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The anti-inflammatory effects of erythromycin, clarithromycin, azithromycin and roxithromycin on histamine-induced otitis media with effusion in guinea pigs

Published online by Cambridge University Press:  11 June 2018

B Ersoy ,
B Aktan ,
K Kilic ,
M S Sakat  and
S Sipal
B Ersoy
Affiliation:
Department of Otolaryngology, City Hospital, Mersin, Turkey
B Aktan
Affiliation:
Department of Otolaryngology, Faculty of Medicine, Atatürk University, Erzurum, Turkey
K Kilic*
Affiliation:
Department of Otolaryngology, Regional Training and Research Hospital, Erzurum, Turkey
M S Sakat
Affiliation:
Department of Otolaryngology, Faculty of Medicine, Atatürk University, Erzurum, Turkey
S Sipal
Affiliation:
Department of Pathology, Faculty of Medicine, Atatürk University, Erzurum, Turkey
*
Address for correspondence: Dr Korhan Kilic, Department of Otolaryngology, Regional Training and Research Hospital, Erzurum, Turkey E-mail: korhankilic@gmail.com
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Abstract

Background

Otitis media with effusion is a clinical manifestation characterised by inflammation of middle-ear mucosa. This study investigated the therapeutic effect of erythromycin, clarithromycin, azithromycin and roxithromycin on a histamine-induced animal model of otitis media with effusion.

Methods

The animals were divided into five groups, receiving erythromycin, clarithromycin, azithromycin, roxithromycin or saline solution. The guinea pigs in the study groups received erythromycin (40 mg/kg/day), clarithromycin (15 mg/kg/day), azithromycin (10 mg/kg/day) or roxithromycin (10 mg/kg/day) for 3 days by gastric tube. Four hours after the end of the administration, histamine solution was injected into the right middle ear.

Results

The lowest neutrophil density value obtained using stereological techniques was in the azithromycin group (0.86 ± 0.25 × 10−5/μm3), while the highest value was observed in the control group (6.68 ± 3.12 × 10−5/μm3). The anti-inflammatory properties of clarithromycin, azithromycin and roxithromycin were similar to one another, but better than that of erythromycin.

Conclusion

The use of macrolide antibiotics is recommended, as they show antibacterial and anti-inflammatory efficacy in otitis media with effusion.

Keywords

Otitis Media With EffusionErythromycinClarithromycinAzithromycinRoxithromycin

Information

Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 132 , Issue 7 , July 2018 , pp. 579 - 583
Copyright
Copyright © JLO (1984) Limited, 2018 

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Footnotes

Dr K Kilic takes responsibility for the integrity of the content of the paper

References

1Aktan, B, Gundogdu, C, Ucuncu, H, Unal, B, Sütbeyaz, Y, Altas, S. Anti-inflammatory effect of erythromycin on histamine-induced otitis media with effusion in guinea pigs. J Laryngol Otol 2004;118:97–101Google Scholar
2Iino, Y, Sugita, K, Toriyama, M, Kudo, K. Erythromycin therapy for otitis media with effusion in sinobronchial syndrome. Arch Otolaryngol Head Neck Surg 1993;119:648–51Google Scholar
3Culic, O, Erakovic, V, Parnham, MJ. Anti-inflammatory effects of macrolide antibiotics. Eur J Pharmacol 2001;429:209–29Google Scholar
4Cervin, A. The anti-inflammatory effect of erythromycin and its derivatives, with special reference to nasal polyposis and chronic sinusitis. Acta Otolaryngol 2001;121:83–92Google Scholar
5Aktan, B, Taysi, S, Gumustekin, K, Bakan, N, Sutbeyaz, Y. Evaluation of oxidative stress in erythrocytes of guinea pigs with experimental otitis media and effusion. Ann Clin Lab Sci 2003;33:232–6Google Scholar
6Kozan, G, Aktan, B, Sakat, MS, Kurt, S, Öner, F, Kara, A. Effect of systemic clarithromycin and prednisolone on histamine-induced otitis media in guinea pigs. Acta Otolaryngol 2015;135:978–84Google Scholar
7Taysi, S, Ucuncu, H, Elmastas, M, Aktan, B, Emin, Buyukokuroglu M. Effect of melatonin on lipid peroxidation, glutathione and glutathione-dependent enzyme activities in experimental otitis media with effusion in guinea pigs. J Pineal Res 2005;39:283–6Google Scholar
8Nonaka, M, Pawankar, R, Tomiyama, S, Yagi, T. A macrolide antibiotic, roxithromycin, inhibits the growth of nasal polyp fibroblasts. Am J Rhinol 1999;13:267–72Google Scholar
9Tamaoki, J, Kadota, J, Takizawa, H. Clinical implications of the immunomodulatory effect of macrolides. Am J Med 2004;117:5–11Google Scholar
10Yamamoto, K, Arakawa, T, Ueda, N, Yamamoto, S. Transcriptional roles of nuclear factor-κB and nuclear factor-interleukin-6 in the tumor necrosis factor-α dependent induction of cyclooxygenase-2 in MC3T3-E1 cells. J Biol Chem 1995;270:31315–20Google Scholar
11Ianaro, A, Ialenti, A, Maffia, P. Anti-inflammatory activity of macrolide antibiotics. J Pharmacol Exp Ther 2000;292:156–63Google Scholar
12Li, Y, Azuma, A, Takahashi, S. Fourteen-membered ring macrolides inhibit vascular cell adhesion molecule 1 messenger RNA induction and leukocyte migration: role in preventing lung injury and fibrosis in bleomycin-challenged mice. Chest 2002;122:2137–45Google Scholar
13Suzuki, H, Asada, Y, Ikeda, K, Oshima, T, Takasaka, T. Inhibitory effect of erythromycin on interleukin-8 secretion from exudative cells in the nasal discharge of patients with chronic sinusitis. Laryngoscope 1999;109:407–10Google Scholar
14Miyanohara, T, Ushikai, M, Matsune, S. Effects of clarithromycin on cultured human nasal epithelial cells and fibroblast. Laryngoscope 2000;110:126–31Google Scholar
15Labro, MT, el Benna, J, Babin-Chevaye, C. Comparison of the in vitro effect of several macrolides on the oxidative burst of human neutrophils. J Antimicrob Chemother 1989;24:561–72Google Scholar