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Association between Systemic Immune-Inflammation Index (SII) and secondary haemorrhage risk after tonsillectomy

Published online by Cambridge University Press:  29 July 2025

Murat Gümüşsoy Open the ORCID record for Murat Gümüşsoy [Opens in a new window] ,
Özlem Yagız Agayarov  and
Ibrahim Çukurova
Murat Gümüşsoy*
Affiliation:
Department of Otolaryngology Head and Neck Surgery, University of Health Sciences, Izmir Tepecik Training and Research Hospital, Izmir, Turkey
Özlem Yagız Agayarov
Affiliation:
Department of Otolaryngology Head and Neck Surgery, University of Health Sciences, Izmir Tepecik Training and Research Hospital, Izmir, Turkey
Ibrahim Çukurova
Affiliation:
Department of Otolaryngology Head and Neck Surgery, University of Health Sciences, Izmir Tepecik Training and Research Hospital, Izmir, Turkey
*
Corresponding author: Murat Gümüşsoy; Email: mgumussoy@hotmail.com
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Abstract

Objectives

This study evaluates the relationship between Systemic Immune-Inflammation Index and secondary tonsillar haemorrhage after tonsillectomy.

Methods

Sixty pediatric patients with secondary haemorrhage and 60 without bleeding were grouped for comparative analysis. Laboratory parameters and Systemic Immune-Inflammation Index values were collected preoperatively, on the bleeding day and on the control day, then compared.

Results

Secondary haemorrhage occurred in 60 patients (3.11 per cent), with a mean age of 8.85 ± 3.07 years. Bleeding occurred at 8.63 ± 2.32 days post-operatively (range: 72 hours–21 days). Tonsillectomy day: Neutrophil count and Systemic Immune-Inflammation Index were significantly higher in the haemorrhage group (p < 0.001). Haemorrhage vs. tonsillectomy day (haemorrhage group): Platelet, neutrophil and Systemic Immune-Inflammation Index increased, while lymphocytes decreased (p < 0.001). Haemorrhage vs. control day: Neutrophil count and Systemic Immune-Inflammation Index remained significantly higher (p < 0.001).

Conclusion

Systemic Immune-Inflammation Index, a novel inflammatory marker, may help predict post-tonsillectomy haemorrhage risk.

Keywords

lymphocyteneutrophilplateletpost-operative haemorrhagetonsillectomy

Information

Type
Main Article
Information
The Journal of Laryngology & Otology , Volume 139 , Issue 10 , October 2025 , pp. 971 - 975
Copyright
© The Author(s), 2025. Published by Cambridge University Press on behalf of J.L.O. (1984) LIMITED.

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Footnotes

Murat Gümüşsoy takes responsibility for the integrity of the content of the paper

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