneumatisation was linked to higher HLL and a greater likelihood of the AEA coursing away from the skull base.Reference Çomoğlu, Şahin, Sönmez and Değer29
In this study, HLL also demonstrated significant positive correlations with VFS, VFRAC and HFRAC. This finding suggests that more extensive pneumatisation of frontal sinus and anterior ethmoid cells tends to accompany a higher HLL. Consistent with this interpretation, Gumus and Yildirim reported that patients with hyperpneumatised frontal sinuses exhibited significantly higher HLL than those without hyperpneumatisation.Reference Gumus and Yildirim30 Moreover, in our dataset, VRS, VFRAC, HFRAC, presence of SOEC, HLL and Keros type were each associated with AEA type and/or DAS. These observations indicate that individuals with more pneumatisation of the anterior ethmoid cells are more likely to have AEA positioned separately from the skull base. Yang et al., in a series of 15 cadaveric specimens, also observed that cases in which the AEA traveled apart from the skull base tended to exhibit more pneumatised ethmoid cells, although formal statistical testing was not performed.Reference Yang, Lu, Liao and Dang19
Developmentally, ethmoid sinuses are known to exist at birth as small cells and generally achieve adult size by approximately 12 years of age.Reference Lee, Fernandez, Mirjalili and Kirkpatrick31 Frontal sinus aeration begins postnatally and may progress into late adolescence or even early adulthood, approximately up to 20–25 years.Reference Lee, Kuhn and Citardi32 This prolonged and individually variable pneumatisation of the ethmoid and frontal sinuses provides a plausible basis for the wide range of adult Keros types and AEA types. Paediatric CT studies have shown that age correlates positively with both HLL and DAS,Reference Chen, Pool, Slonimsky, King, Pradhan and Wilson33, Reference Aksoy34 supporting that the extent of sinus pneumatisation might be associated with AEA position.
This study has limitations. Its retrospective nature introduces potential selection bias, and the sample size was modest. Given the 1-mm slice thickness of the PNS CT scans, slight measurement errors in anatomical lengths and angles are possible. Nonetheless, to the best of our knowledge, we provide a distinctive contribution by quantifying not only lateral lamella height and the presence of a SOEC but also frontal sinus volume and FRAC metrics to examine their relationships with AEA type. Taken together, larger VFS, larger FRAC, the presence of SOEC and a taller lateral lamella were each associated with a greater likelihood that the AEA courses farther from the skull base. These findings support a potential connection between the extent of frontal and ethmoidal pneumatisation and AEA configuration. Clarifying causality, however, will require more studies with standardised imaging and anatomical correlation.
• The anterior ethmoidal artery (AEA) shows variable relationships to the skull base, influencing surgical risk during endoscopic sinus surgery
• Using 3D-reconstructed paranasal sinus CT, this study quantified frontal and ethmoidal pneumatisation parameters to identify anatomical predictors of AEA configuration
• A free-hanging AEA was associated with greater frontal sinus and frontal recess anterior cell volumes, increased lateral lamella height and a higher prevalence of supraorbital ethmoid cells
• The AEA-skull base distance showed significantly positive correlations with lateral lamella height, frontal sinus volume and both the volume and height of frontal recess anterior cells
Conclusion
In this retrospective study, larger frontal sinus volumes, increased FRAC dimensions or height, the presence of SOEC and a taller lateral lamella were each associated with an AEA course positioned apart from the skull base and/or an increased AEA–skull base distance. These observations indicate that the degree of pneumatisation in the frontal sinus and ethmoid cells might play a determining role in anatomical patterns of AEA.
Data availability
The datasets generated and/or analysed during the current study are available in the Zenodo repository [https://zenodo.org/records/18112611].
Contribution of the authors
All authors contributed to the preparation of the manuscript and fulfilled the authorship criteria. Yeon Hee Im: Conceptualization, methodology, writing—original draft preparation, review and editing. Yujeong Hong: Software, visualisation, methodology, data curation. Dong Jun Kim: Software, visualisation, methodology, data curation. Beom Cho Jun: Conceptualization, methodology, writing—review and editing, supervision.
Ethics approval
The Institutional Review Board of the Uijeongbu St. Mary’s Hospital approved this study (approval number UC24RISI0119). The study was performed in accordance with the ethical standards of the 1964 Declaration of Helsinki and its later amendments.
Informed consent
This study is a retrospective analysis based on medical records, and the consent process was exempted.
Competing interests
The authors declare that they have no competing interests.
Funding
This research received no funding.
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