Hostname: page-component-6766d58669-nf276 Total loading time: 0 Render date: 2026-05-18T20:46:28.750Z Has data issue: false hasContentIssue false
  • English
  • Français

Familial cholesteatoma in East Anglia, UK

Published online by Cambridge University Press:  20 May 2008

P Prinsley
P Prinsley*
Affiliation:
Department of Otolaryngology and Head and Neck Surgery, James Paget and Norfolk and Norwich University Hospitals, UK
*
Address for correspondence: Mr P Prinsley, 26 Eaton Rd, Norwich NR4 6PZ, UK. E-mail: prinsley@mac.com
Get access Rights & Permissions [Opens in a new window]

Abstract

Objective:

To report a cluster of families affected by cholesteatoma in the East Anglia region of the UK.

Setting:

Otology service for the population of Norfolk and North Suffolk, East Anglia, UK.

Method:

Prospective and systematic collection of family history data for patients presenting with cholesteatoma over 10 years.

Result:

Several families were identified with affected individuals over several generations.

Conclusion:

There is likely to be a genetic propensity for cholesteatoma in some individuals.

Keywords

CholesteatomaGenetic DiseasesAetiology

Information

Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 123 , Issue 3 , March 2009 , pp. 294 - 297
Copyright
Copyright © JLO (1984) Limited 2008

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

Article purchase

Temporarily unavailable

References

1 Lesinkas, E, Kasinskas, R, Vainutiene, V. Middle ear cholesteatoma; present day concepts of eitiology and pathogenesis. Medicina (Kaunus) 2002;38:1066–71Google Scholar
2 Tos, M. A new pathogenesis for mesotympanic (congenital) cholesteatoma. Laryngoscope 2000;110:1890–7Google Scholar
3 Podoshin, L, Fradis, M, Ben David, Y, Margalit, A, Tamir, A, Epstein, L. Cholesteatoma; an epidemiologic study among members of kibbutzim in Northern Israel. Ann Otol Rhinol Laryngol 1986;95:365–8CrossRefGoogle ScholarPubMed
4 Homoe, P, Rosborg, J. Family cluster of cholesteatoma. J Laryngol Otol 2007;121:65–7Google Scholar
5 Albino, AP, Reed, JA, Bogdany, JK, Sassoon, J, Desloge, RB, Parisier, SC. Expression of p53 protein in human middle ear cholesteatomas: pathogenetic implications. Am J Otol 1998;9:266–72Google Scholar
6 Tokuriki, M, Noda, I, Saito, T, Narita, N, Sunaga, H, Tsuzuki, H et al. Gene expression analysis of human middle ear cholesteatoma using complementary DNA arrays. Laryngoscope 2003;113:808–14Google Scholar
7 Kwon, KH, Kim, SJ, Kim, HJ, Jung, HH. Analysis of gene expression profiles in cholesteatoma using oligonucleotide microarray. Acta Otol 2006;126:691–7Google Scholar