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Plasmablastic lymphoma of the larynx: report of two cases

Published online by Cambridge University Press:  19 September 2012

K Stephenson ,
S Peer ,
D Govender  and
J J Fagan
K Stephenson*
Affiliation:
Division of Otorhinolaryngology, University of Cape Town, South Africa
S Peer
Affiliation:
Division of Otorhinolaryngology, University of Cape Town, South Africa
D Govender
Affiliation:
Division of Anatomical Pathology, University of Cape Town, South Africa
J J Fagan
Affiliation:
Division of Otorhinolaryngology, University of Cape Town, South Africa
*
Address for correspondence: Dr Kate Stephenson, Division of Otorhinolaryngology, University of Cape Town, H-53 Old Main Building, Groote Schuur Hospital, Observatory, Cape Town 7925, South Africa E-mail: katestephenson@doctors.org.uk
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Abstract

Objective:

To report two cases of laryngeal plasmablastic lymphoma, a rare and relatively recently described form of non-Hodgkin's lymphoma. It has not previously been described in the larynx, nor associated with upper airway obstruction.

Case reports:

We describe the clinicopathological features of two such cases in human immunodeficiency virus positive patients, and we discuss their unusual presentations and diagnostic features.

Conclusion:

When evaluating a laryngeal tumour, plasmablastic lymphoma and other non-Hodgkin's lymphomata should be considered as differential diagnoses, particularly in the setting of a high prevalence of human immunodeficiency virus infection. Biopsy with detailed histopathological and immunohistochemical evaluation is recommended to ensure correct diagnosis and optimal management.

Keywords

LarynxPlasmablastic LymphomaLymphoma, Non-Hodgkin'sLymphoma, B-CellHuman Immunodeficiency Virus

Information

Type
Clinical Records
Information
The Journal of Laryngology & Otology , Volume 127 , Issue 1 , January 2013 , pp. 96 - 99
Copyright
Copyright © JLO (1984) Limited 2012

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References

1 Delecluse, HJ, Anagnostopoulos, I, Dallenbach, F, Hummel, M, Marafioti, T, Schneider, U et al. Plasmablastic lymphomas of the oral cavity: a new entity associated with the human immunodeficiency virus infection. Blood 1997;89:1413–20CrossRefGoogle ScholarPubMed
2 Castillo, JJ, Reagan, JL. Plasmablastic lymphoma: a systematic review. Scientific World Journal 2011;11:687–96CrossRefGoogle ScholarPubMed
3 Castillo, J, Pantanowitz, L, Dezube, B. HIV-associated plasmablastic lymphoma: lessons learned from 112 published cases. Am J Hematology 2008;83:804–9CrossRefGoogle ScholarPubMed
4 Castillo, JJ, Winer, ES, Stachurski, D, Perez, K, Jabbour, M, Milani, C et al. Clinical and pathological differences between human immunodeficiency virus-positive and human immunodeficiency virus-negative patients with plasmablastic lymphoma. Leuk Lymphoma 2010;51:2047–53Google Scholar
5 Carbone, A. AIDS-related non-Hodgkin's lymphomas: from pathology and molecular pathogenesis to treatment. Hum Pathol 2002;33:392–404 Google Scholar
6 Rafaniello Raviele, P, Pruneri, G, Maiorano, E. Plasmablastic lymphoma: a review. Oral Diseases 2009;15:38–45 Google Scholar
7 Bohlius, J, Schmidlin, K, Costagliola, D, Fätkenheuer, G, May, M, Caro-Murillo, AM et al. Incidence and risk factors of HIV-related non-Hodgkin's lymphoma in the era of combination antiretroviral therapy: a European multicohort study. Antivir Ther 2009;14:1065–74Google Scholar
8 Thirlwell, C, Sarker, D, Stebbing, J, Bower, M. Acquired immunodeficiency syndrome-related lymphoma in the era of highly active antiretroviral therapy. Clin Lymphoma 2003;4:86–92 Google Scholar
9 Carbone, A, Cesarman, E, Spina, M, Gloghini, A, Schulz, TF. HIV-associated lymphomas and gamma-herpesviruses. Blood 2009;113:1213–24CrossRefGoogle ScholarPubMed
10 Carbone, A, Gloghini, A. Plasmablastic lymphoma: one or more? Am J Hematol 2008;83:763–4CrossRefGoogle ScholarPubMed
11 Dong, HY, Scadden, DT, de Leval, L, Tang, Z, Isaacson, PG, Harris, NL. Plasmablastic lymphoma in HIV-positive patients: an aggressive Epstein-Barr virus-associated extramedullary plasmacytic neoplasm. Am J Surg Pathol 2005;29:1633–41Google Scholar
12 Castillo, JJ, Winer, ES, Stachurski, D, Perez, K, Jabbour, M, Milani, C et al. Prognostic factors in chemotherapy-treated patients with HIV-associated plasmablastic lymphoma. Oncologist 2010;15:293–9CrossRefGoogle ScholarPubMed
13 Guan, B, Zhang, X, Ma, H, Zhou, H, Zhou, X. A meta-analysis of highly active anti-retroviral therapy for treatment of plasmablastic lymphoma. Ann Saudi Med 2010;30:123–8Google Scholar