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Use of acellular dermal matrices in laryngotracheal and pharyngeal reconstruction: systematic review

Published online by Cambridge University Press:  15 May 2017

A Hui ,
P Hong  and
M Bezuhly
A Hui
Affiliation:
Faculty of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada
P Hong
Affiliation:
Division of Otolaryngology, IWK Health Centre, Dalhousie University, Halifax, Nova Scotia, Canada
M Bezuhly*
Affiliation:
Division of Plastic and Reconstructive Surgery, IWK Health Centre, Dalhousie University, Halifax, Nova Scotia, Canada
*
Address for correspondence: Dr Michael Bezuhly, Division of Plastic and Reconstructive Surgery, IWK Health Centre, Dalhousie University, 5850/5980 University Avenue, PO Box 9700, Halifax, Nova Scotia B3K 6R8, Canada Fax: +1 902 470 7939 E-mail: mbezuhly@dal.ca
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Abstract

Background:

Acellular dermal matrices are increasingly used in laryngotracheal and pharyngeal reconstruction, but specific indications and the type of acellular dermal matrix used vary. The authors systematically reviewed outcomes relating to acellular dermal matrix use in head and neck reconstruction.

Methods:

Electronic databases were searched through 1 May 2016 for literature on acellular dermal matrix use in laryngotracheal and pharyngeal reconstruction. Studies were appraised for surgical indications, outcomes and study design.

Results:

Eleven publications with 170 cases were included. Eight articles reported on acellular dermal matrix use in oncological reconstruction. Most studies were case series; no high-level evidence studies were identified. Graft extrusion was more common in non-oncological applications. In general, post-oncological reconstruction with an acellular dermal matrix demonstrated complication rates similar to those reported without an acellular dermal matrix.

Conclusion:

Evidence in support of acellular dermal matrix use in head and neck reconstruction is generally poor. Prospective comparative studies are required to define the indications, safety and effectiveness of acellular dermal matrices in laryngotracheal and pharyngeal reconstruction.

Keywords

Acellular Dermal MatrixLaryngectomyPharyngectomyHypopharyngeal CancerReconstructionRadiotherapyTonsillectomyVelopharyngeal Insufficiency

Information

Type
Review Articles
Information
The Journal of Laryngology & Otology , Volume 131 , Issue 7 , July 2017 , pp. 585 - 592
Copyright
Copyright © JLO (1984) Limited 2017 

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