KEY CLINICAL QUESTIONS

1.

What are donation clinical triggers?

Clinical triggers for organ donation define a potential organ donor and help remind health care teams to initiate referral to their organ donation organization in a timely manner. They have been shown to increase donation rates and allow earlier recognition and mobilization of donation resources.^{Reference Wojda, Stawicki and Yandle1}

Patients who meet the following clinical triggers should be considered a potential organ donor and be referred to the organ donation organization^{Reference Zavalkoff, Shemie and Grimshaw2}:

1. 1. Ventilated (invasive [intubated/tracheotomy] or noninvasive [bilevel positive airway pressure/continuous positive airway pressure] ventilation) OR circulatory support (medical [vasopressors/inotropes] or mechanical [ventricular assist devices]).

   AND

2. 2. Condition with a grave prognosis in which

   1. a. death is imminent

      OR

   2. b. A decision to withdraw life sustaining measures has been made (but not yet acted upon).

2.

What is the role of the emergency department in identifying and referring a patient who meets these clinical triggers?

In Canada, the gap between availability and need of organs for transplantation remains large. Although there has been a 40% increase in deceased donation rates over the past decade, Canada still underperforms in comparison to estimated donor potential and other countries.³ Failure to identify and refer a potential donor has life-threatening consequences for patients on the transplant waiting list, as one donor on average provides two to four transplants. It also denies donor families the opportunity to find some meaning in an otherwise devasting event. Emergency health care providers are front-line clinicians and often the initial point of contact with potential donors and their families. It is essential that they have the knowledge and resources to identify and refer potential donors in a timely manner. Failure to do so may compromise the entire donation process.

3.

Does this patient meet the clinical triggers and what is the role of the organ donation organization at this point?

Opportunity for organ donation should be considered an integral part of high-quality, end of life care. This involves referral to an organ donation organization before enacting any comfort measures which may compromise the opportunity to donate (e.g., extubation).

Although initial examination and imaging are suggestive of a poor outcome, early neuroprognostication may be misleading. At this point, the patient is still appropriately receiving active medical care in the emergency department. Any end of life assessments or discussions should only be made after a suitable period of time has allowed for multiple assessments of the patient and prognosis by experts in the patient's medical condition.^{Reference Callaway, Donnino and Fink4}

Currently, the patient does not meet all clinical triggers, as her prognosis is not yet clear. As such, referral to the organ donation organization is not required. However, early notification/consultation of the organ donation organization may still be appropriate and beneficial. For example, preliminary screening may determine the patient is medically unsuitable and would prevent offering the opportunity to the family when the opportunity does not exist, determine if the patient has registered their intent to donate, or allow travel time for a donation coordinator to offer on-site support to the family and team.^{Reference Zavalkoff, Shemie and Grimshaw2}

4.

What are key considerations for medical support while the patient is still in the emergency department?

At this stage, the goal is physiological stability and recovery of the patient. The goal does not yet include preserving the opportunity to donate. Consideration should be given to transferring the patient to another location (e.g., intensive care unit) or institution (e.g., advanced neurocritical care center), as required, to ensure the above supports are expertly administered. While waiting for transfer, neuroprotective measures should be maintained to prevent secondary neurological injury.

If the patient is assessed by experts in the emergency department and the injury is deemed to be nonsurvivable, or the patient has progressed to neurological death, normal physiological parameters should still be maintained until the patient is able to be assessed for the possibility of donation. Without maintenance of these parameters, the patient may become unstable and a donation opportunity lost. In this instance, a transfer solely for the purpose of donation may be appropriate but must be clearly communicated to the family before transfer.

5.

What are other key considerations for the patient and family while in the emergency department?

Social, psychological, and spiritual support of the patient and family are key components of high-quality health care. For families, this process starts on arrival to the hospital. Proactive interventions, such as social work involvement, family rooms, and spiritual care support, have shown some success in mitigating psychological distress and its sequelae.

6.

In what setting should the opportunity for donation be offered to the family?

These difficult conversations should be led by donation experts and only be held after a family are accepting of a diagnosis of neurological death or a decision has been made to withdrawal life sustaining measures. It is preferable for discussions about donation to be held in a separate meeting from the end of life discussions.^{Reference Shemie, Robertson and Beitel5}

In Canada, however, regional system organization and practice may preclude donation experts from leading these discussions. If this is the case at your institution, the case should be discussed with your local organ donation organization before any organ donation conversations with family. This will ensure the patient is medically suitable before offering the opportunity to family and will also provide support and education to the health care team.^{Reference Shemie, Robertson and Beitel5}

CASE RESOLUTION

The patient was supported in the emergency department until transfer was arranged to a neurosurgical intensive care unit. Over the next 72 hours, the patient was assessed and deemed to have a nonsurvivable injury. Withdrawal of life sustaining measures was recommended. This was communicated to the family and support was provided by spiritual care and social work. The organ donation organization was formally consulted, and collaboratively the team offered the family the opportunity for organ donation. The patient progressed to neurological death and successfully donated four organs.